Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review)

  • Authors:
    • Shiqi Lin
    • Huanglei Pan
    • Hongli Wu
    • Difeng Ren
    • Jun Lu
  • View Affiliations

  • Published online on: August 4, 2017     https://doi.org/10.3892/mmr.2017.7168
  • Pages: 4403-4412
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Abstract

The renin‑angiotensin system (RAS) serves a critical role in blood pressure regulation and prevention of cardiovascular diseases. Efforts to develop functional foods that enhance the RAS have focused on inhibition of angiotensin‑converting enzyme (ACE) activity in the ACE‑angiotensin II (Ang II)‑Ang II type 1 receptor axis. ACE2 and the Mas receptor are important components of this axis. ACE2 catalyzes Ang II into Ang‑(1‑7), which then binds to the G‑protein‑coupled receptor Mas. In addition, it induces nitric oxide release from endothelial cells and exerts antiproliferative, vasodilatory and antihypertensive effects. The present review examined recent findings regarding the physiological and biological roles of the ACE2‑Ang‑(1‑7)‑Mas axis in the cardiovascular system, discussed potential food‑derived ACE2‑activating agents, and highlighted initiatives, based on this axis, that aim to develop functional foods for the treatment of hypertension.

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October-2017
Volume 16 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lin S, Pan H, Wu H, Ren D and Lu J: Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review). Mol Med Rep 16: 4403-4412, 2017
APA
Lin, S., Pan, H., Wu, H., Ren, D., & Lu, J. (2017). Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review). Molecular Medicine Reports, 16, 4403-4412. https://doi.org/10.3892/mmr.2017.7168
MLA
Lin, S., Pan, H., Wu, H., Ren, D., Lu, J."Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review)". Molecular Medicine Reports 16.4 (2017): 4403-4412.
Chicago
Lin, S., Pan, H., Wu, H., Ren, D., Lu, J."Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review)". Molecular Medicine Reports 16, no. 4 (2017): 4403-4412. https://doi.org/10.3892/mmr.2017.7168