V LegryD CottelJ FerrièresAssociation between liver X receptor α gene polymorphisms and risk of metabolic syndrome in French populationsInt J Obes (Lond)324214282008

BM StensonM RydénN VenteclefLiver X receptor (LXR) regulates human adipocyte lipolysisJ Biol Chem286370379201110.1074/jbc.M110.17949921030586

TJ BerrodinQ ShenEM QuinetIdentification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activityMol Pharmacol78104610582010

M Korach-AndréA ArcherRP BarrosBoth liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activityProc Natl Acad Sci USA108403408201121173252

K MotoshimaT Noguchi-YachideK SugitaSeparation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonistsBioorg Med Chem17500150142009

T YasudaD GrillotJT BillheimerTissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivoArterioscler Thromb Vasc Biol30781786201010.1161/ATVBAHA.109.19569320110577

Q ShenY BaiKC ChangLiver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytesJ Biol Chem2861455414563201110.1074/jbc.M110.16570421349840

R LallS KuruvillaK PrüferLiver X receptor beta with mutations in the activation function-2 region is excluded from the nucleolusCell Biol Int33447452200910.1016/j.cellbi.2009.01.01519356704

M NoshiroE UsuiT KawamotoMultiple mechanisms regulate circadian expression of the gene for cholesterol 7α-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesisJ Biol Rhythms22299311200717660447

AS HenkelKA AndersonAM DeweyA chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ miceJ Lipid Res52289298201110.1194/jlr.M01278121097822

M SatoK SatoM FuruseChange in hepatic and plasma bile acid contents and its regulatory gene expression in the chicken embryoComp Biochem Physiol B Biochem Mol Biol150344347200810.1016/j.cbpb.2008.04.00318499494

CR Wooton-KeeDJ CoyAT AthippozhyMechanisms for increased expression of cholesterol 7α-hydroxylase (Cyp7a1) in lactating ratsHepatology512772852010

M Hozoji-InadaY MunehiraK NagaoLXRβ directly interacts with ABCA1 to promote HDL formation during acute cholesterol accumulationJ Biol Chem28620117201242011

JJ DonkinS StukasV Hirsch-ReinshagenATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 miceJ Biol Chem2853414434154201010.1074/jbc.M110.108100

A TsezouD IliopoulosKN MalizosImpaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytesJ Orthop Res2810331039201020108316

FD GenvigirAC RodriguesA CerdaEffects of lipid-lowering drugs on reverse cholesterol transport gene expressions in peripheral blood mononuclear and HepG2 cellsPharmacogenomics1112351246201010.2217/pgs.10.9320860464

A AkramJ SchmeidlerP KatselIncreased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?Mol Neurodegener5362010

EA HuwaitKR GreenowNN SinghA novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expressionCell Signal23542549201110.1016/j.cellsig.2010.11.00221070853

JP MauldinMH NagelinAJ WojcikReduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitusCirculation11727852792200810.1161/CIRCULATIONAHA.107.741314

CJ DelvecchioP BilanP NairLXR-induced reverse cholesterol transport in human airway smooth muscle is mediated exclusively by ABCA1Am J Physiol Lung Cell Mol Physiol295L949L957200810.1152/ajplung.90394.200818820007

H WiersmaN NijstadJF de BoerLack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol dietAtherosclerosis206141147200910.1016/j.atherosclerosis.2009.02.02219339012

J EckerG LiebischW PatschThe conjugated linoleic acid isomer trans-9,trans-11 is a dietary occurring agonist of liver X receptor αBiochem Biophys Res Commun388660666200919682978

DD BojanicPT TarrGD GaleDifferential expression and function of ABCG1 and ABCG4 during development and agingJ Lipid Res51169181201010.1194/M900250-JLR20019633360

N WangL Yvan-CharvetD LütjohannATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brainFASEB J2210731082200810.1096/fj.07-9944com18039927

EM Van StratenNC HuijkmanJF BallerPharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolismAm J Physiol Endocrinol Metab295E1341E1348200818840761

H KusuharaY SugiyamaATP-binding cassette, subfamily G (ABCG family)Pflugers Arch453735744200710.1007/s00424-006-0134-x16983557

NP HessvikMV BoekschotenMA BaltzersenLXRβ is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol effluxAm J Physiol Endocrinol Metab298E602E6132010

JM TaylorF BorthwickC BartholomewOverexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AICardiovasc Res86526534201010.1093/cvr/cvq015

S ZhongAL MagnoloM SundaramNonsynonymous mutations within APOB in human familial hypobetalipoproteinemia: evidence for feedback inhibition of lipogenesis and postendoplasmic reticulum degradation of apolipoprotein BJ Biol Chem28564536464201010.1074/jbc.M109.060467

S HonzumiA ShimaA HiroshimaLXRα regulates human CETP expression in vitro and in transgenic miceAtherosclerosis2121391452010

F BriandM TréguierA AndréLiver X receptor activation promotes macrophage-to-feces reverse cholesterol transport in a dyslipidemic hamster modelJ Lipid Res51763770201010.1194/jlr.M00155219965597

D LakomyC RébéAL SbernaLiver X receptor-mediated induction of cholesteryl ester transfer protein expression is selectively impaired in inflammatory macrophagesArterioscler Thromb Vasc Biol2919231929200910.1161/ATVBAHA.109.193201

M Korach-AndréA ArcherC GabbiLiver-X Receptors regulate de novo lipogenesis in a tissue specific manner in C57Bl/6 female miceAm J Physiol Endocrinol Metab301E210E222201121521718

I HongHS RhoDH KimActivation of LXRα induces lipogenesis in HaCaT cellsArch Pharm Res33144314492010

HY KayWD KimSJ HwangNrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase bindingAntioxid Redox Signal15213521462011

K SatoT KamadaRegulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptorsComp Biochem Physiol A Mol Integr Physiol158201206201110.1016/j.cbpa.2010.10.02821056113

MP MorrowA GrantZ MujawarStimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1Mol Pharmacol78215225201010.1124/mol.110.06502920479131

D TöröcsikM BaráthS BenkoActivation of liver X receptor sensitizes human dendritic cells to inflammatory stimuliJ Immunol18454565465201020410489

H KorfS Vander BekenM RomanoLiver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in miceJ Clin Invest11916261637200910.1172/JCI3528819436111

C FontaineE RigamontiA NoharaLiver X receptor activation potentiates the lipopolysaccharide response in human macrophagesCirc Res1014049200710.1161/CIRCRESAHA.106.13581417540978

W HuangS GhislettiK SaijoCoronin 2A mediates actin-dependent de-repression of inflammatory response genesNature470414418201110.1038/nature0970321331046

S ChenR SorrentinoK ShimadaChlamydia pneumoniae-induced foam cell formation requires MyD88-dependent and independent signaling and is reciprocally modulated by liver X receptor activationJ Immunol18171867193200810.4049/jimmunol.181.10.7186

D TerwelKR SteffensenPB VergheseCritical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosisJ Neurosci3170497059201121562267