Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge

Shin,Na‑Rae; Shin,In‑Sik; Jeon,Chan‑Mi; Hong,Ju‑Mi; Kwon,Ok‑Kyoung; Kim,Hui‑Seong; Oh,Sei‑Ryang; Hahn,Kyu‑Woung; Ahn,Kyung‑Seop

doi:10.3892/mmr.2015.3914

Zingiber mioga (Thunb.) Roscoe attenuates allergic asthma induced by ovalbumin challenge

Authors:
- Na‑Rae Shin
- In‑Sik Shin
- Chan‑Mi Jeon
- Ju‑Mi Hong
- Ok‑Kyoung Kwon
- Hui‑Seong Kim
- Sei‑Ryang Oh
- Kyu‑Woung Hahn
- Kyung‑Seop Ahn
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Affiliations: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon‑Gun, Chungbuk 363‑883, Republic of Korea, Department of Biological Science and Biotechnology, Hannam University, Yuesong‑Gu, Daejeon 305‑811, Republic of Korea
Published online on: June 11, 2015 https://doi.org/10.3892/mmr.2015.3914
Pages: 4538-4545

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Abstract

Zingiber mioga (Thunb.) Roscoe (ZM) is a traditional medicine, used to treat inflammatory diseases. The present study aimed to evaluate the inhibitory effects of ZM on the inflammatory response in lipopolysaccharide (LPS)‑stimulated RAW264.7 murine macrophage cells and in a mouse model of ovalbumin (OVA)‑induced allergic asthma. Mice received OVA sensitization on day 0 and 14, and were challenged with OVA between days 21 and 23. ZM was administered to the mice at a dose of 30 mg/kg, 1 h prior to OVA challenge. In LPS‑stimulated RAW264.7 cells, ZM significantly decreased nitric oxide (NO) and tumor necrosis factor (TNF)‑α production in a concentration‑dependent manner, and mRNA expression of inducible NO synthase (iNOS), TNF‑α and matrix metalloproteinase (MMP)‑9 was reduced. In addition, treatment with ZM decreased the inflammatory cell count in bronchoalveolar lavage fluid from the mice, and reduced the expression of interleukin (IL)‑4, IL‑5, IL‑13, eotaxin and immunoglobulin E. ZM also reduced airway hyperresponsiveness in OVA‑challenged mice, and attenuated the infiltration of inflammatory cells and mucus production in the airways, with a decrease in the expression of iNOS and MMP‑9 in lung tissue. In conclusion, the results of the present study indicate that ZM effectively inhibits inflammatory responses. Therefore, it may be that ZM has potential as a therapeutic agent for use in inflammatory diseases.

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