Open Access

Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review)

  • Authors:
    • Nnenna Elebo
    • Pascaline Fru
    • Jones Omoshoro‑Jones
    • Geoffrey Patrick Candy
    • Ekene Emmanuel Nweke
  • View Affiliations

  • Published online on: October 21, 2020     https://doi.org/10.3892/mmr.2020.11622
  • Pages: 4981-4991
  • Copyright: © Elebo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer is an aggressive cancer, making it a leading cause of cancer‑related deaths. It is characteristically resistant to treatment, which results in low survival rates. In pancreatic cancer, immune cells undergo transitions that can inhibit or promote their functions, enabling treatment resistance and tumor progression. These transitions can be fostered by metabolic pathways that are dysregulated during tumorigenesis. The present review aimed to summarize the different immune cells and their roles in pancreatic cancer. The review also highlighted the individual metabolic pathways in pancreatic cancer and how they enable transitions in immune cells. Finally, the potential of targeting metabolic pathways for effective therapeutic strategies was considered.
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December-2020
Volume 22 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Elebo N, Fru P, Omoshoro‑Jones J, Patrick Candy G and Nweke EE: Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review). Mol Med Rep 22: 4981-4991, 2020.
APA
Elebo, N., Fru, P., Omoshoro‑Jones, J., Patrick Candy, G., & Nweke, E.E. (2020). Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review). Molecular Medicine Reports, 22, 4981-4991. https://doi.org/10.3892/mmr.2020.11622
MLA
Elebo, N., Fru, P., Omoshoro‑Jones, J., Patrick Candy, G., Nweke, E. E."Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review)". Molecular Medicine Reports 22.6 (2020): 4981-4991.
Chicago
Elebo, N., Fru, P., Omoshoro‑Jones, J., Patrick Candy, G., Nweke, E. E."Role of different immune cells and metabolic pathways in modulating the immune response in pancreatic cancer (Review)". Molecular Medicine Reports 22, no. 6 (2020): 4981-4991. https://doi.org/10.3892/mmr.2020.11622