Open Access

Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage

  • Authors:
    • Tao Yang
    • Jianwen Gu
    • Bin Kong
    • Yongqin Kuang
    • Lin Cheng
    • Jingmin Cheng
    • Xun Xia
    • Yuan Ma
    • Junhai Zhang
  • View Affiliations

  • Published online on: July 25, 2014     https://doi.org/10.3892/mmr.2014.2421
  • Pages: 1671-1678
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The present study aimed to investigate the gene functions and expression profiles in perihematomal (PH) brain regions following spontaneous intracerebral hemorrhage. The gene expression profiles were downloaded from the Gene Expression Omnibus database under accession number GSE24265, which includes 11 brain samples from different regions, including four samples from PH areas, four from contralateral grey matter (CG) and three from contralateral white matter (CW). The gene expression profiles were pre-processed and the differentially expressed genes (DEGs) between PH and CG tissue, and PH and CW tissue were identified using R packages. The expression of genes in different tissues was analyzed by hierarchical clustering. Then, the interaction network between the DEGs was constructed using String software. Finally, Gene Ontology was performed and pathway analysis was conducted using FuncAssociate and Expression Analysis Systematic Explorer to identify the gene function. As a result, 399 DEGs were obtained between PH and CG, and 756 DEGs were identified between PH and CW. There were 35 common DEGs between the two groups. These DEGs may be involved in PH edema by regulating the calcium signaling pathway [calcium channel, voltage‑dependent, T-type, α1I subunit, Ca2+/calmodulin‑dependent protein kinase II α (CAMK2A), ryanodine receptor 2 (RYR2) and inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1)], cell proliferation (sphingosine kinase 1), neuron differentiation (Ephrin-A5) or extracellular matrix-receptor interaction [collagen, type I, α 2, laminin B1 (LAMB1), syndecan 2, fibronectin 1 and integrin α5 (ITGA5)]. A number of genes may cooperate to participate in the same pathway, such as ITPR1-RYR2, CAMK2A-RYR2 and ITGA5-LAMB1 interaction pairs. The present study provides several potential targets to decrease hematoma expansion and alleviate neuronal cell death following spontaneous intracerebral hemorrhage.
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October 2014
Volume 10 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yang T, Gu J, Kong B, Kuang Y, Cheng L, Cheng J, Xia X, Ma Y and Zhang J: Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage. Mol Med Rep 10: 1671-1678, 2014.
APA
Yang, T., Gu, J., Kong, B., Kuang, Y., Cheng, L., Cheng, J. ... Zhang, J. (2014). Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage. Molecular Medicine Reports, 10, 1671-1678. https://doi.org/10.3892/mmr.2014.2421
MLA
Yang, T., Gu, J., Kong, B., Kuang, Y., Cheng, L., Cheng, J., Xia, X., Ma, Y., Zhang, J."Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage". Molecular Medicine Reports 10.4 (2014): 1671-1678.
Chicago
Yang, T., Gu, J., Kong, B., Kuang, Y., Cheng, L., Cheng, J., Xia, X., Ma, Y., Zhang, J."Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage". Molecular Medicine Reports 10, no. 4 (2014): 1671-1678. https://doi.org/10.3892/mmr.2014.2421