Health risk assessment of environmental selenium: Emerging evidence and challenges (Review)
- Authors:
- Marco Vinceti
- Tommaso Filippini
- Silvia Cilloni
- Annalisa Bargellini
- Anna Valeria Vergoni
- Aristides Tsatsakis
- Margherita Ferrante
-
Affiliations: CREAGEN, Research Center of Environmental, Genetic and Nutritional Epidemiology, Section of Public Health, University of Modena and Reggio Emilia, Modena, Italy, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Department of Forensic Sciences and Toxicology, University of Crete, Heraklion, Crete, Greece, Department of Medical, Surgical Sciences and Advanced Technologies ‘G.F. Ingrassia’, University of Catania, Catania, Italy - Published online on: March 24, 2017 https://doi.org/10.3892/mmr.2017.6377
- Pages: 3323-3335
-
Copyright: © Vinceti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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|
Vinceti M, Dennert G, Crespi CM, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R and Del Giovane C: Selenium for preventing cancer. Cochrane Database Syst Rev. 3:CD0051952014. | |
|
Lance P, Alberts DS, Thompson PA, Fales L, Wang F, Jose San J, Jacobs ET, Goodman PJ, Darke AK, Yee M, et al: Colorectal adenomas in participants of the SELECT randomized trial of selenium and vitamin E for prostate cancer prevention. Cancer Prev Res (Phila). 10:45–54. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F, Bhattacharyya A, Hsu CH, Chow HH, Ahnen DJ, et al: Selenium supplementation for prevention of colorectal adenomas and risk of associated type 2 diabetes. J Natl Cancer Inst. 108:pii: djw152. 2016. View Article : Google Scholar | |
|
Institute of Medicine Food and Nutrition Board: Dietary references intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academy Press; Washington, DC: 2000 | |
|
Vinceti M, Crespi CM, Bonvicini F, Malagoli C, Ferrante M, Marmiroli S and Stranges S: The need for a reassessment of the safe upper limit of selenium in drinking water. Sci Total Environ. 443:633–642. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Rothman KJ, Greenland S and Lash TL: Modern Epidemiology. Lippincott Williams & Wilkins; Philadelphia: 2012, View Article : Google Scholar | |
|
Michalke B, Halbach S and Nischwitz V: JEM spotlight: Metal speciation related to neurotoxicity in humans. J Environ Monit. 11:939–954. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Gammelgaard B, Jackson MI and Gabel-Jensen C: Surveying selenium speciation from soil to cell--forms and transformations. Anal Bioanal Chem. 399:1743–1763. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Weekley CM and Harris HH: Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease. Chem Soc Rev. 42:8870–8894. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Solovyev N, Mandrioli J, Crespi CM, Bonvicini F, Arcolin E, Georgoulopoulou E and Michalke B: Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite. Neurotoxicology. 38:25–32. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Grill P, Malagoli C, Filippini T, Storani S, Malavolti M and Michalke B: Selenium speciation in human serum and its implications for epidemiologic research: A cross-sectional study. J Trace Elem Med Biol. 31:1–10. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Wei ET, Malagoli C, Bergomi M and Vivoli G: Adverse health effects of selenium in humans. Rev Environ Health. 16:233–251. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Mandrioli J, Borella P, Michalke B, Tsatsakis A and Finkelstein Y: Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies. Toxicol Lett. 230:295–303. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Crespi CM, Malagoli C, Del Giovane C and Krogh V: Friend or foe? The current epidemiologic evidence on selenium and human cancer risk. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 31:305–341. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Burlingame B, Fillippini T, Naska A, Bargellini A and Borella P: The epidemiology of selenium and human healthSelenium: Its Molecular Biology and Role in Human Health. Hatfield D, Schweizer U and Gladyshev VN: 4th. Springer Science Business Media; New York: pp. 365–376. 2016, View Article : Google Scholar | |
|
Joint FAO/WHO Expert Consultation on Human Vitamin and Mineral Requirements: Vitamin and mineral requirements in human nutrition. 2nd. World Health Organization and Food and Agriculture Organization of the United Nations; Geneva: 2004 | |
|
Keshan Disease Research Group of the Chinese Academy of Medical Sciences: Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. Chin Med J (Engl). 92:477–482. 1979.PubMed/NCBI | |
|
Keshan Disease Research Group of the Chinese Academy of Medical Sciences: Observations on effect of sodium selenite in prevention of Keshan disease. Chin Med J (Engl). 92:471–476. 1979.PubMed/NCBI | |
|
Wang T and Li Q: Interpretation of selenium deficiency and Keshan disease with causal inference of modern epidemiologyThe 5th International Selenium Seminar. Organizing Committee of the International Selenium Seminar; Moscow: pp. 34–35. 2015 | |
|
Lei C, Niu X, Ma X and Wei J: Is selenium deficiency really the cause of Keshan disease? Environ Geochem Health. 33:183–188. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Winther KH, Bonnema SJ, Cold F, Debrabant B, Nybo M, Cold S and Hegedüs L: Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. Eur J Endocrinol. 172:657–667. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, Cappuccio FP, Ceriello A and Reid ME: Effects of long-term selenium supplementation on the incidence of type 2 diabetes: A randomized trial. Ann Intern Med. 147:217–223. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, et al: Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 301:39–51. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Rovesti S, Gabrielli C, Marchesi C, Bergomi M, Martini M and Vivoli G: Cancer mortality in a residential cohort exposed to environmental selenium through drinking water. J Clin Epidemiol. 48:1091–1097. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Rothman KJ, Bergomi M, Borciani N, Serra L and Vivoli G: Excess melanoma incidence in a cohort exposed to high levels of environmental selenium. Cancer Epidemiol Biomarkers Prev. 7:853–856. 1998.PubMed/NCBI | |
|
Vinceti M, Ballotari P, Steinmaus C, Malagoli C, Luberto F, Malavolti M and Rossi Giorgi P: Long-term mortality patterns in a residential cohort exposed to inorganic selenium in drinking water. Environ Res. 150:348–356. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Saint-Amour D, Roy MS, Bastien C, Ayotte P, Dewailly E, Després C, Gingras S and Muckle G: Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet. Neurotoxicology. 27:567–578. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Bonvicini F, Rothman KJ, Vescovi L and Wang F: The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: A population-based case-control study. Environ Health. 9:772010. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M and Rothman KJ: More results but no clear conclusion on selenium and cancer. Am J Clin Nutr. 104:245–246. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Hughes DJ, Duarte-Salles T, Hybsier S, Trichopoulou A, Stepien M, Aleksandrova K, Overvad K, Tjønneland A, Olsen A, Affret A, et al: Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 104:406–414. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ma X, Yang Y, Li HL, Zheng W, Gao J, Zhang W, Yang G, Shu XO and Xiang YB: Dietary trace element intake and liver cancer risk: Results from two population-based cohorts in China. Int J Cancer. 140:1050–1059. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Knekt P, Marniemi J, Teppo L, Heliövaara M and Aromaa A: Is low selenium status a risk factor for lung cancer? Am J Epidemiol. 148:975–982. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
van den Brandt PA, Goldbohm RA, van't Veer P, Bode P, Dorant E, Hermus RJ and Sturmans F: A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res. 53:4860–4865. 1993.PubMed/NCBI | |
|
Suadicani P, Hein HO and Gyntelberg F: Serum selenium level and risk of lung cancer mortality: A 16-year follow-up of the Copenhagen Male Study. Eur Respir J. 39:1443–1448. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA and Brookmeyer R: Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N Engl J Med. 315:1250–1254. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
van Noord PA, Maas MJ, van der Tweel I and Collette C: Selenium and the risk of postmenopausal breast cancer in the DOM cohort. Breast Cancer Res Treat. 25:11–19. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
van den Brandt PA, Goldbohm RA, van't Veer P, Bode P, Dorant E, Hermus RJ and Sturmans F: Toenail selenium levels and the risk of breast cancer. Am J Epidemiol. 140:20–26. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Garland M, Morris JS, Stampfer MJ, Colditz GA, Spate VL, Baskett CK, Rosner B, Speizer FE, Willett WC and Hunter DJ: Prospective study of toenail selenium levels and cancer among women. J Natl Cancer Inst. 87:497–505. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Clark LC, Combs GFJ Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, et al: Nutritional Prevention of Cancer Study Group: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. JAMA. 276:1957–1963. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Jablonska E and Vinceti M: Selenium and Human Health: Witnessing a Copernican Revolution? J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 33:328–368. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Higgins JP: A revised tool to assess risk of bias in randomized trials. (RoB 2.0). 2016. | |
|
Rees K, Hartley L, Day C, Flowers N, Clarke A and Stranges S: Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 1:CD0096712013. | |
|
Stratton MS, Reid ME, Schwartzberg G, Minter FE, Monroe BK, Alberts DS, Marshall JR and Ahmann FR: Selenium and prevention of prostate cancer in high-risk men: The Negative Biopsy Study. Anticancer Drugs. 14:589–594. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Algotar AM, Stratton MS, Ahmann FR, Ranger-Moore J, Nagle RB, Thompson PA, Slate E, Hsu CH, Dalkin BL, Sindhwani P, et al: Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer. Prostate. 73:328–335. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Karp DD, Lee SJ, Keller SM, Wright GS, Aisner S, Belinsky SA, Johnson DH, Johnston MR, Goodman G, Clamon G, et al: Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597. J Clin Oncol. 31:4179–4187. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kristal AR, Darke AK, Morris JS, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr, Goodman GE, Minasian LM, Parnes HL, et al: Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. J Natl Cancer Inst. 106:djt4562014. View Article : Google Scholar : PubMed/NCBI | |
|
Albanes D, Till C, Klein EA, Goodman PJ, Mondul AM, Weinstein SJ, Taylor PR, Parnes HL, Gaziano JM, Song X, et al: Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cancer Prev Res (Phila). 7:886–895. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Martinez EE, Darke AK, Tangen CM, Goodman PJ, Fowke JH, Klein EA and Abdulkadir SA: A functional variant in NKX3.1 associated with prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cancer Prev Res (Phila). 7:950–957. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs GF Jr, Park HK, Gross EG, Graham GF, Stratton MS, et al: Nutritional Prevention of Cancer Study Group: Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst. 95:1477–1481. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Dréno B, Euvrard S, Frances C, Moyse D and Nandeuil A: Effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients. Eur J Dermatol. 17:140–145. 2007.PubMed/NCBI | |
|
Lubinski J, Jaworska K, Durda K, Jakubowska A, Huzarski T, Byrski T, Stawicka M, Gronwald J, Górski B, Wasowicz W, et al: Selenium and the risk of cancer in BRCA1 carriers. Hered Cancer Clin Pract. 9:(Suppl 2). A52011. View Article : Google Scholar : | |
|
Duffield-Lillico AJ, Reid ME, Turnbull BW, Combs GFJ Jr, Slate EH, Fischbach LA, Marshall JR and Clark LC: Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: A summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev. 11:630–639. 2002.PubMed/NCBI | |
|
Duffield-Lillico AJ, Dalkin BL, Reid ME, Turnbull BW, Slate EH, Jacobs ET, Marshall JR and Clark LC: Nutritional Prevention of Cancer Study Group: Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: An analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int. 91:608–612. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Vinceti M, Maraldi T, Bergomi M and Malagoli C: Risk of chronic low-dose selenium overexposure in humans: Insights from epidemiology and biochemistry. Rev Environ Health. 24:231–248. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Yang GQ, Wang SZ, Zhou RH and Sun SZ: Endemic selenium intoxication of humans in China. Am J Clin Nutr. 37:872–881. 1983.PubMed/NCBI | |
|
Barron E, Migeot V, Rabouan S, Potin-Gautier M, Séby F, Hartemann P, Lévi Y and Legube B: The case for re-evaluating the upper limit value for selenium in drinking water in Europe. J Water Health. 7:630–641. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Frisbie SH, Mitchell EJ and Sarkar B: Urgent need to reevaluate the latest World Health Organization guidelines for toxic inorganic substances in drinking water. Environ Health. 14:632015. View Article : Google Scholar : PubMed/NCBI | |
|
Scientific Committee on Food: Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of SeleniumEuropean Commission. Brussels: 2000, https://ec.europa.eu/food/sites/food/files/safety/docs/sci-com_scf_out80g_en.pdf | |
|
Tsubota-Utsugi M, Imai E, Nakade M, Tsuboyama-Kasaoka N, Morita A and Tokudome S: Dietary Reference Intakes for Japanese - 2010. The summary report from the Scientific Committee of ‘Dietary Reference intakes for Japanese’National Institute of Health and Nutrition. Japan: 2012 | |
|
Nordic Nutrition Recommendations 2012. 5th. Nordic Council of Ministers; Copenhagen: 2014, doi: org/10.6027/Nord2014-002. | |
|
Società Italiana di Nutrizione Umana: LARN - Livelli di assunzione di riferimento di nutrienti e energia per la popolazione italiana - IV revisioneSICS. Milan: 2014, (In Italian). | |
|
Marschall TA, Bornhorst J, Kuehnelt D and Schwerdtle T: Differing cytotoxicity and bioavailability of selenite, methylselenocysteine, selenomethionine, selenosugar 1 and trimethylselenonium ion and their underlying metabolic transformations in human cells. Mol Nutr Food Res. 60:2622–2632. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Lazard M, Dauplais M, Blanquet S and Plateau P: Trans-sulfuration pathway seleno-amino acids are mediators of selenomethionine toxicity in Saccharomyces cerevisiae. J Biol Chem. 290:10741–10750. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Raine JC, Lallemand L, Pettem CM and Janz DM: Effects of chronic dietary selenomethionine exposure on the visual system of adult and F1 generation zebrafish (Danio rerio). Bull Environ Contam Toxicol. 97:331–336. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Dolgova NV, Hackett MJ, MacDonald TC, Nehzati S, James AK, Krone PH, George GN and Pickering IJ: Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms. Metallomics. 8:305–312. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Göen T, Schaller B, Jäger T, Bräu-Dümler Ch, Schaller KH and Drexler H: Biological monitoring of exposure and effects in workers employed in a selenium-processing plant. Int Arch Occup Environ Health. 88:623–630. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Jäger T, Drexler H and Göen T: Human metabolism and renal excretion of selenium compounds after oral ingestion of sodium selenate dependent on trimethylselenium ion (TMSe) status. Arch Toxicol. 90:149–158. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ito K, Mathes R, Ross Z, Nádas A, Thurston G and Matte T: Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City. Environ Health Perspect. 119:467–473. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Heck JE, Park AS, Qiu J, Cockburn M and Ritz B: Risk of leukemia in relation to exposure to ambient air toxics in pregnancy and early childhood. Int J Hyg Environ Health. 217:662–668. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Burk RF Jr: Selenium deficiency in search of a disease. Hepatology. 8:421–423. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Yu FF, Liu H and Guo X: Integrative multivariate logistic regression analysis of risk factors for Kashin-Beck disease. Biol Trace Elem Res. 174:274–279. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yu FF, Zhang YX, Zhang LH, Li WR, Guo X and Lammi MJ: Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease. Medicine (Baltimore). 95:e56692016. View Article : Google Scholar : PubMed/NCBI | |
|
Beck MA, Levander OA and Handy J: Selenium deficiency and viral infection. J Nutr. 133:(Suppl 1). 1463S–1467S. 2003.PubMed/NCBI | |
|
Sheridan PA, Zhong N, Carlson BA, Perella CM, Hatfield DL and Beck MA: Decreased selenoprotein expression alters the immune response during influenza virus infection in mice. J Nutr. 137:1466–1471. 2007.PubMed/NCBI | |
|
Gu BQ: Pathology of Keshan disease. A comprehensive review. Chin Med J (Engl). 96:251–261. 1983.PubMed/NCBI | |
|
Levander OA and Beck MA: Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. Biol Trace Elem Res. 56:5–21. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Xu GL, Wang SC, Gu BQ, Yang YX, Song HB, Xue WL, Liang WS and Zhang PY: Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. Biomed Environ Sci. 10:316–326. 1997.PubMed/NCBI | |
|
Chen J: An original discovery: Selenium deficiency and Keshan disease (an endemic heart disease). Asia Pac J Clin Nutr. 21:320–326. 2012.PubMed/NCBI | |
|
Guanqing H: On the etiology of Keshan disease: Two hypotheses. Chin Med J (Engl). 92:416–422. 1979.PubMed/NCBI | |
|
Cermelli C, Vinceti M, Scaltriti E, Bazzani E, Beretti F, Vivoli G and Portolani M: Selenite inhibition of Coxsackie virus B5 replication: Implications on the etiology of Keshan disease. J Trace Elem Med Biol. 16:41–46. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, et al: Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest. 120:4220–4235. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Scoto M, Cirak S, Mein R, Feng L, Manzur AY, Robb S, Childs AM, Quinlivan RM, Roper H, Jones DH, et al: SEPN1-related myopathies: Clinical course in a large cohort of patients. Neurology. 76:2073–2078. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Ardissone A, Bragato C, Blasevich F, Maccagnano E, Salerno F, Gandioli C, Morandi L, Mora M and Moroni I: SEPN1-related myopathy in three patients: Novel mutations and diagnostic clues. Eur J Pediatr. 175:1113–1118. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Schomburg L, Dumitrescu AM, Liao XH, Bin-Abbas B, Hoeflich J, Köhrle J and Refetoff S: Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. Thyroid. 19:277–281. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
EFSA NDA Panel: Scientific opinion on dietary reference values for selenium. EFSA J. 12:38462014. View Article : Google Scholar | |
|
Ge KY, Wang SQ, Bai J, Xue AN, Deng XJ, Su CQ and Wu SQ: The protective effect of selenium against viral myocarditis in miceSelenium in biology and medicine. Part B, Combs GF, Spallholz JE, Levander OA and Oldfield JE: Avi Book, Van Nostrand Reinhold Co.; New York: pp. 761–768. 1987 | |
|
Spallholz JE: Free radical generation by selenium compounds and their prooxidant toxicity. Biomed Environ Sci. 10:260–270. 1997.PubMed/NCBI | |
|
Stewart MS, Spallholz JE, Neldner KH and Pence BC: Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radic Biol Med. 26:42–48. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Letavayová L, Vlasáková D, Spallholz JE, Brozmanová J and Chovanec M: Toxicity and mutagenicity of selenium compounds in Saccharomyces cerevisiae. Mutat Res. 638:1–10. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Misra S, Boylan M, Selvam A, Spallholz JE and Björnstedt M: Redox-active selenium compounds - from toxicity and cell death to cancer treatment. Nutrients. 7:3536–3556. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Lee KH and Jeong D: Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review). Mol Med Rep. 5:299–304. 2012.PubMed/NCBI | |
|
Brozmanová J, Mániková D, Vlčková V and Chovanec M: Selenium: A double-edged sword for defense and offence in cancer. Arch Toxicol. 84:919–938. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Schiar VP, Dos Santos DB, Paixão MW, Nogueira CW, Rocha JB and Zeni G: Human erythrocyte hemolysis induced by selenium and tellurium compounds increased by GSH or glucose: A possible involvement of reactive oxygen species. Chem Biol Interact. 177:28–33. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Guo CH, Hsia S, Hsiung DY and Chen PC: Supplementation with selenium yeast on the prooxidant-antioxidant activities and anti-tumor effects in breast tumor xenograft-bearing mice. J Nutr Biochem. 26:1568–1579. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hafeman DG, Sunde RA and Hoekstra WG: Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr. 104:580–587. 1974.PubMed/NCBI | |
|
Oh SH, Sunde RA, Pope AL and Hoekstra WG: Glutathione peroxidase response to selenium intake in lambs fed a Torula yeast-based, artificial milk. J Anim Sci. 42:977–983. 1976. View Article : Google Scholar : PubMed/NCBI | |
|
Kramer GF and Ames BN: Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium. Mutat Res. 201:169–180. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Macallan DC and Sedgwick P: Selenium supplementation and selenoenzyme activity. Clin Sci (Lond). 99:579–581. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Tsongas TA and Ferguson SW: Selenium concentrations in human urine and drinking waterProceedings of ‘Trace Elements in Man and Animal-3’. Kirchgessner N: Institute for Nursing Physiology Technical University Munchen; Freising: pp. 320–321. 1978 | |
|
Tsongas TA and Ferguson SW: Human health effects of selenium in a rural Colorado drinking water supply. In: Proceedings of ‘Trace substances in environmental health-XIA symposium’. Hemphill DD: University of Missouri; Columbia: pp. 30–35. 1977 | |
|
Valentine JL: Environmental occurrence of selenium in waters and related health significance. Biomed Environ Sci. 10:292–299. 1997.PubMed/NCBI | |
|
Valentine JL, Kang HK, Dang PM and Schluchter M: Selenium concentrations and glutathione peroxidase activities in a population exposed to selenium via drinking water. J Toxicol Environ Health. 6:731–736. 1980. View Article : Google Scholar : PubMed/NCBI | |
|
Valentine JL, Faraji B and Kang HK: Human glutathione peroxidase activity in cases of high selenium exposures. Environ Res. 45:16–27. 1988. View Article : Google Scholar : PubMed/NCBI | |
|
Valentine JL, Reisbord LS, Kang HK and Schluchter M: Effects on human health of exposure to selenium in drinking waterProceedings of ‘Selenium in Biology and Medicine - Part B’. Combs GF, Levander OA, Spallholz JE and Oldfield JE: Van Nostrand Reihold Co.; New York: pp. 675–687. 1987 | |
|
Longnecker MP, Taylor PR, Levander OA, Howe M, Veillon C, McAdam PA, Patterson KY, Holden JM, Stampfer MJ, Morris JS, et al: Selenium in diet, blood, and toenails in relation to human health in a seleniferous area. Am J Clin Nutr. 53:1288–1294. 1991.PubMed/NCBI | |
|
Brätter P and de Negretti Brätter VE: Influence of high dietary selenium intake on the thyroid hormone level in human serum. J Trace Elem Med Biol. 10:163–166. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Fordyce FM, Zhan G, Green K and Liu X: Soil, grain and water chemistry in relation to human selenium-responsive diseases in Enshi District, China. Applied Geochemistry. 15:117–132. 2000.doi: 10.1016/S0883-2927(99)00035-9. View Article : Google Scholar | |
|
Zhu J, Wang N, Li S, Li L, Su H and Liu C: Distribution and transport of selenium in Yutangba, China: Impact of human activities. Sci Total Environ. 392:252–261. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Hira CK, Partal K and Dhillon KS: Dietary selenium intake by men and women in high and low selenium areas of Punjab. Public Health Nutr. 7:39–43. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Lemire M, Fillion M, Frenette B, Passos CJ, Guimarães JR, Barbosa F Jr and Mergler D: Selenium from dietary sources and motor functions in the Brazilian Amazon. Neurotoxicology. 32:944–953. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lemire M, Philibert A, Fillion M, Passos CJ, Guimarães JR, Barbosa F Jr and Mergler D: No evidence of selenosis from a selenium-rich diet in the Brazilian Amazon. Environ Int. 40:128–136. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Qin HB, Zhu JM, Liang L, Wang MS and Su H: The bioavailability of selenium and risk assessment for human selenium poisoning in high-Se areas, China. Environ Int. 52:66–74. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Martens IB, Cardoso BR, Hare DJ, Niedzwiecki MM, Lajolo FM, Martens A and Cozzolino SM: Selenium status in preschool children receiving a Brazil nut-enriched diet. Nutrition. 31:1339–1343. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chawla R, Loomba R, Chaudhary RJ, Singh S and Dhillon KS: Impact of high selenium exposure on organ function and biochemical profile of the rural population living in seleniferous soils in Punjab, IndiaGlobal advance in selenium research from theory to application. CRC Press; Sao Paulo: pp. 93–94. 2015, View Article : Google Scholar | |
|
Yu SY, Zhu YJ and Li WG: Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol Trace Elem Res. 56:117–124. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Yu SY, Zhu YJ, Li WG, Huang QS, Huang CZ, Zhang QN and Hou C: A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China. Biol Trace Elem Res. 29:289–294. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Li WG: Preliminary observations on effect of selenium yeast on high risk populations with primary liver cancer. Zhonghua Yu Fang Yi Xue Za Zhi. 26:268–271. 1992.(In Chinese). PubMed/NCBI | |
|
Li W, Zhu Y, Yan X, Zhang Q, Li X, Ni Z, Shen Z, Yao H and Zhu J: The prevention of primary liver cancer by selenium in high risk populations. Zhonghua Yu Fang Yi Xue Za Zhi. 34:336–338. 2000.(In Chinese). PubMed/NCBI | |
|
Lotan Y, Goodman PJ, Youssef RF, Svatek RS, Shariat SF, Tangen CM, Thompson IM Jr and Klein EA: Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT. J Urol. 187:2005–2010. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Klein EA, Thompson IM Jr, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, Minasian LM, Ford LG, Parnes HL, Gaziano JM, et al: Vitamin E and the risk of prostate cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 306:1549–1556. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Marshall JR, Tangen CM, Sakr WA, Wood DP Jr, Berry DL, Klein EA, Lippman SM, Parnes HL, Alberts DS, Jarrard DF, et al: Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917. Cancer Prev Res (Phila). 4:1761–1769. 2011. View Article : Google Scholar : PubMed/NCBI |
