Inflammatory response in Parkinson's disease (Review)

  • Authors:
    • Junqiang Yan
    • Qizhi Fu
    • Liniu Cheng
    • Mingming Zhai
    • Wenjuan Wu
    • Lina Huang
    • Ganqin Du
  • View Affiliations

  • Published online on: September 12, 2014     https://doi.org/10.3892/mmr.2014.2563
  • Pages: 2223-2233
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Abstract

Parkinson's disease (PD) is one of the most common age‑related neurodegenerative diseases, which results from a number of environmental and inherited factors. PD is characterized by the slow progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. The nigrostriatal DA neurons are particularly vulnerable to inflammatory attack. Neuroinflammation is an important contributor to the pathogenesis of age‑related neurodegenerative disorders, such as PD, and as such anti‑inflammatory agents are becoming a novel therapeutic focus. This review will discuss the current knowledge regarding inflammation and review the roles of intracellular inflammatory signaling pathways, which are specific inflammatory mediators in PD. Finally, possible therapeutic strategies are proposed, which may downregulate inflammatory processes and inhibit the progression of PD.
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November-2014
Volume 10 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yan J, Fu Q, Cheng L, Zhai M, Wu W, Huang L and Du G: Inflammatory response in Parkinson's disease (Review). Mol Med Rep 10: 2223-2233, 2014.
APA
Yan, J., Fu, Q., Cheng, L., Zhai, M., Wu, W., Huang, L., & Du, G. (2014). Inflammatory response in Parkinson's disease (Review). Molecular Medicine Reports, 10, 2223-2233. https://doi.org/10.3892/mmr.2014.2563
MLA
Yan, J., Fu, Q., Cheng, L., Zhai, M., Wu, W., Huang, L., Du, G."Inflammatory response in Parkinson's disease (Review)". Molecular Medicine Reports 10.5 (2014): 2223-2233.
Chicago
Yan, J., Fu, Q., Cheng, L., Zhai, M., Wu, W., Huang, L., Du, G."Inflammatory response in Parkinson's disease (Review)". Molecular Medicine Reports 10, no. 5 (2014): 2223-2233. https://doi.org/10.3892/mmr.2014.2563