Schwann cells differentiated from adipose‑derived stem cells for the treatment of brain contusion

  • Authors:
    • Liang Yang
    • Jiasheng Fang
    • Daguang Liao
    • Wei Wang
  • View Affiliations

  • Published online on: November 25, 2013     https://doi.org/10.3892/mmr.2013.1827
  • Pages: 567-573
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Abstract

Rapid development of tissue engineering techniques has led to the possibility of treating central nervous injuries with Schwann cells (SCs). However, certain characteristics of SCs, such as a low proliferation ability, greatly restrict their use. The aim of the present study was to investigate whether SCs differentiated from adipose‑derived stem cells (ADSC‑SCs) could used to promote functional recovery in brain contusion in rat. ADSCs were isolated and expanded from the groin of Sprague‑Dawley rats and differentiated into SCs. The ADSC‑SCs were transplanted into the contused rat brain and the locomotor function of the rats was assessed. Significant locomotor function recovery was observed in hemiparalyzed rats treated with ADSCs‑SCs. In conclusion, transplantation of ADSC‑SCs significantly promoted functional recovery following brain contusion.
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2014-February
Volume 9 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yang L, Fang J, Liao D and Wang W: Schwann cells differentiated from adipose‑derived stem cells for the treatment of brain contusion. Mol Med Rep 9: 567-573, 2014.
APA
Yang, L., Fang, J., Liao, D., & Wang, W. (2014). Schwann cells differentiated from adipose‑derived stem cells for the treatment of brain contusion. Molecular Medicine Reports, 9, 567-573. https://doi.org/10.3892/mmr.2013.1827
MLA
Yang, L., Fang, J., Liao, D., Wang, W."Schwann cells differentiated from adipose‑derived stem cells for the treatment of brain contusion". Molecular Medicine Reports 9.2 (2014): 567-573.
Chicago
Yang, L., Fang, J., Liao, D., Wang, W."Schwann cells differentiated from adipose‑derived stem cells for the treatment of brain contusion". Molecular Medicine Reports 9, no. 2 (2014): 567-573. https://doi.org/10.3892/mmr.2013.1827