Infantile hemangioma of the liver in an adult: A case report and review of the literature

Sumi,Akiko; Akiba,Jun; Nagata,Shuji; Tonan,Tatsuyuki; Nomura,Yoriko; Ogata,Toshiro; Uchida,Masafumi; Nakashima,Osamu; Kage,Masayoshi; Yano,Hirohisa

doi:10.3892/mmr.2013.1749

Infantile hemangioma of the liver in an adult: A case report and review of the literature

Authors:
- Akiko Sumi
- Jun Akiba
- Shuji Nagata
- Tatsuyuki Tonan
- Yoriko Nomura
- Toshiro Ogata
- Masafumi Uchida
- Osamu Nakashima
- Masayoshi Kage
- Hirohisa Yano
View Affiliations

Affiliations: Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Department of Radiology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Department of Radiology, Kurume University Medical Center, Kurume, Fukuoka 839-0863, Japan, Department of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan
Published online on: October 22, 2013 https://doi.org/10.3892/mmr.2013.1749
Pages: 23-27

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Infantile hemangioma (IH), a representative vascular liver tumor, usually occurs in infancy or early childhood but rarely in adults. In this study, we describe a case of IH in a 47-year-old female and we also review the literature. A plain computed tomography (CT) image revealed five hypoattenuating masses in the liver. A dynamic study revealed the masses appeared to be well-enhanced in the arterial phase, and were considered to be high-flow hemangiomas. The tumors appeared as hypointense tumors on the T1-weighted images and as hyperintensities on fat-suppression T2-weighted images. Following the administration of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA), tumors appeared to be well-enhanced in the arterial phase. In the portal phase, tumors demonstrated isointensity compared with the surrounding liver parenchyma, and hypointensity in the equilibrium and hepatobiliary phases. The apparent diffusion coefficient (ADC) values ranged from 2.0 to 2.4x10-3 mm2/sec. Microscopically, the tumors were composed of numerous capillary-like small vessels lined with plump endothelial cells, arranged in a single layer without mitoses, and small bile ducts were trapped and scattered within the tumor. These findings were considered to be characteristic of IH. To the best of our knowledge, this case is the third report on IH in adults.

View Figures

View References

1	Selby DM, Stocker JT, Waclawiw MA, Hitchcock CL and Ishak KG: Infantile hemangioendothelioma of the liver. Hepatology. 20:39–45. 1994.PubMed/NCBI
2	Woltering MC, Robben S and Egeler RM: Hepatic hemangioendothelioma of infancy: treatment with interferon alpha. J Pediatr Gastroenterol Nutr. 24:348–351. 1997. View Article : Google Scholar : PubMed/NCBI
3	Diment J, Yurim O and Pappo O: Infantile hemangioendothelioma of the liver in an adult. Arch Pathol Lab Med. 125:931–932. 2001.PubMed/NCBI
4	Bosman FT, Carineiro F, Hruban RH and Theise ND: WHO Classification of Tumors of the Digestive System. 4th edition. World Health Organisation; Geneva: pp. 242–243. 2010
5	Burt AD, Portmann BC and Ferrell LD: MacSween’s Pathology of the liver. 6th edition. Elsevier Limited; Philadelphia, PA: pp. 796–797. 2012
6	Kuntz E and Kuntz HD: Hepatology Textbook and Atlas. Third edition. Springer; Medizin Verlag, Heidelberg: pp. 781–782. 2008
7	Kassarjian A, Zurakowski D, Dubois J, Paltiel HJ, Fishman SJ and Burrows PE: Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR Am J Roentgenol. 182:785–795. 2004. View Article : Google Scholar : PubMed/NCBI
8	Mortele KJ, Mergo PJ, Urrutia M and Ros PR: Dynamic gadolinium-enhanced MR findings in infantile hepatic hemangioendothelioma. J Comput Assist Tomogr. 22:714–717. 1998. View Article : Google Scholar : PubMed/NCBI
9	Keslar PJ, Buck JL and Selby DM: From the archives of the AFIP. Infantile hemangioendothelioma of the liver revisited. Radiographics. 13:657–670. 1993. View Article : Google Scholar : PubMed/NCBI
10	Feng ST, Chan T, Ching AS, Sun CH, Guo HY, Fan M, Meng QF and Li ZP: CT and MR imaging characteristics of infantile hepatic hemangioendothelioma. Eur J Radiol. 76:e24–e29. 2010. View Article : Google Scholar : PubMed/NCBI
11	Mortelé KJ, Vanzieleghem B, Mortelé B, Benoit Y and Ros PR: Solitary hepatic infantile hemangioendothelioma: dynamic gadolinium-enhanced MR imaging findings. Eur Radiol. 12:862–865. 2002.PubMed/NCBI
12	Tamada T, Ito K, Yamamoto A, Sone T, Kanki A, Tanaka F and Higashi H: Hepatic hemangiomas: evaluation of enhancement patterns at dynamic MRI with gadoxetate disodium. AJR Am J Roentgenol. 196:824–830. 2011. View Article : Google Scholar : PubMed/NCBI
13	Vossen JA, Buijs M, Liapi E, Eng J, Bluemke DA and Kamel IR: Receiver operating characteristic analysis of diffusion-weighted magnetic resonance imaging in differentiating hepatic hemangioma from other hypervascular liver lesions. J Comput Assist Tomogr. 32:750–756. 2008. View Article : Google Scholar
14	Taouli B, Vilgrain V, Dumont E, Daire JL, Fan B and Menu Y: Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology. 226:71–78. 2003. View Article : Google Scholar
15	Ishak KG, Goodman ZD and Stocker TJ: Atlas of Tumor Pathology. Tumors of the Liver and Intrahepatic Bile Ducts. Armed Forces Institute of Pathology; Washington, D.C: 2001
16	Dachman AH, Lichtenstein JE, Friedman AC and Hartman DS: Infantile hemangioendothelioma of the liver: a radiologicpathologic-clinical correlation. AJR Am J Roentgenol. 140:1091–1096. 1983. View Article : Google Scholar : PubMed/NCBI
17	Okuda K and Ishak KG: Neoplasms of the Liver. Springer-Verlag; Tokyo: 1987, View Article : Google Scholar
18	Kanel GC and Korula J: Atlas of Liver Pathology. 3rd edition. Elsevier Saunders; Philadelphia: pp. 260–261. 2011
19	Drut RM and Drut R: Extracutaneous infantile haemangioma is also Glut1 positive. J Clin Pathol. 57:1197–1200. 2004. View Article : Google Scholar : PubMed/NCBI