Critical role of miRNAs in mediating skeletal muscle atrophy (Review)

  • Authors:
    • Yonghui Yu
    • Wanli Chu
    • Jiake Chai
    • Xiao Li
    • Lingying Liu
    • Li Ma
  • View Affiliations

  • Published online on: December 30, 2015     https://doi.org/10.3892/mmr.2015.4748
  • Pages: 1470-1474
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Skeletal muscle atrophy, a conventional clinical feature in patients with cancer, chronic obstructive pulmonary disease, sepsis and severe burns, is defined as a reduction in muscle mass. During atrophy, the protein degradation is abnormally activated and the aberrance between protein synthesis and protein degradation results in muscle atrophy. Previous studies have demonstrated that miRNAs, small non‑coding RNA molecules, serve an important role in the regulation of muscle atrophy. Further studies have indicated the implications of the ubiquitin‑proteasome and PI3K/Akt/FoxO signaling pathways and myogenic regulatory factors in miRNA‑mediated muscle atrophy. Therefore, in this review, the effects and molecular mechanisms of miRNAs on muscle atrophy are summarized, leading to the suggestion that miRNAs may serve as potential therapeutic targets in muscle atrophy.
View Figures
View References

Related Articles

Journal Cover

February-2016
Volume 13 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Chu W, Chai J, Li X, Liu L and Ma L: Critical role of miRNAs in mediating skeletal muscle atrophy (Review). Mol Med Rep 13: 1470-1474, 2016.
APA
Yu, Y., Chu, W., Chai, J., Li, X., Liu, L., & Ma, L. (2016). Critical role of miRNAs in mediating skeletal muscle atrophy (Review). Molecular Medicine Reports, 13, 1470-1474. https://doi.org/10.3892/mmr.2015.4748
MLA
Yu, Y., Chu, W., Chai, J., Li, X., Liu, L., Ma, L."Critical role of miRNAs in mediating skeletal muscle atrophy (Review)". Molecular Medicine Reports 13.2 (2016): 1470-1474.
Chicago
Yu, Y., Chu, W., Chai, J., Li, X., Liu, L., Ma, L."Critical role of miRNAs in mediating skeletal muscle atrophy (Review)". Molecular Medicine Reports 13, no. 2 (2016): 1470-1474. https://doi.org/10.3892/mmr.2015.4748