Syringic acid inhibits apoptosis pathways via downregulation of p38MAPK and JNK signaling pathways in H9c2 cardiomyocytes following hypoxia/reoxygenation injury

  • Authors:
    • Shou‑Kun Ding
    • Li‑Xia Wang
    • Lei‑Sheng Guo
    • Ping Luo
    • Juan‑Juan Du
    • Zong‑Lei Zhao
    • Guang‑Gong Wang
  • View Affiliations

  • Published online on: June 22, 2017     https://doi.org/10.3892/mmr.2017.6845
  • Pages: 2290-2294
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Abstract

Syringic acid (SA), a naturally occur­ring O‑methy­lated trihydroxybenzoic acid monomer extracted from Dendrobium nobile Lindl., has been demonstrated to attenuate renal ischemia‑reperfusion (I/R) injury. However, the role of SA in myocardial I/R injury is unclear. The present study aimed to clarify the cardioprotective effect of SA in myocardial I/R injury in vitro and explore the potential molecular mechanisms. In the present study, it was revealed that pretreatment with SA increased the viability and inhibited oxidant stress in H9c2 cardiomyocytes that had suffered hypoxia/reoxygenation (H/R). SA also markedly downregulated B‑cell lymphoma 2 (Bcl‑2) expression and inhibited the expression of Bcl‑2‑like protein 4 (Bax) and cleaved caspase‑3 in H9c2 cardiomyocytes induced by H/R. In addition, SA significantly alleviated H/R-induced the phosphorylation of p38 mitogen‑activated protein kinase (p38MAPK) and c‑Jun N‑terminal kinase (JNK) in H9c2 cardiomyocytes. In conclusion, the present study demonstrated that SA inhibits the apoptosis of H9c2 cardiomyocytes following H/R injury via reduced activation of the p38MAPK and JNK signaling pathways. The results support the therapeutic usage of SA in the treatment of myocardial infarction.
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August-2017
Volume 16 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Ding SK, Wang LX, Guo LS, Luo P, Du JJ, Zhao ZL and Wang GG: Syringic acid inhibits apoptosis pathways via downregulation of p38MAPK and JNK signaling pathways in H9c2 cardiomyocytes following hypoxia/reoxygenation injury. Mol Med Rep 16: 2290-2294, 2017
APA
Ding, S., Wang, L., Guo, L., Luo, P., Du, J., Zhao, Z., & Wang, G. (2017). Syringic acid inhibits apoptosis pathways via downregulation of p38MAPK and JNK signaling pathways in H9c2 cardiomyocytes following hypoxia/reoxygenation injury. Molecular Medicine Reports, 16, 2290-2294. https://doi.org/10.3892/mmr.2017.6845
MLA
Ding, S., Wang, L., Guo, L., Luo, P., Du, J., Zhao, Z., Wang, G."Syringic acid inhibits apoptosis pathways via downregulation of p38MAPK and JNK signaling pathways in H9c2 cardiomyocytes following hypoxia/reoxygenation injury". Molecular Medicine Reports 16.2 (2017): 2290-2294.
Chicago
Ding, S., Wang, L., Guo, L., Luo, P., Du, J., Zhao, Z., Wang, G."Syringic acid inhibits apoptosis pathways via downregulation of p38MAPK and JNK signaling pathways in H9c2 cardiomyocytes following hypoxia/reoxygenation injury". Molecular Medicine Reports 16, no. 2 (2017): 2290-2294. https://doi.org/10.3892/mmr.2017.6845