Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)

Zou,Junrong; Guo,Pei; Lv,Nonghua; Huang,Deqiang

doi:10.3892/mmr.2015.4243

Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)

Authors:
- Junrong Zou
- Pei Guo
- Nonghua Lv
- Deqiang Huang
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Affiliations: Research Institute of Digestive Diseases, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
Published online on: August 25, 2015 https://doi.org/10.3892/mmr.2015.4243
Pages: 6399-6404

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Abstract

Lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) exerts transcription factor activity and is involved in protein quality control. LITAF activity is highly dependent on correct translocation from the endosome/lysosome to the nucleus, while certain LITAF mutants mislocalize to areas, such as the cytosol and mitochondria, resulting in developmental diseases. In addition, previous studies have proposed that LITAF functions as a tumor suppressor and is frequently under‑represented in certain types of cancer. However, the mechanism of this phenomenon remains unclear. The present review summarizes the major advances in LITAF studies, and proposes that LITAF may serve as a switch in the balance between classical and alternative activation in tumor associated‑inflammation. Thus, LITAF may be a promising therapeutic target with regard to the tumor microenvironment.

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