1
|
Pei JJ, Giron MS, Jia J and Wang HX:
Dementia studies in Chinese populations. Neurosci Bull. 30:207–216.
2014. View Article : Google Scholar : PubMed/NCBI
|
2
|
Radi E, Formichi P, Battisti C and
Federico A: Apoptosis and oxidative stress in neurodegenerative
diseases. J Alzheimers Dis. 42(Suppl 3): S125–S152. 2014.PubMed/NCBI
|
3
|
Ghaffari H, Venkataramana M, Jalali
Ghassam B, Chandra Nayaka S, Nataraju A, Geetha NP and Prakash HS:
Rosmarinic acid mediated neuroprotective effects against HO-induced
neuronal cell damage in N2A cells. Life Sci. 113:7–13. 2014.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Surh YJ: Cancer chemoprevention with
dietary phytochemicals. Nat Rev Cancer. 3:768–780. 2003. View Article : Google Scholar : PubMed/NCBI
|
5
|
Diao Y, Lin XM, Liao CL, Tang CZ, Chen ZJ
and Hu ZL: Authentication of Panax ginseng from its adulterants by
PCR-RFLP and ARMS. Planta Med. 75:557–560. 2009. View Article : Google Scholar : PubMed/NCBI
|
6
|
Qin JH, Leung FC, Fung Y, Zhu D and Lin B:
Rapid authentication of ginseng species using microchip
electrophoresis with laser-induced fluorescence detection. Anal
Bioanal Chem. 381:812–819. 2005. View Article : Google Scholar : PubMed/NCBI
|
7
|
Lu JM, Yao Q and Chen C: Ginseng
compounds: An update on their molecular mechanisms and medical
applications. Curr Vasc Pharmacol. 7:293–302. 2009. View Article : Google Scholar : PubMed/NCBI
|
8
|
Rausch WD, Liu S, Gille G and Radad K:
Neuroprotective effects of ginsenosides. Acta Neurobiol Exp (Wars).
66:369–375. 2006.
|
9
|
Liu ZQ: Chemical insights into ginseng as
a resource for natural antioxidants. Chem Rev. 112:3329–3355. 2012.
View Article : Google Scholar : PubMed/NCBI
|
10
|
Ru W, Wang D, Xu Y, He X, Sun YE, Qian L,
Zhou X and Qin Y: Chemical constituents and bioactivities of Panax
ginseng (C. A. Mey.). Drug Discov Ther. 9:23–32. 2015. View Article : Google Scholar : PubMed/NCBI
|
11
|
Zhang YF, Fan XJ, Li X, Peng LL, Wang GH,
Ke KF and Jiang ZL: Ginsenoside Rg1 protects neurons from
hypoxic-ischemic injury possibly by inhibiting Ca2+ influx through
NMDA receptors and L-type voltage-dependent Ca2+ channels. Eur J
Pharmacol. 586:90–99. 2008. View Article : Google Scholar : PubMed/NCBI
|
12
|
Ni N, Liu Q, Ren H, Wu D, Luo C, Li P, Wan
JB and Su H: Ginsenoside Rb1 protects rat neural progenitor cells
against oxidative injury. Molecules. 19:3012–3024. 2014. View Article : Google Scholar : PubMed/NCBI
|
13
|
Chen Z, Lu T, Yue X, Wei N, Jiang Y, Chen
M, Ni G, Liu X and Xu G: Neuroprotective effect of ginsenoside Rb1
on glutamate-induced neurotoxicity: With emphasis on autophagy.
Neurosci Lett. 482:264–268. 2010. View Article : Google Scholar : PubMed/NCBI
|
14
|
Luo T, Liu G, Ma H, Lu B, Xu H, Wang Y, Wu
J, Ge P and Liang J: Inhibition of autophagy via activation of
PI3K/Akt pathway contributes to the protection of ginsenoside Rb1
against neuronal death caused by ischemic insults. Int J Mol Sci.
15:15426–15442. 2014. View Article : Google Scholar : PubMed/NCBI
|
15
|
Liu J, He J, Huang L, Dou L, Wu S and Yuan
Q: Neuroprotective effects of ginsenoside Rb1 on hippocampal
neuronal injury and neurite outgrowth. Neural Regen Res. 9:943–950.
2014. View Article : Google Scholar : PubMed/NCBI
|
16
|
Hashimoto R, Yu J, Koizumi H, Ouchi Y and
Okabe T: Ginsenoside Rb1 Prevents MPP(+)-Induced Apoptosis in PC12
Cells by Stimulating Estrogen Receptors with Consequent Activation
of ERK1/2, Akt and Inhibition of SAPK/JNK, p38 MAPK. Evid Based
Complement Alternat Med. 2012:6937172012. View Article : Google Scholar : PubMed/NCBI
|
17
|
Ye R, Yang Q, Kong X, Han J, Zhang X,
Zhang Y, Li P, Liu J, Shi M, Xiong L and Zhao G: Ginsenoside Rd
attenuates early oxidative damage and sequential inflammatory
response after transient focal ischemia in rats. Neurochem Int.
58:391–398. 2011. View Article : Google Scholar
|
18
|
Leung KW, Yung KK, Mak NK, Chan YS, Fan TP
and Wong RN: Neuroprotective effects of ginsenoside-Rg1 in primary
nigral neurons against rotenone toxicity. Neuropharmacology.
52:827–835. 2007. View Article : Google Scholar
|
19
|
Fang F, Chen X, Huang T, Lue LF, Luddy JS
and Yan SS: Multi-faced neuroprotective effects of Ginsenoside Rg1
in an Alzheimer mouse model. Biochim Biophys Acta. 1822:286–292.
2012. View Article : Google Scholar :
|
20
|
Xu BB, Liu CQ, Gao X, Zhang WQ, Wang SW
and Cao YL: Possible mechanisms of the protection of ginsenoside Re
against MPTP-induced apoptosis in substantia nigra neurons of
Parkinson's disease mouse model. J Asian Nat Prod Res. 7:215–224.
2005. View Article : Google Scholar
|
21
|
Leipzig ND, Wylie RG, Kim H and Shoichet
MS: Differentiation of neural stem cells in three-dimensional
growth factor-immobilized chitosan hydrogel scaffolds.
Biomaterials. 32:57–64. 2011. View Article : Google Scholar
|
22
|
Gage FH: Mammalian neural stem cells.
Science. 287:1433–1438. 2000. View Article : Google Scholar : PubMed/NCBI
|
23
|
Alvarez-Buylla A and Garcia-Verdugo JM:
Neurogenesis in adult subventricular zone. J Neurosci. 22:629–634.
2002.PubMed/NCBI
|
24
|
Reynolds BA and Weiss S: Generation of
neurons and astrocytes from isolated cells of the adult mammalian
central nervous system. Science. 255:1707–1710. 1992. View Article : Google Scholar : PubMed/NCBI
|
25
|
Su HX, Zhang W, Guo J, Guo A, Yuan Q and
Wu W: Neural progenitor cells enhance the survival and axonal
regeneration of injured motoneurons after transplantation into the
avulsed ventral horn of adult rats. J Neurotrauma. 26:67–80. 2009.
View Article : Google Scholar : PubMed/NCBI
|
26
|
Kučera O, Endlicher R, Roušar T, Lotková
H, Garnol T, Drahota Z and Cervinková Z: The effect of tert-butyl
hydroperoxide-induced oxidative stress on lean and steatotic rat
hepatocytes in vitro. Oxid Med Cell Longev. 2014:7525062014.
View Article : Google Scholar
|
27
|
Koh JY and Choi DW: Quantitative
determination of glutamate mediated cortical neuronal injury in
cell culture by lactate dehydrogenase efflux assay. J Neurosci
Methods. 20:83–90. 1987. View Article : Google Scholar : PubMed/NCBI
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2−ΔΔCt method. Methods. 25:402–408. 2001. View Article : Google Scholar
|
29
|
Aueviriyavit S, Phummiratch D and
Maniratanachote R: Mechanistic study on the biological effects of
silver and gold nanoparticles in Caco-2 cells-induction of the
Nrf2/HO-1 pathway by high concentrations of silver nanoparticles.
Toxicol Lett. 224:73–83. 2014. View Article : Google Scholar
|
30
|
Buettner C, Yeh GY, Phillips RS, Mittleman
MA and Kaptchuk TJ: Systematic review of the effects of ginseng on
cardiovascular risk factors. Ann Pharmacother. 40:83–95. 2006.
View Article : Google Scholar
|
31
|
Gillis CN: Panax ginseng pharmacology: A
nitric oxide link? Biochem Pharmacol. 54:1–8. 1997. View Article : Google Scholar : PubMed/NCBI
|
32
|
Hofseth LJ and Wargovich MJ: Inflammation,
cancer and targets of ginseng. J Nutr. 137(Suppl 1): 183S–185S.
2007.
|
33
|
Attele AS, Wu JA and Yuan CS: Ginseng
pharmacology: Multiple constituents and multiple actions. Biochem
Pharmacol. 58:1685–1693. 1999. View Article : Google Scholar : PubMed/NCBI
|
34
|
Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q
and Chen CJ: Molecular mechanisms and clinical applications of
ginseng root for cardiovascular disease. Med Sci Monit.
10:RA187–RA192. 2004.PubMed/NCBI
|
35
|
Cheng Y, Shen LH and Zhang JT:
Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and
its mechanism of action. Acta Pharmacol Sin. 26:143–149. 2005.
View Article : Google Scholar : PubMed/NCBI
|
36
|
Murthy HN, Georgiev MI, Kim YS, Jeong CS,
Kim SJ and Park SY: Ginsenosides: Prospective for sustainable
biotechnological production. Appl Microbiol Biotechnol.
98:6243–6254. 2014. View Article : Google Scholar : PubMed/NCBI
|
37
|
Alfadda AA and Sallam RM: Reactive oxygen
species in health and disease. J Biomed Biotechnol.
2012:9364862012. View Article : Google Scholar : PubMed/NCBI
|
38
|
Smith JA, Park S, Krause JS and Banik NL:
Oxidative stress, DNA damage and the telomeric complex as
therapeutic targets in acute neurodegeneration. Neurochem Int.
62:764–775. 2013. View Article : Google Scholar : PubMed/NCBI
|
39
|
Fernández-Gajardo R, Matamala JM, Carrasco
R, Gutiérrez R, Melo R and Rodrigo R: Novel therapeutic strategies
for traumatic brain injury: Acute antioxidant reinforcement. CNS
Drugs. 28:229–248. 2014. View Article : Google Scholar : PubMed/NCBI
|
40
|
Xie JT, Shao ZH, Hoek TL, Chang WT, Li J,
Mehendale S, Wang CZ, Hsu CW, Becker LB, Yin JJ and Yuan CS:
Antioxidant effects of ginsenoside Re in cardiomyocytes. Eur J
Pharmacol. 532:201–207. 2006. View Article : Google Scholar : PubMed/NCBI
|
41
|
Lim JH, Wen TC, Matsuda S, Tanaka J, Maeda
N, Peng H, Aburaya J, Ishihara K and Sakanaka M: Protection of
ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient
of ginseng root. Neurosci Res. 28:191–200. 1997. View Article : Google Scholar : PubMed/NCBI
|
42
|
Tian J, Fu F, Geng M, Jiang Y, Yang J,
Jiang W, Wang C and Liu K: Neuroprotective effect of
20(S)-ginsenoside Rg3 on cerebral ischemia in rats. Neurosci Lett.
374:92–97. 2005. View Article : Google Scholar : PubMed/NCBI
|
43
|
Zhao H, Li Q, Zhang Z, Pei X, Wang J and
Li Y: Long-term ginsenoside consumption prevents memory loss in
aged SAMP8 mice by decreasing oxidative stress and up-regulating
the plasticity-related proteins in hippocampus. Brain Res.
1256:111–122. 2009. View Article : Google Scholar : PubMed/NCBI
|
44
|
Liu ZQ, Luo XY, Liu GZ, Chen YP, Wang ZC
and Sun YX: In vitro study of the relationship between the
structure of ginsenoside and its antioxidative or prooxidative
activity in free radical induced hemolysis of human erythrocytes. J
Agric Food Chem. 51:2555–2558. 2003. View Article : Google Scholar : PubMed/NCBI
|
45
|
Liu ZQ, Luo XY, Sun YX, Chen YP and Wang
ZC: Can ginsenosides protect human erythrocytes against
free-radical-induced hemolysis? Biochim Biophys Acta. 1572:58–66.
2002. View Article : Google Scholar : PubMed/NCBI
|
46
|
Liu D, Zhang H, Gu W, Liu Y and Zhang M:
Neuroprotective effects of ginsenoside Rb1 on high glucose-induced
neurotoxicity in primary cultured rat hippocampal neurons. PLoS
One. 8:e793992013. View Article : Google Scholar : PubMed/NCBI
|
47
|
Liu Z, Chen J, Huang W, Zeng Z, Yang Y and
Zhu B: Ginsenoside Rb1 protects rat retinal ganglion cells against
hypoxia and oxidative stress. Mol Med Rep. 8:1397–1403.
2013.PubMed/NCBI
|
48
|
Tan SJ, Yu Z and Dong QT: Effects of
ginsenoside Rb1 on the oxidative stress in the skeletal muscles of
rats with postoperative fatigue syndrome. Zhongguo Zhong Xi Yi Jie
He Za Zhi. 32:1535–1538. 2012.In Chinese.
|
49
|
Wu Y, Xia ZY, Dou J, Zhang L, Xu JJ, Zhao
B, Lei S and Liu HM: Protective effect of ginsenoside Rb1 against
myocardial ischemia/reperfusion injury in streptozotocin-induced
diabetic rats. Mol Biol Rep. 38:4327–4335. 2011. View Article : Google Scholar
|
50
|
Migliore L and Coppedè F:
Environmental-induced oxidative stress in neurodegenerative
disorders and aging. Mutat Res. 674:73–84. 2009. View Article : Google Scholar
|
51
|
Li J, O W, Li W, Jiang ZG and Ghanbari HA:
Oxidative stress and neurodegenerative disorders. Int J Mol Sci.
14:24438–24475. 2013. View Article : Google Scholar : PubMed/NCBI
|
52
|
Xie Y, Zhao QY, Li HY, Zhou X, Liu Y and
Zhang H: Curcumin ameliorates cognitive deficits heavy ion
irradiation-induced learning and memory deficits through enhancing
of Nrf2 antioxidant signaling pathways. Pharmacol Biochem Behav.
126:181–186. 2014. View Article : Google Scholar : PubMed/NCBI
|
53
|
Li W and Kong AN: Molecular mechanisms of
Nrf2-mediated antioxidant response. Mol Carcinog. 48:91–104. 2009.
View Article : Google Scholar :
|
54
|
Li B, Choi HJ, Lee DS, Oh H, Kim YC, Moon
JY, Park WH, Park SD and Kim JE: Amomum tsao-ko Suppresses
lipopoly-saccharide-induced inflammatory responses in RAW264.7
macrophages via Nrf2-dependent heme oxygenase-1 expression. Am J
Chin Med. 42:1229–1244. 2014. View Article : Google Scholar
|
55
|
Was H, Dulak J and Jozkowicz A: Heme
oxygenase-1 in tumor biology and therapy. Curr Drug Targets.
11:1551–1570. 2010. View Article : Google Scholar : PubMed/NCBI
|
56
|
Wu ML, Ho YC, Lin CY and Yet SF: Heme
oxygenase-1 in inflammation and cardiovascular disease. Am J
Cardiovasc Dis. 1:150–158. 2011.
|
57
|
Tkachev VO, Menshchikova EB and Zenkov NK:
Mechanism of the Nrf2/Keap1/ARE signaling system. Biochemistry
(Mosc). 76:407–422. 2011. View Article : Google Scholar
|
58
|
Zenkov NK, Menshchikova EB and Tkachev VO:
Keap1/Nrf2/ARE redox-sensitive signaling system as a
pharmacological target. Biochemistry (Mosc). 78:19–36. 2013.
View Article : Google Scholar
|
59
|
Dinkova-Kostova AT, Holtzclaw WD and
Kensler TW: The role of Keap1 in cellular protective responses.
Chem Res Toxicol. 18:1779–1791. 2005. View Article : Google Scholar : PubMed/NCBI
|