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Intermittent cold stress enhances features of atherosclerotic plaque instability in apolipoprotein E‑deficient mice

  • Authors:
    • Xi Zheng
    • Qiang Wang
    • Yan Zhang
    • Dachun Yang
    • De Li
    • Bing  Tang
    • Xiuchuan Li
    • Yongjian Yang
    • Shuangtao Ma

  • View Affiliations

  • Published online on: August 7, 2014     https://doi.org/10.3892/mmr.2014.2464
  • Pages: 1679-1684
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The cold weather is associated with an increased occurrence of acute coronary events. However, the mechanisms underlying cold‑induced myocardial infarctions have not yet been fully elucidated. In the present study, 20 male, eight week‑old, apolipoprotein E (ApoE)‑deficient mice were subjected to either control conditions or intermittent cold exposure for eight weeks. Mice in the cold group were placed in a cold room at 4˚C for 4 h per day, while the mice in the control group were kept in a room at 24˚C. Cold‑exposed mice did not significantly differ from control mice in body weight, fasting glucose concentration and plasma lipid levels, including triglyceride, total cholesterol, low‑density lipoprotein and high‑density lipoprotein. The hematoxylin and eosin‑stained sections of the aortic root demonstrated increased plaque size in the cold group compared with the control group (P<0.01). Furthermore, cold‑treated mice exhibited significantly decreased plaque collagen and vascular smooth muscle cell deposition and increased macrophage and lymphocyte content (P<0.05 or P<0.01), which are typical features of atherosclerotic plaque instability. Additionally, the protein expression of matrix metalloproteinase (MMP)‑2, MMP‑9 and MMP‑14 were significantly increased (P<0.05 or P<0.01), whereas tissue inhibitor of matrix metalloproteinase (TIMP)‑1 expression was decreased (P<0.05) following exposure to a cold environment. The present study demonstrated that chronic intermittent cold stress may increase atherosclerotic plaque size and promote plaque instability in ApoE‑deficient mice by altering the balance of MMPs and TIMPs. These findings may provide mechanistic insights into sudden cardiac death in cold environments.
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October 2014
Volume 10 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Zheng X, Wang Q, Zhang Y, Yang D, Li D, Tang B, Li X, Yang Y and Ma S: Intermittent cold stress enhances features of atherosclerotic plaque instability in apolipoprotein E‑deficient mice. Mol Med Rep 10: 1679-1684, 2014
APA
Zheng, X., Wang, Q., Zhang, Y., Yang, D., Li, D., Tang, B. ... Ma, S. (2014). Intermittent cold stress enhances features of atherosclerotic plaque instability in apolipoprotein E‑deficient mice. Molecular Medicine Reports, 10, 1679-1684. https://doi.org/10.3892/mmr.2014.2464
MLA
Zheng, X., Wang, Q., Zhang, Y., Yang, D., Li, D., Tang, B., Li, X., Yang, Y., Ma, S."Intermittent cold stress enhances features of atherosclerotic plaque instability in apolipoprotein E‑deficient mice". Molecular Medicine Reports 10.4 (2014): 1679-1684.
Chicago
Zheng, X., Wang, Q., Zhang, Y., Yang, D., Li, D., Tang, B., Li, X., Yang, Y., Ma, S."Intermittent cold stress enhances features of atherosclerotic plaque instability in apolipoprotein E‑deficient mice". Molecular Medicine Reports 10, no. 4 (2014): 1679-1684. https://doi.org/10.3892/mmr.2014.2464