Open Access

Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury

  • Authors:
    • Yang Wang
    • Chunhu Zhang
    • Weijun Peng
    • Zian Xia
    • Pingping Gan
    • Wei Huang
    • Yafei Shi
    • Rong Fan
  • View Affiliations

  • Published online on: September 6, 2016     https://doi.org/10.3892/mmr.2016.5720
  • Pages: 3690-3696
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Free radical-induced oxidative damage occurs rapidly and is of primary importance during the secondary pathophysiological cascades of traumatic brain injury (TBI). Hydroxysafflor yellow A (HSYA) is a constituent of the flower petals of Carthamus tinctorius (safflower) and may represent a potential therapeutic strategy to improve outcomes following TBI. The present study aimed to identify HSYA in the brain tissues of rats exposed to TBI to determine its absorption and to investigate the underlying effects of HSYA on antioxidant enzymes in the brain tissues of TBI rats. To determine the absorption of HSYA for the investigation of the underlying antioxidant effects of HSYA in TBI, the presence of HSYA in the brain tissues of the TBI rats was identified using an ultra performance liquid chromatography‑tandem mass spectrometry method. Subsequently, the state of oxidative stress in the TBI rat model following the administration of HSYA was investigated by determining the levels of antioxidant enzymes, including superoxide dismutase (SOD), malondialdehyde (MDA) and catalase (CAT), and the ratio of glutathione (GSH)/glutathione disulfide (GSSG). The data obtained demonstrated that HSYA was absorbed in the brain tissues of the TBI rats. HSYA increased the activities of SOD and CAT, the level of GSH and the GSH/GSSG ratio. However, HSYA concomitantly decreased the levels of MDA and GSSG. These preliminary data suggest that HSYA has the potential to be utilized as a neuroprotective drug in cases of TBI.
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October-2016
Volume 14 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang Y, Zhang C, Peng W, Xia Z, Gan P, Huang W, Shi Y and Fan R: Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury. Mol Med Rep 14: 3690-3696, 2016.
APA
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W. ... Fan, R. (2016). Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury. Molecular Medicine Reports, 14, 3690-3696. https://doi.org/10.3892/mmr.2016.5720
MLA
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W., Shi, Y., Fan, R."Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury". Molecular Medicine Reports 14.4 (2016): 3690-3696.
Chicago
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W., Shi, Y., Fan, R."Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury". Molecular Medicine Reports 14, no. 4 (2016): 3690-3696. https://doi.org/10.3892/mmr.2016.5720