CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived suppressor cells

  • Authors:
    • Jie Chen
    • Chengyu Deng
    • Qingmin Shi
    • Jun Jiang
    • Yongbo Zhang
    • Wei Shan
    • Weimin Sun
  • View Affiliations

  • Published online on: August 27, 2013     https://doi.org/10.3892/mmr.2013.1655
  • Pages: 1149-1154
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Abstract

Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) perform a number of functions in different immunological settings. In standard in vitro experiments, DCs are produced from mouse bone marrow (BM) cells in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4. Our previous study demonstrated that BM precursor cells could differentiate into MDSCs when co-cultured with poly (I:C). In the present study, BM precursor cells cultured in GM-CSF and IL-4 were treated with CpG oligodeoxynucleotide (CpG ODN). We observed that Gr1+CD11b+ cells exhibiting MDSC functions accumulated in the co-culture system. A similar phenomenon was also observed in Listeria monocytogenes-infected mice. In conclusion, we demonstrated that prolonged CpG ODN stimulation could inhibit the development of DCs and induce the differentiation of BM precursor cells into MDSCs.
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October 2013
Volume 8 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen J, Deng C, Shi Q, Jiang J, Zhang Y, Shan W and Sun W: CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived suppressor cells. Mol Med Rep 8: 1149-1154, 2013.
APA
Chen, J., Deng, C., Shi, Q., Jiang, J., Zhang, Y., Shan, W., & Sun, W. (2013). CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived suppressor cells. Molecular Medicine Reports, 8, 1149-1154. https://doi.org/10.3892/mmr.2013.1655
MLA
Chen, J., Deng, C., Shi, Q., Jiang, J., Zhang, Y., Shan, W., Sun, W."CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived suppressor cells". Molecular Medicine Reports 8.4 (2013): 1149-1154.
Chicago
Chen, J., Deng, C., Shi, Q., Jiang, J., Zhang, Y., Shan, W., Sun, W."CpG oligodeoxynucleotide induces bone marrow precursor cells into myeloid-derived suppressor cells". Molecular Medicine Reports 8, no. 4 (2013): 1149-1154. https://doi.org/10.3892/mmr.2013.1655