Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion

Retraction in: /10.3892/mmr.2018.9374

  • Authors:
    • Tao Fan
    • Guozhi Huang
    • Wen Wu
    • Rong Guo
    • Qing Zeng
  • View Affiliations

  • Published online on: November 6, 2017     https://doi.org/10.3892/mmr.2017.7984
  • Pages: 1326-1332
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to analyze whether extracorporeal shock‑wave therapy (ESWT) combined with bone marrow mesenchymal stem cell (BMMSC) transplantation improves bone repair in a rabbit bone nonunion model. ESWT combined with BMMSC effectively enhanced mechanical strength, fracture stiffness and histological scores, and increased alkaline phosphatase activity, and osteopontin, runt related transcription factor 2 and collagen type I α1 chain protein expression levels in a rabbit bone nonunion model. In addition, ESWT combined with BMMSC effectively enhanced insulin‑like growth factor 1 and vascular endothelial growth factor contents, promoted transforming growth factor‑β (TGF‑β) contents, and induced the growth factors, bone morphogenetic protein (BMP)‑2, BMP‑4 and purinergic receptor P2X7 (P2X7) protein expression in the rabbit bone nonunion model. Thus, the present study demonstrated that ESWT combined with BMMSC transplantation improves bone repair in a rabbit bone nonunion model via the BMPs and P2X7 signaling pathways.
View Figures
View References

Related Articles

Journal Cover

January-2018
Volume 17 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fan T, Huang G, Wu W, Guo R and Zeng Q: Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion Retraction in /10.3892/mmr.2018.9374. Mol Med Rep 17: 1326-1332, 2018.
APA
Fan, T., Huang, G., Wu, W., Guo, R., & Zeng, Q. (2018). Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion Retraction in /10.3892/mmr.2018.9374. Molecular Medicine Reports, 17, 1326-1332. https://doi.org/10.3892/mmr.2017.7984
MLA
Fan, T., Huang, G., Wu, W., Guo, R., Zeng, Q."Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion Retraction in /10.3892/mmr.2018.9374". Molecular Medicine Reports 17.1 (2018): 1326-1332.
Chicago
Fan, T., Huang, G., Wu, W., Guo, R., Zeng, Q."Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion Retraction in /10.3892/mmr.2018.9374". Molecular Medicine Reports 17, no. 1 (2018): 1326-1332. https://doi.org/10.3892/mmr.2017.7984