Open Access

Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation

  • Authors:
    • Agnese Gugliandolo
    • Sabrina Giacoppo
    • Marcello Ficicchia
    • Angelo Aliquò
    • Placido Bramanti
    • Emanuela Mazzon
  • View Affiliations

  • Published online on: March 7, 2018     https://doi.org/10.3892/mmr.2018.8695
  • Pages: 6235-6244
  • Copyright: © Gugliandolo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

Certain nutrients are able to exert health promoting effects. The consumption of Brassicaceae vegetables has increased given their reported beneficial effects on human health, due to their high content of nutraceutical compounds. The health benefits appear to be associated with the presence of glucosinolates and flavonoids. Certain nutraceutics have been revealed to have anti‑inflammatory action. In the present study, the anti‑inflammatory properties of Eruca sativa seed extract (ESE) were evaluated in NSC‑34 motor neurons exposed to the cell culture medium of lipopolysaccharide (LPS)‑stimulated RAW 264.7 macrophages. Treatment with LPS‑stimulated RAW 264.7 medium induced apoptosis and the expression of Toll‑like receptor 4 (TLR4) and cyclooxygenase 2 (COX2) in NSC‑34 motor neurons. Additionally, the stimulation of NSC‑34 motor neurons with the medium of LPS‑treated macrophages triggered the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome proteins and the production of pro‑inflammatory cytokines. Pre‑treatment with ESE counteracted the apoptosis and production of pro‑inflammatory cytokines in NSC‑34 motor neurons treated with the medium of LPS‑treated RAW 264.7. It also eliminated COX2 and TLR4/NLRP3 inflammasome expression. In addition, pre‑treatment with ESE was able to restore interleukin 10 expression in NSC‑34 cells. These results demonstrate the anti‑inflammatory and neuroprotective effects of ESE.
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May-2018
Volume 17 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Gugliandolo A, Giacoppo S, Ficicchia M, Aliquò A, Bramanti P and Mazzon E: Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation. Mol Med Rep 17: 6235-6244, 2018.
APA
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., & Mazzon, E. (2018). Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation. Molecular Medicine Reports, 17, 6235-6244. https://doi.org/10.3892/mmr.2018.8695
MLA
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., Mazzon, E."Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation". Molecular Medicine Reports 17.5 (2018): 6235-6244.
Chicago
Gugliandolo, A., Giacoppo, S., Ficicchia, M., Aliquò, A., Bramanti, P., Mazzon, E."Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation". Molecular Medicine Reports 17, no. 5 (2018): 6235-6244. https://doi.org/10.3892/mmr.2018.8695