Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review)

  • Authors:
    • Xiang‑Hua Yu
    • Xiao‑Hua Ren
    • Xin‑Hua Liang
    • Ya‑Ling Tang
  • View Affiliations

  • Published online on: October 23, 2018     https://doi.org/10.3892/mmr.2018.9577
  • Pages: 5307-5316
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Abstract

Fatty acid (FA) metabolism, including the uptake, de novo synthesis and oxidation of FAs, is critical for the survival, proliferation, differentiation and metastasis of cancer cells. Several bodies of evidence have confirmed the metabolic reprogramming of FAs that occurs during cancer development. The present review aimed to evaluate FAs in terms of how the hallmarks of cancer are gradually established in tumourigenesis and tumour progression, and consider the auxo‑action and exact mechanisms of FA metabolism in these processes. In addition, this interaction in the tumour microenvironment was also discussed. Based on the role of FA metabolism in tumour development, targeting FA metabolism may effectively target cancer, affecting a number of important characteristics of cancer progression and survival.
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December-2018
Volume 18 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yu XH, Ren XH, Liang XH and Tang YL: Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review). Mol Med Rep 18: 5307-5316, 2018.
APA
Yu, X., Ren, X., Liang, X., & Tang, Y. (2018). Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review). Molecular Medicine Reports, 18, 5307-5316. https://doi.org/10.3892/mmr.2018.9577
MLA
Yu, X., Ren, X., Liang, X., Tang, Y."Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review)". Molecular Medicine Reports 18.6 (2018): 5307-5316.
Chicago
Yu, X., Ren, X., Liang, X., Tang, Y."Roles of fatty acid metabolism in tumourigenesis: Beyond providing nutrition (Review)". Molecular Medicine Reports 18, no. 6 (2018): 5307-5316. https://doi.org/10.3892/mmr.2018.9577