Alleviative effect of grape seed proanthocyanidin extract on small artery vascular remodeling in spontaneous hypertensive rats via inhibition of collagen hyperplasia

  • Authors:
    • Ying Liang
    • Haiqing Gao
    • Jian Wang
    • Quanzhen Wang
    • Shaohua Zhao
    • Jun Zhang
    • Jie Qiu
  • View Affiliations

  • Published online on: March 7, 2017     https://doi.org/10.3892/mmr.2017.6292
  • Pages: 2643-2652
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Abstract

Vascular remodeling is a primary contributor to the initiation and development of hypertension, which has a pathological association with subsequent multi-organ damage. Grape seed proanthocyanidin extracts (GSPE) exhibit protective cardiovascular effects, resulting from their anti‑oxidant and anti‑inflammatory properties. However, the function and mechanism underlying the effect of GSPE on small artery remodeling remain to be elucidated. The present study investigated the effect of GSPE on vascular remodeling in the mesenteric small arteries of spontaneous hypertensive rats (SHR). Parameters associated with hypertension, including systolic blood pressure, oxidative stress, morphological and ultrastructural alteration of vessels, deposition of collagen and transforming growth factor (TGF)-β1, were analyzed. The results revealed that GSPE alleviated hypertension-induced hypertrophic vascular remodeling in the small arteries of SHR, which was independent of blood pressure. GSPE decreased oxidative stress associated with hypertension in SHR and suppressed the increased expression of TGF‑β1, which blocked the translocation and differentiation of adventitia fibroblasts and eventually inhibited collagen hyperplasia in the blood vessel. The inhibitory effect of GSPE on small artery remodeling was achieved via its suppressive effect on oxidant production and the subsequent intercellular and intracellular cascades. The findings of the present study supported the potential therapeutic value of GSPE for the treatment of hypertension.
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May-2017
Volume 15 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Liang Y, Gao H, Wang J, Wang Q, Zhao S, Zhang J and Qiu J: Alleviative effect of grape seed proanthocyanidin extract on small artery vascular remodeling in spontaneous hypertensive rats via inhibition of collagen hyperplasia. Mol Med Rep 15: 2643-2652, 2017
APA
Liang, Y., Gao, H., Wang, J., Wang, Q., Zhao, S., Zhang, J., & Qiu, J. (2017). Alleviative effect of grape seed proanthocyanidin extract on small artery vascular remodeling in spontaneous hypertensive rats via inhibition of collagen hyperplasia. Molecular Medicine Reports, 15, 2643-2652. https://doi.org/10.3892/mmr.2017.6292
MLA
Liang, Y., Gao, H., Wang, J., Wang, Q., Zhao, S., Zhang, J., Qiu, J."Alleviative effect of grape seed proanthocyanidin extract on small artery vascular remodeling in spontaneous hypertensive rats via inhibition of collagen hyperplasia". Molecular Medicine Reports 15.5 (2017): 2643-2652.
Chicago
Liang, Y., Gao, H., Wang, J., Wang, Q., Zhao, S., Zhang, J., Qiu, J."Alleviative effect of grape seed proanthocyanidin extract on small artery vascular remodeling in spontaneous hypertensive rats via inhibition of collagen hyperplasia". Molecular Medicine Reports 15, no. 5 (2017): 2643-2652. https://doi.org/10.3892/mmr.2017.6292