1
|
Chalhoub N and Baker SJ: PTEN and the
PI3-kinase pathway in cancer. Annu Rev Pathol. 4:127–150. 2009.
View Article : Google Scholar : PubMed/NCBI
|
2
|
Steck PA, Pershouse MA, Jasser SA, Yung
WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T,
et al: Identification of a candidate tumour suppressor gene, MMAC1,
at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Nat Genet. 15:356–362. 1997. View Article : Google Scholar : PubMed/NCBI
|
3
|
Di Cristofano A and Pandolfi PP: The
multiple roles of PTEN in tumor suppression. Cell. 100:387–390.
2000. View Article : Google Scholar : PubMed/NCBI
|
4
|
Salmena L, Carracedo A and Pandolfi PP:
Tenets of PTEN tumor suppression. Cell. 133:403–414. 2008.
View Article : Google Scholar : PubMed/NCBI
|
5
|
Yin Y and Shen WH: PTEN: A new guardian of
the genome. Oncogene. 27:5443–5453. 2008. View Article : Google Scholar : PubMed/NCBI
|
6
|
Carracedo A and Pandolfi PP: The PTEN-PI3K
pathway: Of feedbacks and cross-talks. Oncogene. 27:5527–5541.
2008. View Article : Google Scholar : PubMed/NCBI
|
7
|
Berger AH and Pandolfi PP:
Haplo-insufficiency: A driving force in cancer. J Pathol.
223:137–146. 2011. View Article : Google Scholar : PubMed/NCBI
|
8
|
Shen WH, Balajee AS, Wang J, Wu H, Eng C,
Pandolfi PP and Yin Y: Essential role for nuclear PTEN in
maintaining chromosomal integrity. Cell. 128:157–170. 2007.
View Article : Google Scholar : PubMed/NCBI
|
9
|
Song MS, Carracedo A, Salmena L, Song SJ,
Egia A, Malumbres M and Pandolfi PP: Nuclear PTEN regulates the
APC-CDH1 tumor-suppressive complex in a phosphatase-independent
manner. Cell. 144:187–199. 2011. View Article : Google Scholar : PubMed/NCBI
|
10
|
Chen ZH, Zhu M, Yang J, Liang H, He J, He
S, Wang P, Kang X, McNutt MA, Yin Y and Shen WH: PTEN interacts
with histone H1 and controls chromatin condensation. Cell Rep.
8:2003–2014. 2014. View Article : Google Scholar : PubMed/NCBI
|
11
|
He J, Kang X, Yin Y, Chao KS and Shen WH:
PTEN regulates DNA replication progression and stalled fork
recovery. Nat Commun. 6:76202015. View Article : Google Scholar : PubMed/NCBI
|
12
|
Kang X, Song C, Du X, Zhang C, Liu Y,
Liang L, He J, Lamb K, Shen WH and Yin Y: PTEN stabilizes TOP2A and
regulates the DNA decatenation. Sci Rep. 5:178732015. View Article : Google Scholar : PubMed/NCBI
|
13
|
Puc J, Keniry M, Li HS, Pandita TK,
Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE,
et al: Lack of PTEN sequesters CHK1 and initiates genetic
instability. Cancer Cell. 7:193–204. 2005. View Article : Google Scholar : PubMed/NCBI
|
14
|
Sun Z, Huang C, He J, Lamb KL, Kang X, Gu
T, Shen WH and Yin Y: PTEN C-terminal deletion causes genomic
instability and tumor development. Cell Rep. 6:844–854. 2014.
View Article : Google Scholar : PubMed/NCBI
|
15
|
Schuyler SC, Wu YF and Kuan VJ: The
Mad1-Mad2 balancing act-a damaged spindle checkpoint in chromosome
instability and cancer. J Cell Sci. 125:4197–4206. 2012. View Article : Google Scholar : PubMed/NCBI
|
16
|
Musacchio A: The molecular biology of
spindle assembly checkpoint signaling dynamics. Curr Biol.
25:R1002–R1018. 2015. View Article : Google Scholar : PubMed/NCBI
|
17
|
Shandilya J and Roberts SG: A role of WT1
in cell division and genomic stability. Cell Cycle. 14:1358–1364.
2015. View Article : Google Scholar : PubMed/NCBI
|
18
|
Han JS, Holland AJ, Fachinetti D, Kulukian
A, Cetin B and Cleveland DW: Catalytic assembly of the mitotic
checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional
switch in Cdc20. Mol Cell. 51:92–104. 2013. View Article : Google Scholar : PubMed/NCBI
|
19
|
Lau DT and Murray AW: Mad2 and Mad3
cooperate to arrest budding yeast in mitosis. Curr Biol.
22:180–190. 2012. View Article : Google Scholar : PubMed/NCBI
|
20
|
Burds AA, Lutum AS and Sorger PK:
Generating chromosome instability through the simultaneous deletion
of Mad2 and p53. Proc Natl Acad Sci USA. 102:11296–11301. 2005.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Rao CV, Yamada HY, Yao Y and Dai W:
Enhanced genomic instabilities caused by deregulated microtubule
dynamics and chromosome segregation: A perspective from genetic
studies in mice. Carcinogenesis. 30:1469–1474. 2009. View Article : Google Scholar : PubMed/NCBI
|
22
|
Schvartzman JM, Duijf PH, Sotillo R, Coker
C and Benezra R: Mad2 is a critical mediator of the chromosome
instability observed upon Rb and p53 pathway inhibition. Cancer
Cell. 19:701–714. 2011. View Article : Google Scholar : PubMed/NCBI
|
23
|
Feng J, Liang J, Li J, Li Y, Liang H, Zhao
X, McNutt MA and Yin Y: PTEN controls the DNA replication process
through MCM2 in response to replicative stress. Cell Rep.
13:1295–1303. 2015. View Article : Google Scholar : PubMed/NCBI
|
24
|
Ramaswamy S, Nakamura N, Vazquez F, Batt
DB, Perera S, Roberts TM and Sellers WR: Regulation of G1
progression by the PTEN tumor suppressor protein is linked to
inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc
Natl Acad Sci USA. 96:2110–2115. 1999. View Article : Google Scholar : PubMed/NCBI
|
25
|
He J, Zhang Z, Ouyang M, Yang F, Hao H,
Lamb KL, Yang J, Yin Y and Shen WH: PTEN regulates EG5 to control
spindle architecture and chromosome congression during mitosis. Nat
Commun. 7:123552016. View Article : Google Scholar : PubMed/NCBI
|
26
|
Wang LG, Liu XM, Kreis W and Budman DR:
The effect of antimicrotubule agents on signal transduction
pathways of apoptosis: A review. Cancer Chemother Pharmacol.
44:355–361. 1999. View Article : Google Scholar : PubMed/NCBI
|
27
|
Wang TH, Wang HS and Soong YK:
Paclitaxel-induced cell death: Where the cell cycle and apoptosis
come together. Cancer. 88:2619–2628. 2000. View Article : Google Scholar : PubMed/NCBI
|
28
|
Shandilya J, Toska E, Richard DJ, Medler
KF and Roberts SG: WT1 interacts with MAD2 and regulates mitotic
checkpoint function. Nat Commun. 5:49032014. View Article : Google Scholar : PubMed/NCBI
|
29
|
Homer HA, McDougall A, Levasseur M, Yallop
K, Murdoch AP and Herbert M: Mad2 prevents aneuploidy and premature
proteolysis of cyclin B and securin during meiosis I in mouse
oocytes. Genes Dev. 19:202–207. 2005. View Article : Google Scholar : PubMed/NCBI
|
30
|
Michel LS, Liberal V, Chatterjee A,
Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV
and Benezra R: MAD2 haplo-insufficiency causes premature anaphase
and chromosome instability in mammalian cells. Nature. 409:355–359.
2001. View
Article : Google Scholar : PubMed/NCBI
|
31
|
Trotman LC, Wang X, Alimonti A, Chen Z,
Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo
C, Erdjument-Bromage H, et al: Ubiquitination regulates PTEN
nuclear import and tumor suppression. Cell. 128:141–156. 2007.
View Article : Google Scholar : PubMed/NCBI
|
32
|
Hernando E, Nahlé Z, Juan G,
Diaz-Rodriguez E, Alaminos M, Hemann M, Michel L, Mittal V, Gerald
W, Benezra R, et al: Rb inactivation promotes genomic instability
by uncoupling cell cycle progression from mitotic control. Nature.
430:797–802. 2004. View Article : Google Scholar : PubMed/NCBI
|
33
|
Guardavaccaro D, Frescas D, Dorrello NV,
Peschiaroli A, Multani AS, Cardozo T, Lasorella A, Iavarone A,
Chang S, Hernando E and Pagano M: Control of chromosome stability
by the beta-TrCP-REST-Mad2 axis. Nature. 452:365–369. 2008.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Das T, Roy KS, Chakrabarti T, Mukhopadhyay
S and Roychoudhury S: Withaferin A modulates the Spindle assembly
checkpoint by degradation of Mad2-Cdc20 complex in colorectal
cancer cell lines. Biochem Pharmacol. 91:31–39. 2014. View Article : Google Scholar : PubMed/NCBI
|
35
|
Osmundson EC, Ray D, Moore FE, Gao Q,
Thomsen GH and Kiyokawa H: The HECT E3 ligase Smurf2 is required
for Mad2-dependent spindle assembly checkpoint. J Cell Biol.
183:267–277. 2008. View Article : Google Scholar : PubMed/NCBI
|
36
|
Choi YH, Kim YJ, Jeong HM, Jin YH, Yeo CY
and Lee KY: Akt enhances Runx2 protein stability by regulating
Smurf2 function during osteoblast differentiation. FEBS J.
281:3656–3666. 2014. View Article : Google Scholar : PubMed/NCBI
|
37
|
Zhang Z, Hou SQ, He J, Gu T, Yin Y and
Shen WH: PTEN regulates PLK1 and controls chromosomal stability
during cell division. Cell Cycle. 15:2476–2485. 2016. View Article : Google Scholar : PubMed/NCBI
|
38
|
Sagona AP, Nezis IP, Pedersen NM, Liestøl
K, Poulton J, Rusten TE, Skotheim RI, Raiborg C and Stenmark H:
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment
of FYVE-CENT to the midbody. Nat Cell Biol. 12:362–371. 2010.
View Article : Google Scholar : PubMed/NCBI
|
39
|
Radu A, Neubauer V, Akagi T, Hanafusa H
and Georgescu MM: PTEN induces cell cycle arrest by decreasing the
level and nuclear localization of cyclin D1. Mol Cell Biol.
23:6139–6149. 2003. View Article : Google Scholar : PubMed/NCBI
|
40
|
Wang L, Yang L, Lu Y, Chen Y, Liu T, Peng
Y, Zhou Y, Cao Y, Bi Z, Liu T, et al: Osthole induces cell cycle
arrest and inhibits migration and invasion via PTEN/Akt pathways in
osteosarcoma. Cell Physiol Biochem. 38:2173–2182. 2016. View Article : Google Scholar : PubMed/NCBI
|
41
|
Xiong X, Ren HZ, Li MH, Mei JH, Wen JF and
Zheng CL: Down-regulated miRNA-214 induces a cell cycle G1 arrest
in gastric cancer cells by up-regulating the PTEN protein. Pathol
Oncol Res. 17:931–937. 2011. View Article : Google Scholar : PubMed/NCBI
|
42
|
Bolanos-Garcia VM: Assessment of the
mitotic spindle assembly checkpoint (SAC) as the target of
anticancer therapies. Curr Cancer Drug Targets. 9:131–141. 2009.
View Article : Google Scholar : PubMed/NCBI
|
43
|
Dominguez-Brauer C, Thu KL, Mason JM,
Blaser H, Bray MR and Mak TW: Targeting mitosis in cancer: Emerging
strategies. Mol Cell. 60:524–536. 2015. View Article : Google Scholar : PubMed/NCBI
|
44
|
Huang HC, Shi J, Orth JD and Mitchison TJ:
Evidence that mitotic exit is a better cancer therapeutic target
than spindle assembly. Cancer Cell. 16:347–358. 2009. View Article : Google Scholar : PubMed/NCBI
|
45
|
Malumbres M and Barbacid M: Cell cycle,
CDKs and cancer: A changing paradigm. Nat Rev Cancer. 9:153–166.
2009. View Article : Google Scholar : PubMed/NCBI
|
46
|
Cicenas J, Kalyan K, Sorokinas A, Jatulyte
A, Valiunas D, Kaupinis A and Valius M: Highlights of the latest
advances in research on CDK inhibitors. Cancers (Basel).
6:2224–2242. 2014. View Article : Google Scholar : PubMed/NCBI
|