Retinal microvasculature alteration in central serous chorioretinopathy

Yu,Li; Shao,Yi; Chai,Yong; Ye,Lin‑Hong; Yang,Qi‑Chen; Ye,Lei; Yuan,Qing; Jiang,Nan; Yi,Jing‑Lin

doi:10.3892/mmr.2017.8126

Retinal microvasculature alteration in central serous chorioretinopathy

Authors:
- Li Yu
- Yi Shao
- Yong Chai
- Lin‑Hong Ye
- Qi‑Chen Yang
- Lei Ye
- Qing Yuan
- Nan Jiang
- Jing‑Lin Yi
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Affiliations: Department of Opthalmology, Affiliated Eye Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian 361102, P.R. China
Published online on: November 21, 2017 https://doi.org/10.3892/mmr.2017.8126
Pages: 2335-2340
Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the changes of retinal microvascular network in patients with central serous chorioretinopathy (CSCR). A total of fifteen patients (right eye) with CSCR and 15 normal controls (right eye) were recruited. We used optical coherence tomography angiography to scan 6x6 mm macular retinal blood flow images with the application of a series of customized image segmentation processing program software to obtain microvascular and macrovascular density, and compared the superficial microvascular (SMIR), superficial macrovascular ring (SMAR) and the superficial total microvascular (STMI) density between CSCR patients and control group. Using the annular partition (C1‑C6) and quadrant partition methods on the macular, we compared the retinal vessel density changes. We also performed ROC analysis of superficial retinal microvessel density in CSCR retina to investigate the relationship between the microvascular density, the foveal thickness and visual acuity. The density of STMI and SMIR decreased in macular area in the patients with CSCR compared to the normal controls (P<0.05), while the density of SMAR did not change significantly. We found no significant difference in the density of SMIR with the quadrant partition method, whereas the annular partition method showed significantly decreased SMIR density only in the C1 region in patients with CSCR (P<0.05), with no significant difference observed in C2‑C6 regions. The density of SMIR had the highest differentiation power in the CSCR group, whereas the density of SC1 ring had the lowest differentiation power by the annular method. The largest area under the ROC curves was 0.77. The correlation index of the SMIR density and visual acuity was ‑0.544, whereas macular thickness and visual acuity was ‑0.644 in the CSCR group. The density of STMI and SMIR were decreased in patients with CSCR, which might provide further understanding of the pathogenesis of CSCR.

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