Open Access

Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism

  • Authors:
    • Wenzhen Ji
    • Yu Zhu
    • Pengcheng Kan
    • Ying Cai
    • Zhida Wang
    • Zijian Wu
    • Ping Yang
  • View Affiliations

  • Published online on: August 11, 2017     https://doi.org/10.3892/mmr.2017.7227
0

Abstract

Currently, cerebral infarction (CI) is the leading cause of disability and the second leading cause of mortality in China, seriously affecting patient quality of life. Ischemia (IS) is considered to be the early stage of CI. The present study aims to investigate the variation of intestinal microbial communities in patients with CI and IS using high throughput sequencing technology, and then analyze the results to identify a novel potential pathogenic mechanism of CI and IS. In total, 8 patients with CI, 2 patients with IS and 10 healthy volunteers as a control were selected. Throughput sequencing technology was used to analyze the character and microbial population of the gut. The abundance of Escherichia, Bacteroides, Megamonas, Parabacteroides, Akkermansia, Prevotella, Faecalibacterium, Dialister, Bifidobacterium and Ruminococcus was the significant difference in the intestinal microbial communities of the CI and IS patients compared with the healthy group. It was also observed that CI and IS were closely associated with internal glucose metabolism. The intestinal gut disturbance of CI patients may be one of the causes inducing CI by glucose metabolism and maybe considered as a potential method to predict the disease.

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Print ISSN: 1791-2997
Online ISSN:1791-3004

2016 Impact Factor: 1.692
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APA
Ji, W., Zhu, Y., Kan, P., Cai, Y., Wang, Z., Wu, Z., & Yang, P. (1899). Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism. Molecular Medicine Reports, 0, 0-0. https://doi.org/10.3892/mmr.2017.7227
MLA
Ji, W., Zhu, Y., Kan, P., Cai, Y., Wang, Z., Wu, Z., Yang, P."Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism". Molecular Medicine Reports 0.0 (1899): 0-0.
Chicago
Ji, W., Zhu, Y., Kan, P., Cai, Y., Wang, Z., Wu, Z., Yang, P."Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism". Molecular Medicine Reports 0, no. 0 (1899): 0-0. https://doi.org/10.3892/mmr.2017.7227