Open Access

MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review)

  • Authors:
    • Shuping Peng
    • Dan Gao
    • Chengde Gao
    • Pingpin Wei
    • Man Niu
    • Cijun Shuai
  • View Affiliations

  • Published online on: May 24, 2016     https://doi.org/10.3892/mmr.2016.5335
  • Pages: 623-629
  • Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Osteogenesis is a complex multi-step process involving the differentiation of mesenchymal stem cells (MSCs) into osteoblast progenitor cells, preosteoblasts, osteoblasts and osteocytes, and the crosstalk between multiple cell types for the formation and remodeling of bone. The signaling regulatory networks during osteogenesis include various components, including growth factors, transcription factors, micro (mi)RNAs and effectors, a number of which form feedback loops controlling the balance of osteogenic differentiation by positive or negative regulation. miRNAs have been found to be important regulators of osteogenic signaling pathways in multiple aspects and multiple signaling pathways. The present review focusses on the progress in elucidating the role of miRNA in the osteogenesis signaling networks of MSCs as a substitute for bone implantation the the field of bone tissue engineering. In particular, the review classifies which miRNAs promote or suppress the osteogenic process, and summarizes which signaling pathway these miRNAs are involved in. Improvements in knowledge of the characteristics of miRNAs in osteogenesis provide an important step for their application in translational investigations of bone tissue engineering and bone disease.
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July-2016
Volume 14 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Peng S, Gao D, Gao C, Wei P, Niu M and Shuai C: MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review). Mol Med Rep 14: 623-629, 2016.
APA
Peng, S., Gao, D., Gao, C., Wei, P., Niu, M., & Shuai, C. (2016). MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review). Molecular Medicine Reports, 14, 623-629. https://doi.org/10.3892/mmr.2016.5335
MLA
Peng, S., Gao, D., Gao, C., Wei, P., Niu, M., Shuai, C."MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review)". Molecular Medicine Reports 14.1 (2016): 623-629.
Chicago
Peng, S., Gao, D., Gao, C., Wei, P., Niu, M., Shuai, C."MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review)". Molecular Medicine Reports 14, no. 1 (2016): 623-629. https://doi.org/10.3892/mmr.2016.5335