FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain

Retraction in: /10.3892/mmr.2017.8356

  • Authors:
    • Han Yan
    • Anhua Wu
  • View Affiliations

  • Published online on: November 23, 2017     https://doi.org/10.3892/mmr.2017.8146
  • Pages: 2535-2542
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Abstract

In the present study, the role of Forkhead Box O1 (FOXO1) in glioblastoma (GBM) cell tumorigenesis was examined and the underlying mechanisms were investigated. Reverse transcription‑quantitative polymerase chain reaction and western blot analyses were used to analyze the expression of FOXO1 in GBM cell lines (LN18 and T98G) and tissues. Compared with the control groups, FOXO1 was significantly downregulated in the GBM tissues and GBM cell lines (P<0.05). The effects of the expression of FOXO1 on GBM cell proliferation and cell cycle were examined using flow cytometry. The overexpression of FOXO1 markedly inhibited LN18 and T98G cell proliferation and arrested cell cycle at the G0/G1 phase. In addition, FOXO1 facilitated cell senescence through regulation of the expression of sirtuin 1. Epithelial‑mesenchymal transition (EMT) is a complex process, which affects cell growth, invasion and metastasis. The results of the present study revealed that FOXO1 inhibited EMT and metastasis in GBM. These finding revealed a novel mechanism of FOXO1 in the suppression of tumorigenesis and metastasis of GBM cells and suggested that FOXO1 may be a potential therapeutic target for treating GBM.
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February-2018
Volume 17 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yan H and Yan H: FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain Retraction in /10.3892/mmr.2017.8356. Mol Med Rep 17: 2535-2542, 2018
APA
Yan, H., & Yan, H. (2018). FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain Retraction in /10.3892/mmr.2017.8356. Molecular Medicine Reports, 17, 2535-2542. https://doi.org/10.3892/mmr.2017.8146
MLA
Yan, H., Wu, A."FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain Retraction in /10.3892/mmr.2017.8356". Molecular Medicine Reports 17.2 (2018): 2535-2542.
Chicago
Yan, H., Wu, A."FOXO1 is crucial in glioblastoma cell tumorigenesis and regulates the expression of SIRT1 to suppress senescence in the brain Retraction in /10.3892/mmr.2017.8356". Molecular Medicine Reports 17, no. 2 (2018): 2535-2542. https://doi.org/10.3892/mmr.2017.8146