Open Access

Epigenetic alterations in gastric cancer (Review)

  • Authors:
    • Du-Guan Fu
  • View Affiliations

  • Published online on: May 22, 2015     https://doi.org/10.3892/mmr.2015.3816
  • Pages: 3223-3230
  • Copyright: © Fu . This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Gastric cancer is one of the most common types of cancer and the second most common cause of cancer-related mortality worldwide. An increasing number of recent studies have confirmed that gastric cancer is a multistage pathological state that arises from environmental factors; dietary factors in particulary are considered to play an important role in the etiology of gastric cancer. Improper dietary habits are one of the primary concerns as they influence key molecular events associated with the onset of gastric carcinogenesis. In the field of genetics, anticancer research has mainly focused on the various genetic markers and genetic molecular mechanisms responsible for the development of this of this disease. Some of this research has proven to be very fruitful, providing insight into the possible mechamisms repsonsible for this disease and into possible treatment modalities. However, the mortality rate associated with gastric cancer remains relatively high. Thus, epigenetics has become a hot topic for research, whereby genetic markers are bypassed and this research is directed towards reversible epigenetic events, such as methylation and histone modifications that play a crucial role in carcinogenesis. The present review focuses on the epigenetic events which play an important role in the development and progression of this deadly disease, gastric cancer.
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September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Fu D: Epigenetic alterations in gastric cancer (Review). Mol Med Rep 12: 3223-3230, 2015.
APA
Fu, D. (2015). Epigenetic alterations in gastric cancer (Review). Molecular Medicine Reports, 12, 3223-3230. https://doi.org/10.3892/mmr.2015.3816
MLA
Fu, D."Epigenetic alterations in gastric cancer (Review)". Molecular Medicine Reports 12.3 (2015): 3223-3230.
Chicago
Fu, D."Epigenetic alterations in gastric cancer (Review)". Molecular Medicine Reports 12, no. 3 (2015): 3223-3230. https://doi.org/10.3892/mmr.2015.3816