Overlapping of irritable bowel syndrome with erosive esophagitis and the performance of Rome criteria in diagnosing IBS in a clinical setting
- Authors:
- Magdy El‑Salhy
- Odd Helge Gilja
- Jan Gunnar Hatlebakk
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Affiliations: Section for Gastroenterology, Department of Medicine, Stord Hospital, 5416 Stord, Norway, Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway - Published online on: May 23, 2019 https://doi.org/10.3892/mmr.2019.10284
- Pages: 787-794
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Copyright: © El‑Salhy et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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El-Salhy M: Irritable bowel syndrome: Diagnosis and pathogenesis. World J Gastroenterol. 18:5151–5163. 2012.PubMed/NCBI | |
|
El-Salhy M: Recent developments in the pathophysiology of irritable bowel syndrome. World J Gastroenterol. 21:7621–7636. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Hatlebakk JG, Gilja OH and Hausken T: Irritable bowel syndrome: Recent developments in diagnosis, pathophysiology, and treatment. Expert Rev Gastroenterol Hepatol. 8:435–443. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M: Recent advances in the diagnosis of irritable bowel syndrome. Expert Rev Gastroenterol Hepatol. 9:1161–1174. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Locke GR III, Talley NJ, Fett SL, Zinsmeister AR and Melton LJ III: Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, Minnesota. Gastroenterology. 112:1448–1456. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Canavan C, West J and Card T: The epidemiology of irritable bowel syndrome. Clin Epidemiol. 6:71–80. 2014.PubMed/NCBI | |
|
Nam SY, Ryu KH and Park BJ: Irritable bowel syndrome is associated with gastroesophageal reflux symptom but not erosive esophagitis. J Neurogastroenterol Motil. 19:521–531. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Smart HL, Nicholson DA and Atkinson M: Gastro-oesophageal reflux in the irritable bowel syndrome. Gut. 27:1127–1131. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
Lee SY, Lee KJ, Kim SJ and Cho SW: Prevalence and risk factors for overlaps between gastroesophageal reflux disease, dyspepsia, and irritable bowel syndrome: A population-based study. Digestion. 79:196–201. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Jung HK, Halder S, McNally M, Locke GR III, Schleck CD, Zinsmeister AR and Talley NJ; Overlap of gastro-oesophageal reflux disease, irritable bowel syndrome, : Prevalence and risk factors in the general population. Aliment Pharmacol Ther. 26:453–461. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Talley NJ: Overlapping abdominal symptoms: Why do GERD and IBS often coexist? Drugs Today (Barc). 42 (Suppl B):S3–S8. 2006. | |
|
Lembo A, Zaman M, Jones M and Talley NJ: Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: A twin study. Aliment Pharmacol Ther. 25:1343–1350. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Cheung TK, Lam KF, Hu WH, Lam CL, Wong WM, Hui WM, Lai KC, Lam SK and Wong BC: Positive association between gastro-oesophageal reflux disease and irritable bowel syndrome in a Chinese population. Aliment Pharmacol Ther. 25:1099–1104. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wu JC, Cheung CM, Wong VW and Sung JJ: Distinct clinical characteristics between patients with nonerosive reflux disease and those with reflux esophagitis. Clin Gastroenterol Hepatol. 5:690–695. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Lovell RM and Ford AC: Global prevalence of and risk factors for irritable bowel syndrome: A meta-analysis. Clin Gastroenterol Hepatol. 10:712–721 e4. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Noh YW, Jung HK, Kim SE and Jung SA: Overlap of erosive and non-erosive Reflux diseases with functional gastrointestinal disorders according to Rome III criteria. J Neurogastroenterol Motil. 16:148–156. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lovell RM and Ford AC: Prevalence of gastro-esophageal reflux-type symptoms in individuals with irritable bowel syndrome in the community: A meta-analysis. Am J Gastroenterol. 107:1793–1802. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Y, Zou D, Wang R, Ma X, Yan X, Man X, Gao L, Fang J, Yan H, Kang X, et al: Dyspepsia and irritable bowel syndrome in China: A population-based endoscopy study of prevalence and impact. Aliment Pharmacol Ther. 32:562–572. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Neumann H, Monkemuller K, Kandulski A and Malfertheiner P: Dyspepsia and IBS symptoms in patients with NERD, ERD and Barrett's esophagus. Dig Dis. 26:243–247. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Schmulson MJ and Drossman DA: What is new in Rome IV. J Neurogastroenterol Motil. 23:151–163. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Manning AP, Thompson WG, Heaton KW and Morris AF: Towards positive diagnosis of the irritable bowel. Br Med J. 2:653–654. 1978. View Article : Google Scholar : PubMed/NCBI | |
|
Jellema P, van der Windt DA, Schellevis FG and van der Horst HE: Systematic review: Accuracy of symptom-based criteria for diagnosis of irritable bowel syndrome in primary care. Aliment Pharmacol Ther. 30:695–706. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ford AC, Talley NJ, Veldhuyzen van Zanten SJ, Vakil NB, Simel DL and Moayyedi P: Will the history and physical examination help establish that irritable bowel syndrome is causing this patient's lower gastrointestinal tract symptoms? JAMA. 300:1793–1805. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Drossman DA: The functional gastrointestinal disorders and the Rome II process. Gut. 45 (Suppl 2):II1–II5. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Lin OS: Colonoscopy in irritable bowel syndrome: Whom are we reassuring? Gastrointest Endosc. 62:900–902. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F and Spiller RC: Functional bowel disorders. Gastroenterology. 130:1480–1491. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Whitehead WE, Palsson OS and Simrén M: Irritable bowel syndrome: What do the new Rome IV diagnostic guidelines mean for patient management? Expert Rev Gastroenterol Hepatol. 11:281–283. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Pardi DS, Smyrk TC, Tremaine WJ and Sandborn WJ: Microscopic colitis: A review. Am J Gastroenterol. 97:794–802. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Sood R, Camilleri M, Gracie DJ, Gold MJ, To N, Law GR and Ford AC: Enhancing diagnostic performance of symptom-based criteria for irritable bowel syndrome by additional history and limited diagnostic evaluation. Am J Gastroenterol. 111:1446–1454. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Armstrong D, Bennett JR, Blum AL, Dent J, De Dombal FT, Galmiche JP, Lundell L, Margulies M, Richter JE, Spechler SJ, et al: The endoscopic assessment of esophagitis: A progress report on observer agreement. Gastroenterology. 111:85–92. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, et al: Endoscopic assessment of oesophagitis: Clinical and functional correlates and further validation of the Los Angeles classification. Gut. 45:172–180. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Takashima T, Iwakiri R, Sakata Y, Yamaguchi D, Tsuruoka N, Akutagawa K, Komatsu-Tanaka M, Higuchi T, Tanaka Y, Shimoda R, et al: Endoscopic reflux esophagitis and Helicobacter pylori infection in young healthy Japanese volunteers. Digestion. 86:55–58. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Gyawali CP, Kahrilas PJ, Savarino E, Zerbib F, Mion F, Smout AJPM, Vaezi M, Sifrim D, Fox MR, Vela MF, et al: Modern diagnosis of GERD: The Lyon Consensus. Gut. 67:1351–1362. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Gwee KA, Lu CL and Ghoshal UC: Epidemiology of irritable bowel syndrome in Asia: Something old, something new, something borrowed. J Gastroenterol Hepatol. 24:1601–1607. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Hoseini-Asl MK and Amra B: Prevalence of irritable bowel syndrome in Shahrekord, Iran. Indian J Gastroenterol. 22:215–216. 2003.PubMed/NCBI | |
|
Shah SS, Bhatia SJ and Mistry FP: Epidemiology of dyspepsia in the general population in Mumbai. Indian J Gastroenterol. 20:103–106. 2001.PubMed/NCBI | |
|
Ghoshal UC, Abraham P, Bhatt C, Choudhuri G, Bhatia SJ, Shenoy KT, Banka NH, Bose K, Bohidar NP, Chakravartty K, et al: Epidemiological and clinical profile of irritable bowel syndrome in India: Report of the Indian Society of Gastroenterology Task Force. Indian J Gastroenterol. 27:22–28. 2008.PubMed/NCBI | |
|
Han SH, Lee OY, Bae SC, Lee SH, Chang YK, Yang SY, Yoon BC, Choi HS, Hahm JS, Lee MH, et al: Prevalence of irritable bowel syndrome in Korea: Population-based survey using the Rome II criteria. J Gastroenterol Hepatol. 21:1687–1692. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Kwan AC, Hu WH, Chan YK, Yeung YW, Lai TS and Yuen H: Prevalence of irritable bowel syndrome in Hong Kong. J Gastroenterol Hepatol. 17:1180–1186. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Husain N, Chaudhry IB, Jafri F, Niaz SK, Tomenson B and Creed F: A population-based study of irritable bowel syndrome in a non-Western population. Neurogastroenterol Motil. 20:1022–1029. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong LS, Chen MH, Chen HX, Xu AG, Wang WA and Hu PJ: A population-based epidemiologic study of irritable bowel syndrome in South China: Stratified randomized study by cluster sampling. Aliment Pharmacol Ther. 19:1217–1224. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Chang FY, Lu CL and Chen TS: The current prevalence of irritable bowel syndrome in Asia. J Neurogastroenterol Motil. 16:389–400. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Karaman N, Türkay C and Yönem O: Irritable bowel syndrome prevalence in city center of Sivas. Turk J Gastroenterol. 14:128–131. 2003.PubMed/NCBI | |
|
Celebi S, Acik Y, Deveci SE, Bahcecioglu IH, Ayar A, Demir A and Durukan P: Epidemiological features of irritable bowel syndrome in a Turkish urban society. J Gastroenterol Hepatol. 19:738–743. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Masud MA, Hasan M and Khan AK: Irritable bowel syndrome in a rural community in Bangladesh: Prevalence, symptoms pattern, and health care seeking behavior. Am J Gastroenterol. 96:1547–1552. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Quigley EM, Locke GR, Mueller-Lissner S, Paulo LG, Tytgat GN, Helfrich I and Schaefer E: Prevalence and management of abdominal cramping and pain: A multinational survey. Aliment Pharmacol Ther. 24:411–419. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Vandvik PO, Lydersen S and Farup PG: Prevalence, comorbidity and impact of irritable bowel syndrome in Norway. Scand J Gastroenterol. 41:650–656. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E, et al: U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci. 38:1569–1580. 1993. View Article : Google Scholar : PubMed/NCBI | |
|
Saito YA, Schoenfeld P and Locke GR III: The epidemiology of irritable bowel syndrome in North America: A systematic review. Am J Gastroenterol. 97:1910–1915. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Boekema PJ, van Dam van Isselt EF, Bots ML and Smout AJ: Functional bowel symptoms in a general Dutch population and associations with common stimulants. Neth J Med. 59:23–30. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Agréus L, Svärdsudd K, Nyrén O and Tibblin G: Irritable bowel syndrome and dyspepsia in the general population: Overlap and lack of stability over time. Gastroenterology. 109:671–680. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Hillilä MT and Färkkilä MA: Prevalence of irritable bowel syndrome according to different diagnostic criteria in a non-selected adult population. Aliment Pharmacol Ther. 20:339–345. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Kay L, Jørgensen T and Jensen KH: The epidemiology of irritable bowel syndrome in a random population: Prevalence, incidence, natural history and risk factors. J Intern Med. 236:23–30. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Thompson WG, Irvine EJ, Pare P, Ferrazzi S and Rance L: Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire. Dig Dis Sci. 47:225–235. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Boyce PM, Koloski NA and Talley NJ: Irritable bowel syndrome according to varying diagnostic criteria: Are the new Rome II criteria unnecessarily restrictive for research and practice? Am J Gastroenterol. 95:3176–3183. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Mearin F, Badia X, Balboa A, Baró E, Caldwell E, Cucala M, Díaz-Rubio M, Fueyo A, Ponce J and Roset M: Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: Comparison of Rome II versus previous criteria in a general population. Scand J Gastroenterol. 36:1155–1161. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Patcharatrakul T, Hatlebakk JG, Hausken T, Gilja OH and Gonlachanvit S: Chromogranin A cell density in the large intestine of Asian and European patients with irritable bowel syndrome. Scand J Gastroenterol. 52:691–697. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Patcharatrakul T, Hatlebakk JG, Hausken T, Gilja OH and Gonlachanvit S: Enteroendocrine, Musashi 1 and neurogenin 3 cells in the large intestine of Thai and Norwegian patients with irritable bowel syndrome. Scand J Gastroenterol. 52:1331–1339. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Whitehead WE and Drossman DA: Validation of symptom-based diagnostic criteria for irritable bowel syndrome: A critical review. Am J Gastroenterol. 105:814–820; quiz 813, 821. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Moayyedi P and Ford AC: Symptom-based diagnostic criteria for irritable bowel syndrome: The more things change, the more they stay the same. Gastroenterol Clin North Am. 40:87–103. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Palsson OS, Whitehead WE, van Tilburg MA, Chang L, Chey W, Crowell MD, Keefer L, Lembo AJ, Parkman HP, Rao SS, et al: Rome IV diagnostic questionnaires and tables for investigators and clinicians. Gastroenterology. Feb 13–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI | |
|
Sood R, Gracie DJ, Gold MJ, To N, Pinto-Sanchez MI, Bercik P, Moayyedi P, Ford AC and Law GR; Derivation and validation of a diagnostic test for irritable bowel syndrome using latent class analysis, : Aliment Pharmacol Ther. 45:824–832. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Kruis W, Thieme C, Weinzierl M, Schüssler P, Holl J and Paulus W: A diagnostic score for the irritable bowel syndrome. Its value in the exclusion of organic disease. Gastroenterology. 87:1–7. 1984. View Article : Google Scholar : PubMed/NCBI | |
|
Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, Elitsur Y, Green PH, Guandalini S, Hill ID, et al: Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: A large multicenter study. Arch Intern Med. 163:286–292. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
van der Wouden EJ, Nelis GF and Vecht J: Screening for coeliac disease in patients fulfilling the Rome II criteria for irritable bowel syndrome in a secondary care hospital in The Netherlands: A prospective observational study. Gut. 56:444–445. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Locke GR III, Murray JA, Zinsmeister AR, Melton LJ III and Talley NJ: Celiac disease serology in irritable bowel syndrome and dyspepsia: a population-based case-control study. Mayo Clin Proc. 79:476–482. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hin H, Bird G, Fisher P, Mahy N and Jewell D: Coeliac disease in primary care: Case finding study. BMJ. 318:164–167. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Shahbazkhani B, Forootan M, Merat S, Akbari MR, Nasserimoghadam S, Vahedi H and Malekzadeh R: Coeliac disease presenting with symptoms of irritable bowel syndrome. Aliment Pharmacol Ther. 18:231–235. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Catassi C, Kryszak D, Louis-Jacques O, Duerksen DR, Hill I, Crowe SE, Brown AR, Procaccini NJ, Wonderly BA, Hartley P, et al: Detection of Celiac disease in primary care: A multicenter case-finding study in North America. Am J Gastroenterol. 102:1454–1460. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Sanders DS, Carter MJ, Hurlstone DP, Pearce A, Ward AM, McAlindon ME and Lobo AJ: Association of adult coeliac disease with irritable bowel syndrome: A case-control study in patients fulfilling Rome II criteria referred to secondary care. Lancet. 358:1504–1508. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Korkut E, Bektas M, Oztas E, Kurt M, Cetinkaya H and Ozden A: The prevalence of celiac disease in patients fulfilling Rome III criteria for irritable bowel syndrome. Eur J Intern Med. 21:389–392. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Sanders DS, Patel D, Stephenson TJ, Ward AM, McCloskey EV, Hadjivassiliou M and Lobo AJ: A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol. 15:407–413. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Lomholt-Beck B and Gundersen D: The prevalence of celiac disease in patients with irritable bowel syndrome. Mol Med Report. 4:403–405. 2011. | |
|
Aziz I and Sanders DS: The irritable bowel syndrome-celiac disease connection. Gastrointest Endosc Clin N Am. 22:623–637. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Cash BD, Rubenstein JH, Young PE, Gentry A, Nojkov B, Lee D, Andrews AH, Dobhan R and Chey WD: The prevalence of celiac disease among patients with nonconstipated irritable bowel syndrome is similar to controls. Gastroenterology. 141:1187–1193. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Isgar B, Harman M, Kaye MD and Whorwell PJ: Symptoms of irritable bowel syndrome in ulcerative colitis in remission. Gut. 24:190–192. 1983. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Gundersen D, Gilja OH, Hatlebakk JG and Hausken T: Is irritable bowel syndrome an organic disorder? World J Gastroenterol. 20:384–400. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ansari R, Attari F, Razjouyan H, Etemadi A, Amjadi H, Merat S and Malekzadeh R: Ulcerative colitis and irritable bowel syndrome: Relationships with quality of life. Eur J Gastroenterol Hepatol. 20:46–50. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Simrén M, Axelsson J, Gillberg R, Abrahamsson H, Svedlund J and Björnsson ES: Quality of life in inflammatory bowel disease in remission: The impact of IBS-like symptoms and associated psychological factors. Am J Gastroenterol. 97:389–396. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Keohane J, O'Mahony C, O'Mahony L, O'Mahony S, Quigley EM and Shanahan F: Irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease: A real association or reflection of occult inflammation? Am J Gastroenterol. 105:1788, 1789–1794; quiz 1795. 2010. View Article : Google Scholar | |
|
Minderhoud IM, Oldenburg B, Wismeijer JA, van Berge Henegouwen GP and Smout AJ: IBS-like symptoms in patients with inflammatory bowel disease in remission; relationships with quality of life and coping behavior. Dig Dis Sci. 49:469–474. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Halwe J, Lomholt-Beck B and Gundersen D: The prevalence of inflammatory bowel diseases, microscopic colitis, and colorectal cancer in patients with irritable bowel syndrome. Gastroenterol Insights. 3:e32011. View Article : Google Scholar | |
|
Tolliver BA, Herrera JL and DiPalma JA: Evaluation of patients who meet clinical criteria for irritable bowel syndrome. Am J Gastroenterol. 89:176–178. 1994.PubMed/NCBI | |
|
Spiller R, Aziz Q, Creed F, Emmanuel A, Houghton L, Hungin P, Jones R, Kumar D, Rubin G, Trudgill N, et al: Guidelines on the irritable bowel syndrome: Mechanisms and practical management. Gut. 56:1770–1798. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
El-Salhy M, Hatlebakk JG, Gilja OH and Hausken T: The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome. Nutr J. 14:922015. View Article : Google Scholar : PubMed/NCBI | |
|
Heizer WD, Southern S and McGovern S: The role of diet in symptoms of irritable bowel syndrome in adults: A narrative review. J Am Diet Assoc. 109:1204–1214. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
O'Sullivan MA, Mahmud N, Kelleher DP, Lovett E and O'Morain CA: Patient knowledge and educational needs in irritable bowel syndrome. Eur J Gastroenterol Hepatol. 12:39–43. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Stenner PH, Dancey CP and Watts S: The understanding of their illness amongst people with irritable bowel syndrome: A Q methodological study. Soc Sci Med. 51:439–452. 2000. View Article : Google Scholar : PubMed/NCBI |
