Correlation between antibodies and histology in celiac disease: Incidence of celiac disease is higher than expected in the pediatric population

Makovicky,Peter; Rimarova,Kvetoslava; Boor,Andrej; Makovicky,Pavol; Vodicka,Pavel; Samasca,Gabriel; Kruzliak,Peter

doi:10.3892/mmr.2013.1627

Correlation between antibodies and histology in celiac disease: Incidence of celiac disease is higher than expected in the pediatric population

Authors:
- Peter Makovicky
- Kvetoslava Rimarova
- Andrej Boor
- Pavol Makovicky
- Pavel Vodicka
- Gabriel Samasca
- Peter Kruzliak
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Affiliations: Department of Veterinary Sciences, Czech University of Life Sciences in Prague, CZ-165 21 Prague, Czech Republic, Institution of Public Health, Pavol Jozef Safarik University in Košice, SK-040 11 Košice, Slovak Republic, Institution of Pathology, Pavol Jozef Safarik University in Košice, SK-040 11 Košice, Slovak Republic, Department of Biology, Selye Janos University, SK-945 01 Komarno, Slovak Republic, Department of the Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, CZ-142 20 Prague, Czech Republic, Institution of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, RO-400177 Cluj‑Napoca, Romania, Department of Pediatric Gastroenterology, Hospital in Zvolen, SK-960 01 Zvolen, Slovak Republic
Published online on: August 13, 2013 https://doi.org/10.3892/mmr.2013.1627
Pages: 1079-1083

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Abstract

The present study aims to report on the correlation between the degree of negativity of anti-endomysial antibodies and anti-tissue transglutaminase antibodies in the IgA and IgG classes with regard to histological grade, in 44 newly diagnosed children with celiac disease (CD). Samples with negative antibodies, but a positive histology from a 5-year program searching for CD in the pediatric population were collected. A total of 4247 biopsy samples were used in this study. We documented that certain pediatric patients are seronegative, while the disease is active and the incidence of CD is higher than expected in the pediatric population. This is an important finding, which demonstrates the lack of association between autoantibodies and lesions, and justifies the use of biopsies for an accurate CD diagnosis and the importance of revising the diagnostic criteria in a clinical, endoscopic and serological context. We recommend a more active search for incidences of the disease in the pediatric population. Serological markers are not the main method for the diagnosis of CD as they are considered to only have a supporting role clinically. Biopsies of the small intestine are always necessary for the diagnosis of CD in these patients.

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