Open Access

Notch signaling in cerebrovascular diseases (Review)

  • Authors:
    • Zhiyou Cai
    • Bin Zhao
    • Yanqing Deng
    • Shouqin Shangguan
    • Faming Zhou
    • Wenqing Zhou
    • Xiaoli Li
    • Yanfeng Li
    • Guanghui Chen
  • View Affiliations

  • Published online on: August 19, 2016     https://doi.org/10.3892/mmr.2016.5641
  • Pages: 2883-2898
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The Notch signaling pathway is a crucial regulator of numerous fundamental cellular processes. Increasing evidence suggests that Notch signaling is involved in inflammation and oxidative stress, and thus in the progress of cerebrovascular diseases. In addition, Notch signaling in cerebrovascular diseases is associated with apoptosis, angiogenesis and the function of blood‑brain barrier. Despite the contradictory results obtained to date as to whether Notch signaling is harmful or beneficial, the regulation of Notch signaling may provide a novel strategy for the treatment of cerebrovascular diseases.
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October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Cai Z, Zhao B, Deng Y, Shangguan S, Zhou F, Zhou W, Li X, Li Y and Chen G: Notch signaling in cerebrovascular diseases (Review). Mol Med Rep 14: 2883-2898, 2016.
APA
Cai, Z., Zhao, B., Deng, Y., Shangguan, S., Zhou, F., Zhou, W. ... Chen, G. (2016). Notch signaling in cerebrovascular diseases (Review). Molecular Medicine Reports, 14, 2883-2898. https://doi.org/10.3892/mmr.2016.5641
MLA
Cai, Z., Zhao, B., Deng, Y., Shangguan, S., Zhou, F., Zhou, W., Li, X., Li, Y., Chen, G."Notch signaling in cerebrovascular diseases (Review)". Molecular Medicine Reports 14.4 (2016): 2883-2898.
Chicago
Cai, Z., Zhao, B., Deng, Y., Shangguan, S., Zhou, F., Zhou, W., Li, X., Li, Y., Chen, G."Notch signaling in cerebrovascular diseases (Review)". Molecular Medicine Reports 14, no. 4 (2016): 2883-2898. https://doi.org/10.3892/mmr.2016.5641