Open Access

OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats

  • Authors:
    • Chan‑Sik Kim
    • Junghyun Kim
    • Kyuhyung Jo
    • Yun Mi Lee
    • Eunjin Sohn
    • Nam Hee Yoo
    • Jin Sook Kim
  • View Affiliations

  • Published online on: October 1, 2015     https://doi.org/10.3892/mmr.2015.4413
  • Pages: 7279-7284
  • Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood‑retinal barrier (BRB) and retinal neovascularization; however, how AGEs affect the retina has largely remained elusive. OSSC1E‑K19 is a novel phytochemical component of Osteomeles schwerinae. The objective of the present study was to evaluate the protective effects of OSSC1E‑K19 on retinal vascular injury in AGE‑modified rat serum albumin (AGE-RSA)-induced retinopathy. AGE-RSA-injected rat eyes were used investigate the protective effects of OSSC1E‑K19 on BRB breakdown. Intravitreal injection of OSSC1E-K19 prevented AGE-RSA-induced BRB breakdown and decreased retinal VEGF expression in retinal vessels. In addition, OSSC1E-K19 inhibited the loss of occludin, a significant tight junction protein. These results supported the potential therapeutic utility of OSSC1E-K19 for retinal vascular permeability diseases.
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November-2015
Volume 12 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Kim CS, Kim J, Jo K, Lee YM, Sohn E, Yoo NH and Kim JS: OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats. Mol Med Rep 12: 7279-7284, 2015.
APA
Kim, C., Kim, J., Jo, K., Lee, Y.M., Sohn, E., Yoo, N.H., & Kim, J.S. (2015). OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats. Molecular Medicine Reports, 12, 7279-7284. https://doi.org/10.3892/mmr.2015.4413
MLA
Kim, C., Kim, J., Jo, K., Lee, Y. M., Sohn, E., Yoo, N. H., Kim, J. S."OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats". Molecular Medicine Reports 12.5 (2015): 7279-7284.
Chicago
Kim, C., Kim, J., Jo, K., Lee, Y. M., Sohn, E., Yoo, N. H., Kim, J. S."OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats". Molecular Medicine Reports 12, no. 5 (2015): 7279-7284. https://doi.org/10.3892/mmr.2015.4413