TGF‑β signaling: A complex role in tumorigenesis (Review)

  • Authors:
    • Shuang Liu
    • Shuang Chen
    • Jun Zeng
  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/mmr.2017.7970
  • Pages: 699-704
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TGF‑β) ligands (TGF‑β1, 2 and 3) are secreted inflammatory cytokines, which are known to be involved in various aspects of tumor development through two transmembrane serine‑threonine kinase receptors, TGFβR1 and TGFβR2. TGF‑β promotes or inhibits tumorigenesis depending on the concurrent gene mutations and tissue microenvironment present through the small mothers against decapentaplegic (Smad) and non‑Smad pathways. This review aims to provide a comprehensive overview of the role of the TGF‑β pathway in tumor initiation and progression.
View Figures
View References

Related Articles

Journal Cover

January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu S, Chen S and Zeng J: TGF‑β signaling: A complex role in tumorigenesis (Review). Mol Med Rep 17: 699-704, 2018.
APA
Liu, S., Chen, S., & Zeng, J. (2018). TGF‑β signaling: A complex role in tumorigenesis (Review). Molecular Medicine Reports, 17, 699-704. https://doi.org/10.3892/mmr.2017.7970
MLA
Liu, S., Chen, S., Zeng, J."TGF‑β signaling: A complex role in tumorigenesis (Review)". Molecular Medicine Reports 17.1 (2018): 699-704.
Chicago
Liu, S., Chen, S., Zeng, J."TGF‑β signaling: A complex role in tumorigenesis (Review)". Molecular Medicine Reports 17, no. 1 (2018): 699-704. https://doi.org/10.3892/mmr.2017.7970