Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (Review)

  • Authors:
    • Chen Liang
    • Ying-Yi Li
  • View Affiliations

  • Published online on: April 11, 2014     https://doi.org/10.3892/mmr.2014.2139
  • Pages: 2051-2060
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Abstract

Pim-1 is a proto-oncogene that encodes a serine/threonine kinase that is overexpressed in a range of haematopoietic malignancies and solid cancers. Pim-1 expression is tightly regulated by multiple biomolecules at different levels. Several lines of evidence have indicated that dysregulation of Pim-1 can interfere with the cell cycle and apoptosis to promote malignant transformation of a number of types of tumour. Thus, investigation of Pim-1 regulation may provide important theoretical guidance for the development of molecular targeting therapies and drug treatments for Pim-1‑associated diseases. Regulators of Pim-1 expression, include microRNAs, oestrogen, inecalcitol, adenosine triphosphate (ATP) mimetic inhibitors and ATP competitive inhibitors of Pim-1. Combinations of inhibitors of Pim-1 expression and Pim-1‑specific inhibitors may provide novel therapies for cancer patients and directions for cancer treatment.
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June-2014
Volume 9 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liang C and Li Y: Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (Review). Mol Med Rep 9: 2051-2060, 2014.
APA
Liang, C., & Li, Y. (2014). Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (Review). Molecular Medicine Reports, 9, 2051-2060. https://doi.org/10.3892/mmr.2014.2139
MLA
Liang, C., Li, Y."Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (Review)". Molecular Medicine Reports 9.6 (2014): 2051-2060.
Chicago
Liang, C., Li, Y."Use of regulators and inhibitors of Pim-1, a serine/threonine kinase, for tumour therapy (Review)". Molecular Medicine Reports 9, no. 6 (2014): 2051-2060. https://doi.org/10.3892/mmr.2014.2139