USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A

  • Authors:
    • Jianjun Xiong
    • Xiaoyuan Xu
    • Xiaou Zhou
    • Jianyun  Liu
    • Zhen Gong
    • Ping Wu
    • Weidong Li
  • View Affiliations

  • Published online on: October 15, 2014     https://doi.org/10.3892/mmr.2014.2666
  • Pages: 3343-3347
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The ubiquitin‑specific protease 22 (USP22) gene is overexpressed in the majority of types of cancer cells, and has been implicated in tumorigenesis. However, the mechanisms that regulate its expression remain unclear. The results of the present study demonstrated that the expression of USP22 is negatively regulated by trichostatin A (TSA), a classical histone deacetylase inhibitor. Furthermore, TSA was revealed to interfere with the binding of RNA polymerase II to the USP22 promoter, directly suppressing its transcription. In addition, the overexpression of USP22 was observed to attenuate TSA‑induced apoptosis in HeLa cells. To the best of our knowledge, these results provide the first insight into the regulation of the USP22 gene by antitumor drugs and into the mechanisms underlying the anticancer activity of TSA.
View Figures
View References

Related Articles

Journal Cover

December-2014
Volume 10 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xiong J, Xu X, Zhou X, Liu J, Gong Z, Wu P and Li W: USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. Mol Med Rep 10: 3343-3347, 2014.
APA
Xiong, J., Xu, X., Zhou, X., Liu, J., Gong, Z., Wu, P., & Li, W. (2014). USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A. Molecular Medicine Reports, 10, 3343-3347. https://doi.org/10.3892/mmr.2014.2666
MLA
Xiong, J., Xu, X., Zhou, X., Liu, J., Gong, Z., Wu, P., Li, W."USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A". Molecular Medicine Reports 10.6 (2014): 3343-3347.
Chicago
Xiong, J., Xu, X., Zhou, X., Liu, J., Gong, Z., Wu, P., Li, W."USP22 transcriptional activity is negatively regulated by the histone deacetylase inhibitor trichostatin A". Molecular Medicine Reports 10, no. 6 (2014): 3343-3347. https://doi.org/10.3892/mmr.2014.2666