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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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May 2012 Volume 5 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China

  • Authors:
    • Yu Han
    • Zhen-Yu Jiang
    • Li-Xin Jiao
    • Cheng Yao
    • Qian-Fei Lin
    • Ning Ma
    • Rui-Qing Ju
    • Fan Yang
    • Jiang-Hong Yu
    • Lin Chen

  • View Affiliations / Copyright

    Affiliations: Jilin Blood Center, Changchun, Jilin 130033, P.R. China, First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China
  • Pages: 1347-1351
    |
    Published online on: February 20, 2012
       https://doi.org/10.3892/mmr.2012.800
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Abstract

Human leukocyte antigen (HLA) class II molecule is an integral component of the immune response on which the majority of host genetic studies have concentrated. Many different HLA-II alleles have been demonstrated to play roles in HBV infection. PCR-SSOP methods were applied to determine the HLA-DRB1 genotypes of 769 unrelated healthy individuals from Han Chinese of Northeast China. The frequencies of HLA-DRB1*09 in hepatitis B virus (HBV)-infected subjects were higher compared to those in the control group. Frequencies of HLA-DRB1*04 and *13 in the HBV-infected group were significantly lower compared to those in the healthy control group. Frequencies of HLA-DRB1*12 in the cirrhosis and liver cancer groups were significantly higher than those in the chronic hepatitis B (CHB) patients. The frequency of LA-DRB1*03 in the CHB patient group was significantly higher compared to that in the asymptomatic hepatitis B carrier patients. The above results suggest that the host HLA-II gene is an important factor in the determination of the outcome of HBV infection.

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Copy and paste a formatted citation
Spandidos Publications style
Han Y, Jiang Z, Jiao L, Yao C, Lin Q, Ma N, Ju R, Yang F, Yu J, Chen L, Chen L, et al: Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China. Mol Med Rep 5: 1347-1351, 2012.
APA
Han, Y., Jiang, Z., Jiao, L., Yao, C., Lin, Q., Ma, N. ... Chen, L. (2012). Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China. Molecular Medicine Reports, 5, 1347-1351. https://doi.org/10.3892/mmr.2012.800
MLA
Han, Y., Jiang, Z., Jiao, L., Yao, C., Lin, Q., Ma, N., Ju, R., Yang, F., Yu, J., Chen, L."Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China". Molecular Medicine Reports 5.5 (2012): 1347-1351.
Chicago
Han, Y., Jiang, Z., Jiao, L., Yao, C., Lin, Q., Ma, N., Ju, R., Yang, F., Yu, J., Chen, L."Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China". Molecular Medicine Reports 5, no. 5 (2012): 1347-1351. https://doi.org/10.3892/mmr.2012.800
Copy and paste a formatted citation
x
Spandidos Publications style
Han Y, Jiang Z, Jiao L, Yao C, Lin Q, Ma N, Ju R, Yang F, Yu J, Chen L, Chen L, et al: Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China. Mol Med Rep 5: 1347-1351, 2012.
APA
Han, Y., Jiang, Z., Jiao, L., Yao, C., Lin, Q., Ma, N. ... Chen, L. (2012). Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China. Molecular Medicine Reports, 5, 1347-1351. https://doi.org/10.3892/mmr.2012.800
MLA
Han, Y., Jiang, Z., Jiao, L., Yao, C., Lin, Q., Ma, N., Ju, R., Yang, F., Yu, J., Chen, L."Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China". Molecular Medicine Reports 5.5 (2012): 1347-1351.
Chicago
Han, Y., Jiang, Z., Jiao, L., Yao, C., Lin, Q., Ma, N., Ju, R., Yang, F., Yu, J., Chen, L."Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B virus infection in the Han Chinese of Northeast China". Molecular Medicine Reports 5, no. 5 (2012): 1347-1351. https://doi.org/10.3892/mmr.2012.800
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