Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation

  • Authors:
    • Chang Deng
    • Ran Tao
    • Shun-Zhi Yu
    • Hua Jin
  • View Affiliations

  • Published online on: April 27, 2012     https://doi.org/10.3892/mmr.2012.894
  • Pages: 215-219
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Abstract

Endoplasmic reticulum (ER) stress plays a key role in the development of neurodegenerative diseases, including Parkinson's disease (PD). Sulforaphane (SF) is a natural drug derived from isothiocyanate found in cruciferous vegetables. Although there are reports indicating that SF is a potential candidate for PD treatment, there have been no reports on the effects of SF on ER stress in PD. In this study, we investigated the cytoprotective effects of SF on 6-hydroxydopamine (6-OHDA)-induced ER stress in rat PC12 cells. Pre-treatment with SF elicited cytoprotection against 6-OHDA-induced cytotoxicity. Consistent with its cytoprotective action, SF significantly inhibited subsequent ER stress, including the expression of Bip and the C/EBP homologous protein. We also found that transfection with NF-E2-related factor-2 (Nrf2) siRNA reversed the inhibitory effects of SF on 6-OHDA-induced ER stress responses. In conclusion, our results show that SF can prevent ER stress response induced by 6-OHDA through the activation of Nrf2. SF may be a therapeutic candidate for the treatment of ER stress-associated neural diseases, including PD.

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July 2012
Volume 6 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Deng C, Tao R, Yu S and Jin H: Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation. Mol Med Rep 6: 215-219, 2012.
APA
Deng, C., Tao, R., Yu, S., & Jin, H. (2012). Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation. Molecular Medicine Reports, 6, 215-219. https://doi.org/10.3892/mmr.2012.894
MLA
Deng, C., Tao, R., Yu, S., Jin, H."Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation". Molecular Medicine Reports 6.1 (2012): 215-219.
Chicago
Deng, C., Tao, R., Yu, S., Jin, H."Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation". Molecular Medicine Reports 6, no. 1 (2012): 215-219. https://doi.org/10.3892/mmr.2012.894