Role of connexins in neurodegenerative diseases (Review)

  • Authors:
    • Juping Xing
    • Changshui Xu
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  • Published online on: March 23, 2021     https://doi.org/10.3892/mmr.2021.12034
  • Article Number: 395
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Abstract

Neurodegenerative diseases are neurological disorders characterized by progressive neuronal degeneration, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis and Huntington's disease. The neuronal damage caused by these diseases may be associated with abnormal alterations of connexins in glia. These changes may cause glia to lose their ability to support and protect neurons and induce abnormal increases in levels of ions and metabolites, such as calcium ions, glutamate and ATP, around neurons. These processes eventuallys lead to neuronal death. In the present review, the abnormal expression of connexin and its primary role in neurodegenerative diseases was investigated.
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May-2021
Volume 23 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Xing J and Xu C: Role of connexins in neurodegenerative diseases (Review). Mol Med Rep 23: 395, 2021.
APA
Xing, J., & Xu, C. (2021). Role of connexins in neurodegenerative diseases (Review). Molecular Medicine Reports, 23, 395. https://doi.org/10.3892/mmr.2021.12034
MLA
Xing, J., Xu, C."Role of connexins in neurodegenerative diseases (Review)". Molecular Medicine Reports 23.5 (2021): 395.
Chicago
Xing, J., Xu, C."Role of connexins in neurodegenerative diseases (Review)". Molecular Medicine Reports 23, no. 5 (2021): 395. https://doi.org/10.3892/mmr.2021.12034