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Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF‑κB in animal models of acute pharyngitis

  • Authors:
    • Zhong‑Xin Zhou
    • Shao‑Feng Mou
    • Xiao‑Qin Chen
    • Li‑Li Gong
    • Wen‑Sheng Ge

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  • Published online on: November 2, 2017     https://doi.org/10.3892/mmr.2017.7933
  • Pages: 1269-1274
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Recent studies have demonstrated that resveratrol can reduce blood sugar, improve insulin resistance, regulate abnormalities in lipid metabolism, and lower the secretion and expression of inflammatory factors. The present study investigated the anti‑inflammatory effects of resveratrol in animal models of acute pharyngitis, and its possible mechanisms. Commercial ELISA kits were used to measure tumor necrosis factor‑α, interleukin (IL)‑6, macrophage inflammatory protein‑2, cyclooxygenase‑2 levels and caspase‑3/9 activity. Toll‑like receptor (TLR)‑4, myeloid differentiation primary response protein MyD88, phosphorylated (p)‑nuclear factor (NF)‑κB and p‑IκB were analyzed using western blotting. In a rabbit model of acute pharyngitis, it was demonstrated that resveratrol inhibited tumor necrosis factor‑α and interleukin‑6 serum levels, macrophage inflammatory protein‑2 and cyclooxygenase‑2 activity levels, reactive oxygen species production and caspase‑3/9 activity. Resveratrol suppressed NACHT, LRR and PYD domains‑containing protein 3 and caspase‑1 protein expression, and reduced IL‑1β and IL‑18 protein expression in animal models of acute pharyngitis. Additionally, resveratrol suppressed TLR4 and myeloid differentiation primary response protein 88 protein expression, and reduced p‑NF‑κB and increased p‑IκB protein expression in animal models of acute pharyngitis. In conclusion, these findings indicated that the anti‑inflammatory activity of resveratrol prevents acute pharyngitis‑induced inflammation by inhibiting NF‑κB in animal models. Therefore, these data suggested an important clinical application of resveratrol in preventing acute pharyngitis.
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January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
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Spandidos Publications style
Zhou ZX, Mou SF, Chen XQ, Gong LL and Ge WS: Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF‑κB in animal models of acute pharyngitis. Mol Med Rep 17: 1269-1274, 2018.
APA
Zhou, Z., Mou, S., Chen, X., Gong, L., & Ge, W. (2018). Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF‑κB in animal models of acute pharyngitis. Molecular Medicine Reports, 17, 1269-1274. https://doi.org/10.3892/mmr.2017.7933
MLA
Zhou, Z., Mou, S., Chen, X., Gong, L., Ge, W."Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF‑κB in animal models of acute pharyngitis". Molecular Medicine Reports 17.1 (2018): 1269-1274.
Chicago
Zhou, Z., Mou, S., Chen, X., Gong, L., Ge, W."Anti-inflammatory activity of resveratrol prevents inflammation by inhibiting NF‑κB in animal models of acute pharyngitis". Molecular Medicine Reports 17, no. 1 (2018): 1269-1274. https://doi.org/10.3892/mmr.2017.7933