Methylation in the TP53 promoter is associated with ischemic stroke

  • Authors:
    • Yan Wei
    • Zhongzheng Sun
    • Yun Wang
    • Zhaohong Xie
    • Shunliang Xu
    • Yingying Xu
    • Xiaoyan Zhou
    • Jianzhong Bi
    • Zhengyu Zhu
  • View Affiliations

  • Published online on: June 5, 2019     https://doi.org/10.3892/mmr.2019.10348
  • Pages: 1404-1410
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Abstract

Cerebral ischemic stroke (IS) is a disease presenting high morbidity and mortality rates worldwide. Understanding of the pathogenesis underlying IS may facilitate the development of effective clinical therapeutic strategies and improve the prevention of this disease, decreasing its occurrence rate. Epigenetic alterations have recently attracted attention as possible mechanisms underlying IS. Additionally, tumor protein p53 (TP53) was identified to be involved in the pathophysiology of cerebral stroke. In the present study, the methylation status of the TP53 promoter was investigated in patients with IS and in age‑matched healthy controls. The methylation status of the promoter of TP53 was significantly increased in patients with IS compared with healthy subjects. Additionally, the methylation level of the TP53 promoter was identified to be associated with carotid intima‑media thickness, the degree of carotid atherosclerosis and the circulating levels of homocysteine in peripheral blood. The present findings may improve the understanding of the role of the epigenetic modifications of the TP53 promoter in IS pathogenesis.
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August-2019
Volume 20 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wei Y, Sun Z, Wang Y, Xie Z, Xu S, Xu Y, Zhou X, Bi J and Zhu Z: Methylation in the TP53 promoter is associated with ischemic stroke. Mol Med Rep 20: 1404-1410, 2019.
APA
Wei, Y., Sun, Z., Wang, Y., Xie, Z., Xu, S., Xu, Y. ... Zhu, Z. (2019). Methylation in the TP53 promoter is associated with ischemic stroke. Molecular Medicine Reports, 20, 1404-1410. https://doi.org/10.3892/mmr.2019.10348
MLA
Wei, Y., Sun, Z., Wang, Y., Xie, Z., Xu, S., Xu, Y., Zhou, X., Bi, J., Zhu, Z."Methylation in the TP53 promoter is associated with ischemic stroke". Molecular Medicine Reports 20.2 (2019): 1404-1410.
Chicago
Wei, Y., Sun, Z., Wang, Y., Xie, Z., Xu, S., Xu, Y., Zhou, X., Bi, J., Zhu, Z."Methylation in the TP53 promoter is associated with ischemic stroke". Molecular Medicine Reports 20, no. 2 (2019): 1404-1410. https://doi.org/10.3892/mmr.2019.10348