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Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population

  • Authors:
    • Rui Wang
    • Jun Zhang
    • Yanyun Ma
    • Linqi Chen
    • Shicheng Guo
    • Xiaojiao Zhang
    • Yunfang Ma
    • Lijun Wu
    • Xiaoyu Pei
    • Siran Liu
    • Jiucun Wang
    • Heping Hu
    • Jie Liu

  • View Affiliations

  • Published online on: September 4, 2014     https://doi.org/10.3892/mmr.2014.2536
  • Pages: 2736-2744
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Polymorphisms in pre‑microRNAs (miRNAs) or mature miRNAs may influence miRNA processing or target binding, thus contributing to tumorigenesis and cancer development. The present study aimed to evaluate whether miR‑149 rs2292832 (C>T) and miR‑608 rs4919510 (G>C) are associated with the risk and clinical characteristics of hepatocellular carcinoma (HCC) in a large‑scale population. miR‑149 rs2292832 and miR‑608 rs4919510 were genotyped in a total of 993 patients with HCC and 992 unrelated healthy subjects by Sequenom MassARRAY. The results showed that, compared with the reference CC genotype, the TC+TT genotype of miR‑149 was more highly associated with HCC [CC vs. TC+TT: Odds ratio (OR)=1.384, 95% confidence interval (CI)=1.013‑1.892, P=0.041], and was also associated with an increased risk of hepatitis B virus (HBV)‑associated HCC (CC vs. TC+TT: OR=1.453, 95% CI=1.034‑2.042, P=0.031). However, no significant association between miRNA‑608 rs4919510 and the risk of HCC/HBV‑associated HCC was found. In addition, these two SNPs were shown not to be correlated with a range of clinical characteristics. The present study may provide an indicator for identification of the high risk of HCC in patients.
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November-2014
Volume 10 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
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Spandidos Publications style
Wang R, Zhang J, Ma Y, Chen L, Guo S, Zhang X, Ma Y, Wu L, Pei X, Liu S, Liu S, et al: Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population. Mol Med Rep 10: 2736-2744, 2014.
APA
Wang, R., Zhang, J., Ma, Y., Chen, L., Guo, S., Zhang, X. ... Liu, J. (2014). Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population. Molecular Medicine Reports, 10, 2736-2744. https://doi.org/10.3892/mmr.2014.2536
MLA
Wang, R., Zhang, J., Ma, Y., Chen, L., Guo, S., Zhang, X., Ma, Y., Wu, L., Pei, X., Liu, S., Wang, J., Hu, H., Liu, J."Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population". Molecular Medicine Reports 10.5 (2014): 2736-2744.
Chicago
Wang, R., Zhang, J., Ma, Y., Chen, L., Guo, S., Zhang, X., Ma, Y., Wu, L., Pei, X., Liu, S., Wang, J., Hu, H., Liu, J."Association study of miR‑149 rs2292832 and miR‑608 rs4919510 and the risk of hepatocellular carcinoma in a large‑scale population". Molecular Medicine Reports 10, no. 5 (2014): 2736-2744. https://doi.org/10.3892/mmr.2014.2536