Expression and significance of PTEN and miR-92 in hepatocellular carcinoma

  • Authors:
    • Bin Zhao
    • Yueting Zhu
    • Kai Cui
    • Jie Gao
    • Fachang Yu
    • Liang Chen
    • Sheng Li
  • View Affiliations

  • Published online on: March 28, 2013     https://doi.org/10.3892/mmr.2013.1406
  • Pages: 1413-1416
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Abstract

The aim of this study was to investigate the correlation between the expression levels of the tumor suppressor gene phosphatase and tensin homolog (PTEN) and the microRNA (miRNA) miR-92 in hepatocellular carcinoma (HCC) and paracancerous tissue. Immunohistochemistry [streptavidin-peroxidase (SP)] and quantitative reverse transcriptase-polymerase chain reaction (qRT‑PCR) were used to detect the expression of PTEN and miR-92 in 15 cases of HCC and the corresponding paracancerous tissues. The correlation between PTEN and miR-92 was analyzed. The expression of PTEN mRNA and protein was significantly lower in HCC compared with that in paracancerous tissues (P<0.05). miR-92 showed the opposite expression pattern (P<0.05). Additionally, the mRNA levels of PTEN and miR-92 showed a significantly negative correlation with each other (r=-0.858, P<0.05). In conclusion, PTEN and miR-92 have different roles in the development of HCC. The combined detection of PTEN and miR-92 may provide critical clinical evidence for the early diagnosis and prognosis of HCC.
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May 2013
Volume 7 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhao B, Zhu Y, Cui K, Gao J, Yu F, Chen L and Li S: Expression and significance of PTEN and miR-92 in hepatocellular carcinoma. Mol Med Rep 7: 1413-1416, 2013.
APA
Zhao, B., Zhu, Y., Cui, K., Gao, J., Yu, F., Chen, L., & Li, S. (2013). Expression and significance of PTEN and miR-92 in hepatocellular carcinoma. Molecular Medicine Reports, 7, 1413-1416. https://doi.org/10.3892/mmr.2013.1406
MLA
Zhao, B., Zhu, Y., Cui, K., Gao, J., Yu, F., Chen, L., Li, S."Expression and significance of PTEN and miR-92 in hepatocellular carcinoma". Molecular Medicine Reports 7.5 (2013): 1413-1416.
Chicago
Zhao, B., Zhu, Y., Cui, K., Gao, J., Yu, F., Chen, L., Li, S."Expression and significance of PTEN and miR-92 in hepatocellular carcinoma". Molecular Medicine Reports 7, no. 5 (2013): 1413-1416. https://doi.org/10.3892/mmr.2013.1406