Open Access

Structure and function of Gab2 and its role in cancer (Review)

  • Authors:
    • Chen‑Bo Ding
    • Wei‑Na Yu
    • Ji‑Hong Feng
    • Jun‑Min Luo
  • View Affiliations

  • Published online on: June 17, 2015     https://doi.org/10.3892/mmr.2015.3951
  • Pages: 4007-4014
  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The docking proteins of the Grb-associated binder (Gab) family transduce cellular signals between receptors and intracellular downstream effectors, and provide a platform for protein‑protein interactions. Gab2, a key member of the Gab family of proteins, is involved in the amplification and integration of signal transduction, evoked by a variety of extracellular stimuli, including growth factors, cytokines and antigen receptors. Gab2 protein lacks intrinsic catalytic activity; however, when phosphorylated by protein‑tyrosine kinases (PTKs), Gab2 recruits several Src homology‑2 (SH2) domain‑containing proteins, including the SH2‑containing protein tyrosine phosphatase 2 (SHP2), the p85 subunit of phosphoinositide‑3 kinase (PI3K), phospholipase C‑γ (PLCγ)1, Crk, and GC‑GAP. Through these interactions, the Gab2 protein triggers various downstream signal effectors, including SHP2/rat sarcoma viral oncogene/RAF/mitogen‑activated protein kinase kinase/extracellular signal‑regulated kinase and PI3K/AKT, involved in cell growth, differentiation, migration and apoptosis. It has been previously reported that aberrant Gab2 and/or Gab2 signaling is closely associated with human tumorigenesis, particularly in breast cancer, leukemia and melanoma. The present review aimed to focus on the structure and effector function of Gab2, its role in cancer and its potential for use as an effective therapeutic target.
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September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Ding CB, Yu WN, Feng JH and Luo JM: Structure and function of Gab2 and its role in cancer (Review). Mol Med Rep 12: 4007-4014, 2015.
APA
Ding, C., Yu, W., Feng, J., & Luo, J. (2015). Structure and function of Gab2 and its role in cancer (Review). Molecular Medicine Reports, 12, 4007-4014. https://doi.org/10.3892/mmr.2015.3951
MLA
Ding, C., Yu, W., Feng, J., Luo, J."Structure and function of Gab2 and its role in cancer (Review)". Molecular Medicine Reports 12.3 (2015): 4007-4014.
Chicago
Ding, C., Yu, W., Feng, J., Luo, J."Structure and function of Gab2 and its role in cancer (Review)". Molecular Medicine Reports 12, no. 3 (2015): 4007-4014. https://doi.org/10.3892/mmr.2015.3951