Open Access

E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1

  • Authors:
    • Xia Li
    • Naijin Zhang
    • Ying Zhang
    • Pengyu Jia
    • Yuxuan Guo
    • Yichen Tian
    • Shilong You
    • Shaojun Wu
    • Yingxian Sun
  • View Affiliations

  • Published online on: June 18, 2019     https://doi.org/10.3892/mmr.2019.10394
  • Pages: 1561-1568
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxidative stress participates in several heart diseases and is an important mechanism contributing to the pathological alterations of myocardial cell injury. In recent years, ubiquitylation has been demonstrated to be an important biochemical reaction associated with apoptosis. To investigate the effects and interactions of the E3 ligase F‑box and WD repeat domain containing 7 (Fbw7) and MCL1 apoptosis regulator, BCL2 family member (Mcl‑1) in myocardial cells during oxidative stress, Cell Counting Kit‑8, flow cytometry, western blot, reactive oxygen species and co‑immunoprecipitation assays were conducted. The current study revealed that Fbw7 may facilitate apoptosis via the Mcl‑1‑Bax pathway in oxidative stress‑induced myocardial H9c2 cell injury. Mcl‑1 inhibits the functions of Bcl‑2 family members, including the mitochondrial apoptosis factor Bax, to maintain cell viability; however, the present study suggested that Fbw7 may degrade Mcl‑1 and impaired this process. Therefore, it may be hypothesized that Fbw‑7 promotes myocardial cell injury via interacting with Mcl‑1.
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August-2019
Volume 20 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Li X, Zhang N, Zhang Y, Jia P, Guo Y, Tian Y, You S, Wu S and Sun Y: E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1. Mol Med Rep 20: 1561-1568, 2019.
APA
Li, X., Zhang, N., Zhang, Y., Jia, P., Guo, Y., Tian, Y. ... Sun, Y. (2019). E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1. Molecular Medicine Reports, 20, 1561-1568. https://doi.org/10.3892/mmr.2019.10394
MLA
Li, X., Zhang, N., Zhang, Y., Jia, P., Guo, Y., Tian, Y., You, S., Wu, S., Sun, Y."E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1". Molecular Medicine Reports 20.2 (2019): 1561-1568.
Chicago
Li, X., Zhang, N., Zhang, Y., Jia, P., Guo, Y., Tian, Y., You, S., Wu, S., Sun, Y."E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1". Molecular Medicine Reports 20, no. 2 (2019): 1561-1568. https://doi.org/10.3892/mmr.2019.10394