Open Access

Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1

  • Authors:
    • Xuejiao Zhou
    • Qian Chen
    • Hao Huang
    • Jun Zhang
    • Jing Wang
    • Ya Chen
    • Yan Peng
    • Haiqing Zhang
    • Junwei Zeng
    • Zhanhui Feng
    • Zucai Xu
  • View Affiliations

  • Published online on: October 19, 2020     https://doi.org/10.3892/mmr.2020.11614
  • Pages: 5348-5357
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epilepsy is a chronic nervous system disease. Excessive increase of the excitatory neurotransmitter glutamate in the body results in an imbalance of neurotransmitters and excessive excitation of neurons, leading to epileptic seizures. Long‑term recurrent seizures lead to behavior and cognitive changes, and even increase the risk of death by 2‑ to 3‑fold relative to the general population. Adenosine A1 receptor (A1R), a member of the adenosine system, has notable anticonvulsant effects, and adenosine levels are controlled by the type 1 equilibrative nucleoside transporter (ENT1); in addition the p38 MAPK signaling pathway is involved in the regulation of ENT1, although the effect of its inhibitors on the expression levels of A1R and ENT1 is unclear. Therefore, in the present study, SB203580 was used to inhibit the p38 MAPK signaling pathway in rats, and the expression levels of A1R and ENT1 in the brain tissue of rats with acute LiCl‑pilocarpine‑induced status epilepticus was detected. SB203580 decreased pathological damage of hippocampal neurons, prolonged seizure latency, reduced the frequency of seizures, and decreased levels of A1R and ENT1 protein in rats.
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December-2020
Volume 22 Issue 6

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Spandidos Publications style
Zhou X, Chen Q, Huang H, Zhang J, Wang J, Chen Y, Peng Y, Zhang H, Zeng J, Feng Z, Feng Z, et al: Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1. Mol Med Rep 22: 5348-5357, 2020.
APA
Zhou, X., Chen, Q., Huang, H., Zhang, J., Wang, J., Chen, Y. ... Xu, Z. (2020). Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1. Molecular Medicine Reports, 22, 5348-5357. https://doi.org/10.3892/mmr.2020.11614
MLA
Zhou, X., Chen, Q., Huang, H., Zhang, J., Wang, J., Chen, Y., Peng, Y., Zhang, H., Zeng, J., Feng, Z., Xu, Z."Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1". Molecular Medicine Reports 22.6 (2020): 5348-5357.
Chicago
Zhou, X., Chen, Q., Huang, H., Zhang, J., Wang, J., Chen, Y., Peng, Y., Zhang, H., Zeng, J., Feng, Z., Xu, Z."Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1". Molecular Medicine Reports 22, no. 6 (2020): 5348-5357. https://doi.org/10.3892/mmr.2020.11614