Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters

Liu,Chungang; Wang,Juan; Xu,Shiqi; An,Shengshu; Tang,Siying; He,Jian; Liu,Yang; Lee,Robert  J.; Wang,Di

doi:10.3892/mmr.2017.6807

Paecilomyces tenuipes extract prevents depression-like behaviors in chronic unpredictable mild stress-induced rat model via modulation of neurotransmitters

Authors:
- Chungang Liu
- Juan Wang
- Shiqi Xu
- Shengshu An
- Siying Tang
- Jian He
- Yang Liu
- Robert J. Lee
- Di Wang
View Affiliations

Affiliations: School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China, Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, Liaoning 116023, P.R. China
Published online on: June 20, 2017 https://doi.org/10.3892/mmr.2017.6807
Pages: 2172-2178

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The medicinal fungus Paecilomyces tenuipes exhibits a variety of pharmacological effects, including antidepressive effects. The chronic unpredictable mild stress (CUMS)‑induced rat model has served an important role in studies involving antidepressants screening. The aim of the present study was to evaluate the antidepressant‑like activity of P. tenuipes N45 aqueous extract (PTNE) in a CUMS‑induced rat model of behavioral despair depression. Following 4 weeks of PTNE treatment, behavioral tests were conducted to investigate the antidepressant‑like activities, and the levels of neurotransmitters and hormones in blood and hypothalamus were measured. The results demonstrated that PTNE treatment significantly increased movement in the forced running test, whereas the immobility time was reduced in the hotplate test and the forced swim test in depression‑model rats. PTNE treatment was able to normalize the levels of hormones and neurotransmitters in serum and hypothalamus of CUMS rats. The data demonstrated that PTNE treatment may be a potential pharmaceutical agent in treatment‑resistant depression, and the effects of PTNE may be partly mediated through normalizing the levels of neurotransmitters.

View Figures

View References

1	Kessler RC: The costs of depression. Psychiat Clin N Am. 35:12012. View Article : Google Scholar
2	Mathers CD and Loncar D: Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 3:e4422006. View Article : Google Scholar : PubMed/NCBI
3	Luppa M, Heinrich S, Angermeyer MC, König HH and Riedel-Heller SG: Cost-of-illness studies of depression: A systematic review. J Affect Disord. 98:29–43. 2007. View Article : Google Scholar : PubMed/NCBI
4	Krishnan V and Nestler EJ: The molecular neurobiology of depression. Nature. 455:894–902. 2008. View Article : Google Scholar : PubMed/NCBI
5	Li X, Li L, Shen LL, Qian Y, Cao YX and Zhu DN: Changes of adrenomedullin and its receptor components mRNAs expression in the brain stem and hypothalamus-pituitary-adrenal axis of stress-induced hypertensive rats. Sheng Li Xue Bao. 56:723–729. 2004.PubMed/NCBI
6	Sartori SB, Whittle N, Hetzenauer A and Singewald N: Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment. Neuropharmacology. 62:304–312. 2012. View Article : Google Scholar : PubMed/NCBI
7	Zhou XJ, Liu M, Yan JJ, Cao Y and Liu P: Antidepressant-like effect of the extracted of Kai Xin San, a traditional Chinese herbal prescription, is explained by modulation of the central monoaminergic neurotransmitter system in mouse. J Ethnopharmacol. 139:422–428. 2012. View Article : Google Scholar : PubMed/NCBI
8	Ma Z, Ji W, Qu R, Wang M, Yang W, Zhan Z, Fu Q and Ma S: Metabonomic study on the antidepressant-like effects of banxia houpu decoction and its action mechanism. Evid Based Complement Alternat Med. 2013:2137392013. View Article : Google Scholar : PubMed/NCBI
9	Kang A, Hao H, Zheng X, Liang Y, Xie Y, Xie T, Dai C, Zhao Q, Wu X, Xie L and Wang G: Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. J Neuroinflammation. 8:1002011. View Article : Google Scholar : PubMed/NCBI
10	Cui M, Li Q, Zhang M, Zhao YJ, Huang F and Chen YJ: Long-term curcumin treatment antagonizes masseter muscle alterations induced by chronic unpredictable mild stress in rats. Arch Oral Biol. 59:258–267. 2014. View Article : Google Scholar : PubMed/NCBI
11	Thachil AF, Mohan R and Bhugra D: The evidence base of complementary and alternative therapies in depression. J Affect Disorders. 97:23–35. 2007. View Article : Google Scholar : PubMed/NCBI
12	Lee DH, Park T and Kim HW: Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 29:648–654. 2006. View Article : Google Scholar : PubMed/NCBI
13	Kan H, Ming L, Li C, Kan H, Sun B and Liang Y: Antidepressant effect of bioactive compounds from Paecilomyces tenuipes in mice and rats. Neural Regen Res. 5:1568–1572. 2010.
14	Yin YY, Ming L, Zheng LF, Kan HW, Li CR and Li WP: Bioactive compounds from Paecilomyces tenuipes regulating the function of the hypothalamo-hypophyseal system axis in chronic unpredictable stress rats. Chin Med J (Engl). 120:1088–1092. 2007.PubMed/NCBI
15	Jiang Y, Qi X, Gao K, Liu W, Li N, Cheng N, Ding G, Huang W, Wang Z and Xiao W: Relationship between molecular weight, monosaccharide composition and immunobiologic activity of Astragalus polysaccharides. Glycoconj J. 33:755–761. 2016. View Article : Google Scholar : PubMed/NCBI
16	Li SP, Yang FQ and Tsim KW: Quality control of Cordyceps sinensis, a valued traditional Chinese medicine. J Pharm Biomed Anal. 41:1571–1584. 2006. View Article : Google Scholar : PubMed/NCBI
17	Nakagawasai O, Yamada K, Nemoto W, Fukahori M, Tadano T and Tan-No K: Liver hydrolysate assists in the recovery from physical fatigue in a mouse model. J Pharmacol Sci. 123:328–335. 2013. View Article : Google Scholar : PubMed/NCBI
18	Espejo EF and Mir D: Structure of the rat's behaviour in the hot plate test. Behav Brain Res. 56:171–176. 1993. View Article : Google Scholar : PubMed/NCBI
19	Overstreet DH and Steiner M: Genetic and environmental models of stress-induced depression in rats. Stress Med. 14:261–268. 1998. View Article : Google Scholar
20	Ji WW, Li RP, Li M, Wang SY, Zhang X, Niu XX, Li W, Yan L, Wang Y, Fu Q and Ma SP: Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice. Chin J Nat Med. 12:753–759. 2014.PubMed/NCBI
21	Yan WJ, Tan YC, Xu JC, Tang XP, Zhang C, Zhang PB and Ren ZQ: Protective effects of silibinin and its possible mechanism of action in mice exposed to chronic unpredictable mild stress. Biomol Ther (Seoul). 23:245–250. 2015. View Article : Google Scholar : PubMed/NCBI
22	Bjørnebekk A, Mathé AA and Brené S: Running has differential effects on NPY, opiates, and cell proliferation in an animal model of depression and controls. Neuropsychopharmacology. 31:256–264. 2006. View Article : Google Scholar : PubMed/NCBI
23	Burke NN, Hayes E, Calpin P, Kerr DM, Moriarty O, Finn DP and Roche M: Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions. Neuroscience. 171:1300–1313. 2010. View Article : Google Scholar : PubMed/NCBI
24	Detke MJ, Rickels M and Lucki I: Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl). 121:66–72. 1995. View Article : Google Scholar : PubMed/NCBI
25	Steru L, Chermat R, Thierry B and Simon P: The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl). 85:367–370. 1985. View Article : Google Scholar : PubMed/NCBI
26	Mohammad-Zadeh LF, Moses L and Gwaltney-Brant SM: Serotonin: A review. J Vet Pharmacol Ther. 31:187–199. 2008. View Article : Google Scholar : PubMed/NCBI
27	Zhang ZJ, Wang D, Man SC, Ng R, McAlonan GM, Wong HK, Wong W, Lee J and Tan QR: Platelet 5-HT(1A) receptor correlates with major depressive disorder in drug-free patients. Prog Neuropsychopharmacol Biol Psychiatry. 53:74–79. 2014. View Article : Google Scholar : PubMed/NCBI
28	Gobbi G, Murphy DL, Lesch KP and Blier P: Modifications of the serotonergic system in mice lacking serotonin transporters: An in vivo electrophysiological study. J Pharmacol Exp Ther. 296:987–995. 2001.PubMed/NCBI
29	Chrousos GP: Stress and disorders of the stress system. Nat Rev Endocrinol. 5:374–381. 2009. View Article : Google Scholar : PubMed/NCBI
30	Lambert G, Johansson M, Agren H and Friberg P: Reduced brain norepinephrine and dopamine release in treatment-refractory depressive illness: Evidence in support of the catecholamine hypothesis of mood disorders. Arch Gen Psychiatry. 57:787–793. 2000. View Article : Google Scholar : PubMed/NCBI
31	Di Giovanni G, Strac D Svob, Sole M, Unzeta M, Tipton KF, Mück-Šeler D, Bolea I, Corte L Della, Perkovic M Nikolac, Pivac N, et al: Monoaminergic and histaminergic strategies and treatments in brain diseases. Front Neurosci. 10:5412016. View Article : Google Scholar : PubMed/NCBI
32	Ainsworth K, Smith SE, Zetterström TS, Pei Q, Franklin M and Sharp T: Effect of antidepressant drugs on dopamine D1 and D2 receptor expression and dopamine release in the nucleus accumbens of the rat. Psychopharmacology (Berl). 140:470–477. 1998. View Article : Google Scholar : PubMed/NCBI
33	Pirke KM: Central and peripheral noradrenalin regulation in eating disorders. Psychiat Res. 62:43–49. 1996. View Article : Google Scholar
34	Gareri P, Castagna A, Cotroneo AM, Putignano D, Conforti R, Santamaria F, Marino S and Putignano S: The Citicholinage Study: Citicoline plus cholinesterase inhibitors in aged patients affected with Alzheimer's disease study. J Alzheimers Dis. 56:557–565. 2017. View Article : Google Scholar : PubMed/NCBI
35	Brown RE, Stevens DR and Haas HL: The physiology of brain histamine. Prog Neurobiol. 63:637–672. 2001. View Article : Google Scholar : PubMed/NCBI
36	Geller HM, Springfield SA and Tiberio AR: Electrophysiological actions of histamine. Can J Physiol Pharmacol. 62:715–719. 1984. View Article : Google Scholar : PubMed/NCBI
37	Deuschle M, Bode L, Schnitzler P, Meyding-Lamadé U, Plesch A, Ludwig H, Hamann B and Heuser I: Hypothalamic-pituitary-adrenal (HPA) system activity in depression and infection with Borna disease virus and Chlamydia pneumoniae. Mol Psychiatry. 8:469–470. 2003. View Article : Google Scholar : PubMed/NCBI
38	Varghese FP and Brown ES: The hypothalamic-pituitary-adrenal axis in major depressive disorder: A brief primer for primary care physicians. Prim Care Companion J Clin Psychiatry. 3:151–155. 2001. View Article : Google Scholar : PubMed/NCBI
39	Mason BL and Pariante CM: The effects of antidepressants on the hypothalamic-pituitary-adrenal axis. Drug News Perspect. 19:603–608. 2006. View Article : Google Scholar : PubMed/NCBI
40	Bao L, Yao XS, Zhao L, Lu YQ and Kurihara H: Correlation between changes of central neurotransmitter expression and stress response in mice-A restraint time-course analysis. Neural Regeneration Res. 3:167–171. 2008.
41	Wu J, Du J, Xu C, Le J, Xu Y, Liu B and Dong J: Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. Pharmacol Biochem Behav. 98:273–278. 2011. View Article : Google Scholar : PubMed/NCBI
42	Song J, Xing G, Cao J and Teng L, Li C, Meng Q, Lu J, Zhou Y, Liu Y, Wang D and Teng L: Investigation of the antidepressant effects of exopolysaccharides obtained from Marasmius androsaceus fermentation in a mouse model. Mol Med Rep. 13:939–946. 2016.PubMed/NCBI