Acute spinal cord injury: Pathophysiology and pharmacological intervention (Review)
- Authors:
- Yi Zhang
- Abdullah Al Mamun
- Yuan Yuan
- Qi Lu
- Jun Xiong
- Shulin Yang
- Chengbiao Wu
- Yanqing Wu
- Jian Wang
-
Affiliations: School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P.R. China, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China, Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, P.R. China, Department of Hand Surgery and Peripheral Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China - Published online on: March 31, 2021 https://doi.org/10.3892/mmr.2021.12056
- Article Number: 417
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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 |
|
Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M and Del Popolo G: Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury. World J Urol. 36:1517–1527. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hu HZ, Granger N and Jeffery ND: Pathophysiology, clinical importance, and management of neurogenic lower urinary tract dysfunction caused by suprasacral spinal cord injury. J Vet Intern Med. 30:1575–1588. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Elliott CS, Dallas KB, Zlatev D, Comiter CV, Crew J and Shem K: Volitional voiding of the bladder after spinal cord injury: Validation of bilateral lower extremity motor Function as a key predictor. J Urol. 200:154–160. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma HS: Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: Novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection. J Neural Transm (Vienna). 118:155–176. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Tator CH: Experimental and clinical studies of the pathophysiology and management of acute spinal cord injury. J Spinal Cord Med. 19:206–214. 1996. View Article : Google Scholar : PubMed/NCBI | |
|
Hulsebosch CE: Recent advances in pathophysiology and treatment of spinal cord injury. Adv Physiol Educ. 26:238–255. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Tator CH and Deecke L: Studies of the treatment and pathophysiology of acute spinal cord injury in primates. Paraplegia. 10:344–345. 1973.PubMed/NCBI | |
|
Xiong Y and Hall ED: Pharmacological evidence for a role of peroxynitrite in the pathophysiology of spinal cord injury. Exp Neurol. 216:105–114. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Wasner G, Naleschinski D and Baron R: A role for peripheral afferents in the pathophysiology and treatment of at-level neuropathic pain in spinal cord injury? A case report. Pain. 131:219–225. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Vaidyanathan S, Soni BM, Sett P, Watt JW, Oo T and Bingley J: Pathophysiology of autonomic dysreflexia: Long-term treatment with terazosin in adult and paediatric spinal cord injury patients manifesting recurrent dysreflexic episodes. Spinal Cord. 36:761–770. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Austin JW, Afshar M and Fehlings MG: The relationship between localized subarachnoid inflammation and parenchymal pathophysiology after spinal cord injury. J Neurotrauma. 29:1838–1849. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Yezierski RP: Pain following spinal cord injury: Pathophysiology and central mechanisms. Prog Brain Res. 129:429–449. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Nickel M and Gu C: Regulation of central nervous system myelination in higher brain functions. Neural Plast. 2018:64364532018. View Article : Google Scholar : PubMed/NCBI | |
|
Fehlings MG and Agrawal S: Role of sodium in the pathophysiology of secondary spinal cord injury. Spine (Phila Pa 1976). 20:2187–2191. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Schwartz G and Fehlings MG: Secondary injury mechanisms of spinal cord trauma: A novel therapeutic approach for the management of secondary pathophysiology with the sodium channel blocker riluzole. Prog Brain Res. 137:177–190. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma HS, Patnaik R, Sharma A, Sjoquist PO and Lafuente JV: Silicon dioxide nanoparticles (SiO2, 40–50 nm) exacerbate pathophysiology of traumatic spinal cord injury and deteriorate functional outcome in the rat. An experimental study using pharmacological and morphological approaches. J Nanosci Nanotechnol. 9:4970–4980. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Valles M and Mearin F: Pathophysiology of bowel dysfunction in patients with motor incomplete spinal cord injury: Comparison with patients with motor complete spinal cord injury. Dis Colon Rectum. 52:1589–1597. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Agrawal SK, Nashmi R and Fehlings MG: Role of L- and N-type calcium channels in the pathophysiology of traumatic spinal cord white matter injury. Neuroscience. 99:179–188. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Furlan JC and Fehlings MG: Cardiovascular complications after acute spinal cord injury: Pathophysiology, diagnosis, and management. Neurosurg Focus. 25:E132008. View Article : Google Scholar : PubMed/NCBI | |
|
Hayta E and Elden H: Acute spinal cord injury: A review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention. J Chem Neuroanat. 87:25–31. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hall ED: Pathophysiology of spinal cord injury. Current and future therapies. Minerva Anestesiol. 55:63–66. 1989.PubMed/NCBI | |
|
Segal JL: Immunoactivation and altered intercellular communication mediate the pathophysiology of spinal cord injury. Pharmacotherapy. 25:145–156. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Delamarter RB, Sherman J and Carr JB: Pathophysiology of spinal cord injury. Recovery after immediate and delayed decompression. J Bone Joint Surg Am. 77:1042–1049. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Santos-Nogueira E, López-Serrano C, Hernandez J, Lago N, Astudillo AM, Balsinde J, Estivill-Torrús G, de Fonseca FR, Chun J and López-Vales R: Activation of Lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury. J Neurosci. 35:10224–10235. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma HS, Badgaiyan RD, Alm P, Mohanty S and Wiklund L: Neuroprotective effects of nitric oxide synthase inhibitors in spinal cord injury-induced pathophysiology and motor functions: An experimental study in the rat. Ann N Y Acad Sci. 1053:422–434. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Karimi-Abdolrezaee S, Eftekharpour E and Fehlings MG: Temporal and spatial patterns of Kv1.1 and Kv1.2 protein and gene expression in spinal cord white matter after acute and chronic spinal cord injury in rats: Implications for axonal pathophysiology after neurotrauma. Eur J Neurosci. 19:577–589. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Tator CH: Acute spinal cord injury: A review of recent studies of treatment and pathophysiology. Can Med Assoc J. 107:143–145. 1972.PubMed/NCBI | |
|
Sharma HS, Muresanu DF, Sharma A, Patnaik R and Lafuente JV: Chapter 9-nanoparticles influence pathophysiology of spinal cord injury and repair. Prog Brain Res. 180:154–180. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Neal JM, Kopp SL, Pasternak JJ, Lanier WL and Rathmell JP: Anatomy and pathophysiology of spinal cord injury associated with regional anesthesia and pain medicine: 2015 update. Reg Anesth Pain Med. 40:506–525. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang X, Cao K, Sun X, Chen Y, Duan Z, Sun L, Guo L, Bai P, Sun D, Fan J, et al: Macrophages in spinal cord injury: Phenotypic and functional change from exposure to myelin debris. Glia. 63:635–651. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Eldahan KC and Rabchevsky AG: Autonomic dysreflexia after spinal cord injury: Systemic pathophysiology and methods of management. Auton Neurosci. 209:59–70. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma HS: Neurotrophic factors in combination: A possible new therapeutic strategy to influence pathophysiology of spinal cord injury and repair mechanisms. Curr Pharm Des. 13:1841–1874. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Siddiqui TA, Lively S and Schlichter LC: Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation. 13:662016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou LH, Ouyang L, Lin SZ, Chen S, Liu Y, Zhou W and Wang X: Protective role of β-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury. Int Immunopharmacol. 61:92–99. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Yao X, Zhang Y, Hao J, Duan HQ, Zhao CX, Sun C, Li B, Fan BY, Wang X, Li WX, et al: Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis. Neural Regen Res. 14:532–541. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang D, Wang F, Zhai X, Li XH and He XJ: Lithium promotes recovery of neurological function after spinal cord injury by inducing autophagy. Neural Regen Res. 13:2191–2199. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou LY, Song ZF, Zhou LW, Qiu Y, Hu N, Hu Y and Hu X: Protective role of astragalus injection in spinal cord ischemia-reperfusion injury in rats. Neurosciences (Riyadh). 23:116–121. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sharma HS: Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des. 11:1353–1389. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Aarabi B, Olexa J, Chryssikos T, Galvagno SM, Hersh DS, Wessell A, Sansur C, Schwartzbauer G, Crandall K, et al: Extent of Spinal Cord Decompression in Motor Complete (American Spinal Injury Association Impairment Scale Grades A and B) Traumatic Spinal Cord Injury Patients: Post-Operative Magnetic Resonance Imaging Analysis of Standard Operative Approaches. J Neurotrauma. 36:862–876. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Akhmetzyanova ER, Mukhamedshina YO, Zhuravleva MN, Galieva LR, Kostennikov AA, Garanina EE and Rizvanov AA: Transplantation of microglia in the area of spinal cord injury in an acute period increases tissue sparing, but not functional recovery. Front Cell Neurosci. 12:5072018. View Article : Google Scholar : PubMed/NCBI | |
|
Aguiar SA, Baker SN, Gant K, Bohorquez J and Thomas CK: Spasms after spinal cord injury show low-frequency intermuscular coherence. J Neurophysiol. 120:1765–1771. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tang Y, Liu HL, Min LX, Yuan HS, Guo L, Han PB, Lu YX, Zhong JF and Wang DL: Serum and cerebrospinal fluid tau protein level as biomarkers for evaluating acute spinal cord injury severity and motor function outcome. Neural Regen Res. 14:896–902. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Alizadeh A, Santhosh K, Kataria H and Karimi-Abdolrezaee S: Neuregulin-1 positively modulates neuroinflammation and improves functional recovery following traumatic spinal cord injury. J Neurotrauma. 35:A32. 2018. | |
|
Baklaushev VP, Durov OV, Kim SV, Gulaev EV, Gubskiy IL, Konoplyannikov MA, Zabozlaev FG, Zhang C, Agrba VZ, Orlov SV, et al: Development of a motor and somatosensory evoked potentials-guided spinal cord Injury model in non-human primates. J Neurosci Methods. 311:200–214. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Bonizzato M, Pidpruzhnykova G, DiGiovanna J, Shkorbatova P, Pavlova N, Micera S and Courtine G: Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury. Nat Commun. 9:30152018. View Article : Google Scholar : PubMed/NCBI | |
|
Burnside ER, De Winter F, Didangelos A, James ND, Andreica EC, Layard-Horsfall H, Muir EM, Verhaagen J and Bradbury EJ: Immune-evasive gene switch enables regulated delivery of chondroitinase after spinal cord injury. Brain. 141:2362–2381. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Casper DS, Zmistowski B, Schroeder GD, McKenzie JC, Mangan J, Vatson J, Hilibrand AS, Vaccaro AR and Kepler CK: Preinjury patient characteristics and postinjury neurological status are associated with mortality following spinal cord injury. Spine (Phila Pa 1976). 43:895–899. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
David S, Kroner A, Greenhalgh AD, Zarruk JG and Lopez-Vales R: Myeloid cell responses after spinal cord injury. J Neuroimmunol. 321:97–108. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chhaya SJ, Quiros-Molina D, Tamashiro-Orrego AD, Houle JD and Detloff MR: Exercise-induced changes to the macrophage response in the dorsal root ganglia prevent neuropathic pain after spinal cord injury. J Neurotrauma. 36:877–890. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chi LY, Yu J, Zhu H, Li XG, Zhu SG and Kindy MS: The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury. Neurosci Lett. 438:174–179. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lv RX, Du LL, Zhang LX and Zhang ZQ: Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway. Life Sci. 217:119–127. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ziegler G, Grabher P, Thompson A, Altmann D, Hupp M, Ashburner J, Friston K, Weiskopf N, Curt A and Freund P: Progressive neurodegeneration following spinal cord injury Implications for clinical trials. Neurology. 90:e1257–e1266. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou QS, Xiang HK, Li A, Lin W, Huang Z, Guo J, Wang P, Chi Y, Xiang K, Xu Y, et al: Activating adiponectin signaling with exogenous AdipoRon reduces myelin lipid accumulation and suppresses macrophage recruitment after spinal cord injury. J Neurotrauma. 36:903–918. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Cizkova D, Cubinkova V, Smolek T, Murgoci AN, Danko J, Vdoviakova K, Humenik F, Cizek M, Quanico J, Fournier I, Salzet M; Correction, ; Cizkova D..et al: Localized intrathecal delivery of mesenchymal stromal cells conditioned media improves functional recovery in a rat model of contusive spinal cord injury. Int. J. Mol. Sci. 2018.19, 870. Int J Mol Sci 19: 1942, 2018. View Article : Google Scholar | |
|
de Menezes MF, Nicola F, Vital da Silva IR, Vizuete A, Elsner VR, Xavier LL, Gonçalves CAS, Netto CA and Mestriner RG: Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats. Neural Regen Res. 13:1945–1952. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Faden AI and Holaday JW: A role for endorphins in the pathophysiology of spinal cord injury. Adv Biochem Psychopharmacol. 28:435–446. 1981.PubMed/NCBI | |
|
O'Hare Doig RL, Santhakumar S, Fehily B, Raja S, Solomon T, Bartlett CA, Fitzgerald M and Hodgetts SI: Acute cellular and functional changes with a combinatorial treatment of ion channel inhibitors following spinal cord injury. Front Mol Neurosci. 13(85)https://doi.org/10.3389/fnmol.2020.000852020. | |
|
Durdag E, Yildirim Z, Unlu NL, Kale A and Ceviker N: Neuroprotective effects of vigabatrin on spinal cord ischemia-reperfusion injury. World Neurosurg. 120:e33–e41. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Dietrich WD: Clinical significance and potential translation of neural regeneration and functional recovery in monkeys after spinal cord injury. Sci China Life Sci. 61:1291–1292. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Olsson Y, Sharma HS, Nyberg F and Westman J: The opioid receptor antagonist naloxone influences the pathophysiology of spinal cord injury. Prog Brain Res. 104:381–399. 1995. View Article : Google Scholar : PubMed/NCBI | |
|
Young W, Flamm ES, Demopoulos HB, Tomasula JJ and DeCrescito V: Effect of naloxone on posttraumatic ischemia in experimental spinal contusion. J Neurosurg. 55:209–219. 1981. View Article : Google Scholar : PubMed/NCBI | |
|
Yadollahi M, Kashkooe A, Habibpour E and Jamali K: Prevalence and risk factors of spinal trauma and spinal cord injury in a trauma center in Shiraz, Iran. Iran Red Crescent Med J. Feb;2018.doi: 10.5812/ircmj.14238. View Article : Google Scholar | |
|
Hogan MK, Zhao TY, Kondiles B, Sellers D, Pun SZ and Horner P: Controlled release of thrombin-inhibitor from injectable hydrogel modulates gliosis after spinal cord injury. J Neurotrauma. 35:A37. 2018. | |
|
Huber E, David G, Thompson AJ, Weiskopf N, Mohammadi S and Freund P: Dorsal and ventral horn atrophy is associated with clinical outcome after spinal cord injury. Neurology. 90:e1510–e1522. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Huang WH, Bai XS, Stopper L, Catalin B, Cartarozzi LP, Scheller A and Kirchhoff F: During development NG2 glial cells of the spinal cord are restricted to the oligodendrocyte lineage, but generate astrocytes upon acute injury. Neuroscience. 385:154–165. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hupp M, Pavese C, Bachmann LM, Koller R and Schubert M; EMSCI Study Group, : Electrophysiological multimodal assessments improve outcome prediction in traumatic cervical spinal cord injury. J Neurotrauma. 35:2916–2923. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Kaptanoglu E, Okutan O, Akbiyik F, Solaroglu I, Kilinc A and Beskonakli E: Correlation of injury severity and tissue Evans blue content, lipid peroxidation and clinical evaluation in acute spinal cord injury in rats. J Clin Neurosci. 11:879–885. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Irrera N, Arcoraci V, Mannino F, Vermiglio G, Pallio G, Minutoli L, Bagnato G, Anastasi GP, Mazzon E, Bramanti P, et al: Activation of A2A receptor by PDRN reduces neuronal damage and stimulates WNT/β-CATENIN driven neurogenesis in spinal cord injury. Front Pharmacol. 9:5062018. View Article : Google Scholar : PubMed/NCBI | |
|
Huo J, Ma R, Chai X, Liang HJ, Jiang P, Zhu XL, Chen X and Su BX: Inhibiting a spinal cord signaling pathway protects against ischemia injury in rats. J Thorac Cardiovasc Surg. 157:494–503.e1. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Werner C and Engelhard K: Pathophysiology of traumatic brain injury. Br J Anaesth. 99:4–9. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Gu R, Zhu QS and Liu JC: Changes of spinal edema and expression of aquaporin 4 in methylprednisolone-treated rats with spinal cord injury. Ann Clin Lab Sci. 48:453–459. 2018.PubMed/NCBI | |
|
Jaja B, Jiang F, Badhiwala J, Fehlings MG and Wilson J: Neurological recovery and functional outcomes following acquired infections after acute spinal cord injury. J Neurotrauma. 35:A177–A178. 2018. | |
|
Lanza M, Campolo M, Casili G, Filippone A, Cuzzocrea S and Esposito E: Sodium butyrate exerts neuroprotective effects in spinal cord injury. FASEB J. 32:8242018. | |
|
DeForge D, Nymark J, Lemaire E, Gardner S, Hunt M, Martel L, Curran D and Barbeau H: Effect of 4-aminopyridine on gait in ambulatory spinal cord injuries: A double-blind, placebo-controlled, crossover trial. Spinal Cord. 42:674–685. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Hall ED: Antioxidant therapies for acute spinal cord injury. Neurotherapeutics. 8:152–167. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wang HJ, Cahoon R, Cahoon EB, Zheng H, Patel KP and Zucker IH: Glutamatergic receptor dysfunction in spinal cord contributes to the exaggerated exercise pressor reflex in heart failure. Am J Physiol Heart Circ Physiol. 308:H447–H455. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Winkler T, Sharma HS, Stalberg E, Badgaiyan RD, Gordh T and Westman J: An L-type calcium channel blocker, nimodipine influences trauma induced spinal cord conduction and axonal injury in the rat. Acta Neurochir Suppl. 86:425–432. 2003.PubMed/NCBI | |
|
Kusuyama K, Tachibana T, Yamanaka H, Okubo M, Yoshiya S and Noguchi K: Upregulation of calcium channel alpha-2-delta-1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia. Spine J. 18:1062–1069. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen YM, Wang BL and Zhao H: Thymoquinone reduces spinal cord injury by inhibiting inflammatory response, oxidative stress and apoptosis via PPAR-γ and PI3K/Akt pathways. Exp Ther Med. 15:4987–4994. 2018.PubMed/NCBI | |
|
Damon Y, Kitano Y and Makino M: Analgesic effects of the novel α2δ ligand mirogabalin in a rat model of spinal cord injury. Pharmazie. 73:659–661. 2018.PubMed/NCBI | |
|
Chaves RHD, de Souza CC, Furlaneto IP, Teixeira RKC, Oliveira CP, Rodrigues EM, Santos DASD, Silva RC, Penha NEAD and Lima AR: Influence of tramadol on functional recovery of acute spinal cord injury in rats. Acta Cir Bras. 33:1087–1094. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Harada N, Taoka Y and Okajima K: Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats. J Neurotrauma. 23:1739–1749. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Sohn S: Ursodeoxycholic acid inhibits inflammatory responses and promotes functional recovery after spinal cord injury in rats. J Neurotrauma. 35:A172. 2018. | |
|
Pallottie A, Ratnayake A, Ni L, Acioglu C, Li L, Mirabelli E, Heary RF and Elkabes S: A toll-like receptor 9 antagonist restores below-level glial glutamate transporter expression in the dorsal horn following spinal cord injury. Sci Rep. 8:87232018. View Article : Google Scholar : PubMed/NCBI | |
|
Cai J, Sun Y, Yin Z, Wang D, Shi K, Fu Y, Cao X and Ge Y: Analysis of FK506-mediated functional recovery and neuroprotection in a rat model of spinal cord injury indicates that EGF is modulated in astrocytes. Exp Ther Med. 16:501–510. 2018.PubMed/NCBI | |
|
Kim YH, Ha KY and Kim SI: Spinal cord injury and related clinical trials. Clin Orthop Surg. 9:1–9. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Mori E, Ueta T, Maeda T, Ideta R, Yugué I, Kawano O and Shiba K: Sequential neurological improvements after conservative treatment in patients with complete motor paralysis caused by cervical spinal cord injury without bone and disc injury. J Neurosurg Spine. 29:1–9. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen S, Ye J, Chen X, Shi J, Wu W, Lin W, Lin W, Li Y, Fu H and Li S: Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-κB pathway dependent of HDAC3. J Neuroinflammation. 15:1502018. View Article : Google Scholar : PubMed/NCBI | |
|
Mongardon N, Kohlhauer M, Lidouren F, Barretto M, Micheau P, Adam C, Dhonneur G, Ghaleh B and Tissier R: Targeted temperature management with total liquid ventilation after ischemic spinal cord injury. Ann Thorac Surg. 106:1797–1803. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chang MC: Spinal Cord injury by direct damage during CT-Guided C7 transforaminal epidural steroid injection. Am J Phys Med Rehabil. 97:e62–e64. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sámano C and Nistri A: Mechanism of neuroprotection against experimental spinal cord injury by riluzole or methylprednisolone. Neurochem Res. 44:200–213. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ye JC, Qin Y, Tang Y, Ma M, Wang P, Huang L, Yang R, Chen K, Chai C, Wu Y and Shen H: Methylprednisolone inhibits the proliferation of endogenous neural stem cells in nonhuman primates with spinal cord injury. J Neurosurg Spine. 29:199–207. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chu TH, Cummins K and Stys PK: The triple monoamine re-uptake inhibitor DOV 216,303 promotes functional recovery after spinal cord contusion injury in mice. Neurosci Lett. 675:1–6. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ko MY, Jang EY, Lee JY, Kim SP, Whang SH, Lee BH, Kim HY, Yang CH, Cho HJ and Gwak YS: The role of ventral tegmental area gamma-aminobutyric acid in chronic neuropathic pain after spinal cord injury in rats. J Neurotrauma. 35:1755–1764. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Fehlings MG, Tator CH and Linden RD: The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg. 71:403–416. 1989. View Article : Google Scholar : PubMed/NCBI | |
|
Rosenberg LJ, Teng YD and Wrathall JR: Effects of the sodium channel blocker tetrodotoxin on acute white matter pathology after experimental contusive spinal cord injury. J Neurosci. 19:6122–6133. 1999. View Article : Google Scholar : PubMed/NCBI | |
|
Caglar YS, Demirel A, Dogan I, Huseynov R, Eroglu U, Ozgural O, Cansiz C, Bahadir B, Kilinc MC and Al-Beyati ESM: Effect of riluzole on spinal cord regeneration with hemisection method before injury. World Neurosurg. 114:e247–e253. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Verma R, Virdi JK, Singh N and Jaggi AS: Animals models of spinal cord contusion injury. Korean J Pain. 32:12–21. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Nagoshi N, Nakashima H and Fehlings MG: Riluzole as a neuroprotective drug for spinal cord injury: From bench to bedside. Molecules. 20:7775–7789. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Fehlings MG, Nakashima H, Nagoshi N, Chow DS, Grossman RG and Kopjar B: Rationale, design and critical end points for the Riluzole in acute spinal cord injury study (RISCIS): A randomized, double-blinded, placebo-controlled parallel multi-center trial. Spinal Cord. 54:8–15. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Grijalva I, García-Pérez A, Díaz J, Aguilar S, Mino D, Santiago-Rodríguez E, Guizar-Sahagún G, Castañeda- Hernández G, Maldonado-Julián H and Madrazo I: High doses of 4-aminopyridine improve functionality in chronic complete spinal cord injury patients with MRI evidence of cord continuity. Arch Med Res. 41:567–575. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Page JC, Park J, Chen Z, Cao P and Shi R: Parallel evaluation of two potassium channel blockers in restoring conduction in mechanical spinal cord injury in rat. J Neurotrauma. 35:1057–1068. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Darlington C: Fampridine acorda therapeutics. Curr Opin Investig Drugs. 1:375–379. 2000.PubMed/NCBI | |
|
Hayes KC: Impact of extended-release dalfampridine on walking ability in patients with multiple sclerosis. Neuropsychiatr Dis Treat. 7:229–239. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Proks P, Reimann F, Green N, Gribble F and Ashcroft F: Sulfonylurea stimulation of insulin secretion. Diabetes. 51 (Suppl 3):S368–S376. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Kurland DB, Tosun C, Pampori A, Karimy JK, Caffes NM, Gerzanich V and Simard JM: Glibenclamide for the treatment of acute CNS injury. Pharmaceuticals (Basel). 6:1287–1303. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Caffes N, Kurland DB, Gerzanich V and Simard JM: Glibenclamide for the treatment of ischemic and hemorrhagic stroke. Int J Mol Sci. 16:4973–4984. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Popovich PG, Lemeshow S, Gensel JC and Tovar CA: Independent evaluation of the effects of glibenclamide on reducing progressive hemorrhagic necrosis after cervical spinal cord injury. Exp Neurol. 233:615–622. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Simard JM, Tsymbalyuk O, Ivanov A, Ivanova S, Bhatta S, Geng Z, Woo SK and Gerzanich V: Endothelial sulfonylurea receptor 1-regulated NC Ca-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury. J Clin Invest. 117:2105–2113. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Simard JM, Popovich PG, Tsymbalyuk O and Gerzanich V: Spinal cord injury with unilateral versus bilateral primary hemorrhage-effects of glibenclamide. Exp Neurol. 233:829–835. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Simard JM, Woo SK, Schwartzbauer GT and Gerzanich V: Sulfonylurea receptor 1 in central nervous system injury: A focused review. J Cereb Blood Flow Metab. 32:1699–1717. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Cheung V, Hoshide R, Bansal V, Kasper E and Chen CC: Methylprednisolone in the management of spinal cord injuries: Lessons from randomized, controlled trials. Surg Neurol Int. 6:1422015. View Article : Google Scholar : PubMed/NCBI | |
|
Anwar MA, Al Shehabi TS and Eid AH: Inflammogenesis of secondary spinal cord injury. Front Cell Neurosci. 10:982016. View Article : Google Scholar : PubMed/NCBI | |
|
Bracken MB, Shepard MJ, Hellenbrand KG, Collins WF, Leo LS, Freeman DF, Wagner FC, Flamm ES, Eisenberg HM, Goodman JH, et al: Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the national acute spinal cord injury study. J Neurosurg. 63:704–713. 1985. View Article : Google Scholar : PubMed/NCBI | |
|
Sayer FT, Kronvall E and Nilsson OG: Methylprednisolone treatment in acute spinal cord injury: The myth challenged through a structured analysis of published literature. Spine J. 6:335–343. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Bracken MB, Shepard MJ, Collins WF, Holford TR, Young W, Baskin DS, Eisenberg HM, Flamm E, Leo-Summers L, Maroon J, et al: A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the second national acute spinal cord injury study. N Engl J Med. 322:1405–1411. 1990. View Article : Google Scholar : PubMed/NCBI | |
|
Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, et al: Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third national acute spinal cord injury randomized controlled trial. National acute spinal cord injury study. JAMA. 277:1597–1604. 1997. View Article : Google Scholar : PubMed/NCBI | |
|
Bracken MB: Steroids for acute spinal cord injury. Cochrane Database Syst Rev. 1:CD0010462012.PubMed/NCBI | |
|
Bowers CA, Kundu B, Rosenbluth J and Hawryluk GW: Patients with spinal cord injuries favor administration of methylprednisolone. PLoS One. 11:e01459912016. View Article : Google Scholar : PubMed/NCBI | |
|
Ferrara G, Petrillo MG, Giani T, Marrani E, Filippeschi C, Oranges T, Simonini G and Cimaz R: Clinical use and molecular action of corticosteroids in the pediatric age. Int J Mol Sci. 20:4442019. View Article : Google Scholar | |
|
Fehlings MG, Wilson JR, Tetreault LA, Aarabi B, Anderson P, Arnold PM, Brodke DS, Burns AS, Chiba K, Dettori JR, et al: A clinical practice guideline for the management of patients with acute spinal cord injury: Recommendations on the use of methylprednisolone sodium succinate. Global Spine J. 7 (Suppl 3):203S–211S. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yue JK, Tsolinas RE, Burke JF, Deng H, Upadhyayula PS, Robinson CK, Lee YM, Chan AK, Winkler EA and Dhall SS: Vasopressor support in managing acute spinal cord injury: Current knowledge. J Neurosurg Sci. 63:308–317. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Resnick DK: Updated guidelines for the management of acute cervical spine and spinal cord injury. Neurosurgery. 72 (Suppl 2):S12013. View Article : Google Scholar | |
|
Mojtahedzadeh M, Taghvaye-Masoumi H, Najafi A, Dianatkhah M, Sharifnia H and Shahrokhi M: Management of hypotension and bradycardia caused by spinal cord injury. The usefulness of midodrine and methylxanthines. Iran J Pharm Res. 18:2131–2135. 2019.PubMed/NCBI | |
|
Inoue T, Manley GT, Patel N and Whetstone WD: Medical and surgical management after spinal cord injury: Vasopressor usage, early surgerys, and complications. J Neurotrauma. 31:284–291. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hawryluk G, Whetstone W, Saigal R, Ferguson A, Talbott J, Bresnahan J, Dhall S, Pan J, Beattie M and Manley G: Mean arterial blood pressure correlates with neurological recovery after human spinal cord injury: Analysis of high frequency physiologic data. J Neurotrauma. 32:1958–1967. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Yakovlev AG and Faden AI: Mechanisms of neural cell death: Implications for development of neuroprotective treatment strategies. NeuroRx. 1:5–16. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Knoblach SM, Alroy DA, Nikolaeva M, Cernak I, Stoica BA and Faden AI: Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury. J Cereb Blood Flow Metab. 24:1119–1132. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Thomas S, Quinn BA, Das SK, Dash R, Emdad L, Dasgupta S, Wang XY, Dent P, Reed JC, Pellecchia M, et al: Targeting the Bcl-2 family for cancer therapy. Expert Opin Ther Targets. 17:61–75. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Hall ED and Springer JE: Neuroprotection and acute spinal cord injury: A reappraisal. NeuroRx. 1:80–100. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Squair JW, Ruiz I, Phillip AA, Zheng MMZ, Sarafis ZK, Sachdeva R, Gopaul R, Liu J, Tetzlaff W, West CR and Krassioukov AV: Minocycline reduces the severity of autonomic dysreflexia after experimental spinal cord injury. J Neurotrauma. 35:2861–2871. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang H, Xiang Z, Duan X, Jiang JL, Xing YM, Zhu C, Song Q and Yu QR: Antitumor and anti-inflammatory effects of oligosaccharides from Cistanche deserticola extract on spinal cord injury. Int J Biol Macromol. 124:360–367. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Scholz R, Sobotka M, Caramoy A, Stempfl T, Moehle C and Langmann T: Minocycline counter-regulates pro-inflammatory microglia responses in the retina and protects from degeneration. J Neuroinflammation. 12:2092015. View Article : Google Scholar : PubMed/NCBI | |
|
Tikka TM and Koistinaho JE: Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol. 166:7527–7533. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Wells JE, Hurlbert RJ, Fehlings MG and Yong VW: Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice. Brain. 126:1628–1637. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Curtis E, Martin JR, Gabel B, Sidhu N, Rzesiewicz TK, Mandeville R, Van Gorp S, Leerink M, Tadokoro T, Marsala S, et al: A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury. Cell Stem Cell. 22:941–950.e6. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Casha S, Zygun D, McGowan MD, Bains I, Yong VW and Hurlbert RJ: Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. Brain. 135:1224–1236. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Barros TE Jr, Araujo FF, Higino Lda P, Marcon RM and Cristante AF: The effect of monosialoganglyoside (GM-1) administration in spinal cord injury. Acta Ortop Bras. 24:123–126. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Marcon RM, Cristante AF, de Barros Filho TE, de Oliveira RP and dos Santos GB: Potentializing the effects of GM1 by hyperbaric oxygen therapy in acute experimental spinal cord lesion in rats. Spinal Cord. 48:808–813. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Badhiwala JH, Wilson JR, Kwon BK, Casha S and Fehlings MG: A Review of clinical trials in spinal cord injury including biomarkers. J Neurotrauma. 35:1906–1917. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Geisler FH, Dorsey FC and Coleman WP: Recovery of motor function after spinal-cord injury-a randomized, placebo- controlled trial with GM-1 ganglioside. N Engl J Med. 324:1829–1838. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Lee Y, Kim CY, Lee HJ, Kim JG, Han DW and Ko K, Walter J, Chung HM, Schöler HR, Bae YM and Ko K: Two-step generation of oligodendrocyte progenitor cells from mouse fibroblasts for spinal cord injury. Front Cell Neurosci. 12:1982018. View Article : Google Scholar : PubMed/NCBI | |
|
Awad BI, Carmody MA and Steinmetz MP: Potential role of growth factors in the management of spinal cord injury. World Neurosurg. 83:120–131. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Ma DN, Zhang XQ, Ying J, Chen ZJ and Li LX: Efficacy and safety of 9 nonoperative regimens for the treatment of spinal cord injury: A network meta-analysis. Medicine (Baltimore). 96:e86792017. View Article : Google Scholar : PubMed/NCBI | |
|
Teng YD, Mocchetti I and Wrathall JR: Basic and acidic fibroblast growth factors protect spinal motor neurones in vivo after experimental spinal cord injury. Eur J Neurosci. 10:798–802. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Wu JC, Huang WC, Chen YC, Tu TH, Tsai YA, Huang SF, Huang HC and Cheng H: Acidic fibroblast growth factor for repair of human spinal cord injury: A clinical trial. J Neurosurg Spine. 15:216–227. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Gupta V, Mesa RA, Deininger MW, Rivera CE, Sirhan S, Brachmann CB, Collins H, Kawashima J, Xin Y and Verstovsek S: A phase 1/2, open-label study evaluating twice-daily administration of momelotinib in myelofibrosis. Haematologica. 102:94–102. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Clarke WE, Berry M, Smith C, Kent A and Logan A: Coordination of fibroblast growth factor receptor 1 (FGFR1) and fibroblast growth factor-2 (FGF-2) trafficking to nuclei of reactive astrocytes around cerebral lesions in adult rats. Mol Cell Neurosciences. 17:17–30. 2001. View Article : Google Scholar | |
|
Raballo R, Rhee J, Lyn-Cook R, Leckman JF, Schwartz ML and Vaccarino FM: Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex. J Neuroscience. 20:5012–5023. 2000. View Article : Google Scholar | |
|
Zhou Y, Wang Z, Li J, Li X and Xiao J: Fibroblast growth factors in the management of spinal cord injury. J Cell Mol Med. 22:25–37. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ko CC, Tu TH, Wu JC, Huang WC, Tsai YA, Huang SF, Huang HC and Cheng H: Functional improvement in chronic human spinal cord injury: Four years after acidic fibroblast growth factor. Sci Rep. 8:126912018. View Article : Google Scholar : PubMed/NCBI | |
|
Wu JC, Huang WC, Tsai YA, Chen YC and Cheng H: Nerve repair using acidic fibroblast growth factor in human cervical spinal cord injury: A preliminary phase I clinical study. J Neurosurg Spine. 8:208–214. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Wallner S, Peters S, Pitzer C, Resch H, Bogdahn U and Schneider A: The Granulocyte-colony stimulating factor has a dual role in neuronal and vascular plasticity. Front Cell Dev Biol. 3:482015. View Article : Google Scholar : PubMed/NCBI | |
|
Nishio Y, Koda M, Kamada T, Someya Y, Kadota R, Mannoji C, Miyashita T, Okada S, Okawa A, Moriya H and Yamazaki M: Granulocyte colony-stimulating factor attenuates neuronal death and promotes functional recovery after spinal cord injury in mice. J Neuropathol Exp Neurol. 66:724–731. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Derakhshanrad N, Saberi H, Yekaninejad MS, Joghataei MT and Sheikhrezaei A: Granulocyte-colony stimulating factor administration for neurological improvement in patients with postrehabilitation chronic incomplete traumatic spinal cord injuries: A double-blind randomized controlled clinical trial. J Neurosurg Spine. 29:97–107. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Koda M, Yamazaki M, Furuya T, Hanaoka H and Grp GSS: Phase 3 clinical trial of granulocyte colony stimulating factor-for acute spinal cord injury (G-Spirit Trial). J Neurotrauma. 35:A162–A163. 2018. | |
|
Kitamura K, Iwanami A, Nakamura M, Yamane J, Watanabe K, Suzuki Y, Miyazawa D, Shibata S, Funakoshi H, Miyatake S, et al: Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury. J Neurosci Res. 85:2332–2342. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Ohta Y, Takenaga M, Hamaguchi A, Ootaki M, Takeba Y, Kobayashi T, Watanabe M, Iiri T and Matsumoto N: Isolation of adipose-derived stem/stromal cells from cryopreserved fat tissue and transplantation into rats with spinal cord injury. Int J Mol Sci. 19:19632018. View Article : Google Scholar | |
|
Kitamura K, Fujiyoshi K, Yamane J, Toyota F, Hikishima K, Nomura T, Funakoshi H, Nakamura T, Aoki M, Toyama Y, et al: Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury. PLoS One. 6:e277062011. View Article : Google Scholar : PubMed/NCBI | |
|
Kitamura K, Nagoshi N, Tsuji O, Matsumoto M, Okano H and Nakamura M: Application of hepatocyte growth factor for acute spinal cord Injury: The road from basic studies to human treatment. Int J Mol Sci. 20:10542019. View Article : Google Scholar | |
|
Dergham P, Ellezam B, Essagian C, Avedissian H, Lubell WD and Mckerracher L: Rho signaling pathway targeted to promote spinal cord repair. J Neurosci. 22:6570–6577. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Siddiqui AM, Khazaei M and Fehlings MG: Translating mechanisms of neuroprotection, regeneration, and repair to treatment of spinal cord injury. Prog Brain Res. 218:15–54. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Fehlings MG, Theodore N, Harrop J, Maurais G, Kuntz C, Shaffrey CI, Kwon BK, Chapman J, Yee A, Tighe A and McKerracher L: A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 28:787–796. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Gonzenbach RR, Zoerner B, Schnell L, Weinmann O, Mir AK and Schwab ME: Delayed anti-nogo-a antibody application after spinal cord injury shows progressive loss of responsiveness. J Neurotrauma. 29:567–578. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Xing B, Li H, Wang H, Mukhopadhyay D, Fisher D, Gilpin CJ and Li S: RhoA-inhibiting NSAIDs promote axonal myelination after spinal cord injury. Exp Neurol. 231:247–260. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Iannitti RG, Napolioni V, Oikonomou V, De Luca A, Galosi C, Pariano M, Massi-Benedetti C, Borghi M, Puccetti M, Lucidi V, et al: IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis. Nat Commun. 7:107912016. View Article : Google Scholar : PubMed/NCBI | |
|
Yiu G and He Z: Glial inhibition of CNS axon regeneration. Nat Rev Neurosci. 7:617–627. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Liebscher T, Schnell L, Schnell D, Scholl J, Schneider R, Gullo M, Fouad K, Mir A, Rausch M, Kindler D, et al: Nogo-A antibody improves regeneration and locomotion of spinal cord-injured rats. Ann Neurol. 58:706–719. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Freund P, Wannier T, Schmidlin E, Bloch J, Mir A, Schwab ME and Rouiller EM: Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey. J Comp Neurol. 502:644–659. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Wiessner C, Bareyre FM, Allegrini PR, Mir AK, Frentzel S, Zurini M, Schnell L, Oertle T and Schwab ME: Anti-Nogo-A antibody infusion 24 hours after experimental stroke improved behavioral outcome and corticospinal plasticity in normotensive and spontaneously hypertensive rats. J Cereb Blood Flow Metab. 23:154–165. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Zörner B and Schwab ME: Anti-Nogo on the go: From animal models to a clinical trial. Ann N Y Acad Sci. 1198 (Suppl 1):E22–E34. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Kawakami M: Molecular dissection of cyclosporin A's neuroprotective effect reveals potential therapeutics for ischemic brain injury. Brain Sci. 3:1325–1356. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I and Schreiber SL: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:807–815. 1991. View Article : Google Scholar : PubMed/NCBI | |
|
Sharkey J and Butcher SP: Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature. 371:336–339. 1994. View Article : Google Scholar : PubMed/NCBI | |
|
Arii T, Kamiya T, Arii K, Ueda M, Nito C, Katsura KI and Katayama Y: Neuroprotective effect of immunosuppressant FK506 in transient focal ischemia in rat: Therapeutic time window for FK506 in transient focal ischemia. Neurol Res. 23:755–760. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Gold BG, Densmore V, Shou W, Matzuk MM and Gordon HS: Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506. J Pharmacol Exp Ther. 289:1202–1210. 1999.PubMed/NCBI | |
|
Kang CB, Hong Y, Dhe-Paganon S and Yoon HS: FKBP family proteins: Immunophilins with versatile biological functions. Neurosignals. 16:318–325. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Jones LL, Oudega M, Bunge MB and Tuszynski MH: Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. J Physiol. 533:83–89. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Weissmiller AM and Wu C: Current advances in using neurotrophic factors to treat neurodegenerative disorders. Transl Neurodegener. 1:142012. View Article : Google Scholar : PubMed/NCBI | |
|
Barakat DJ, Gaglani SM, Neravetla SR, Sanchez AR, Andrade CM, Pressman Y, Puzis R, Garg MS, Bunge MB and Pearse DD: Survival, integration, and axon growth support of glia transplanted into the chronically contused spinal cord. Cell Transplant. 14:225–240. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Jiang DJ, Xu CL and Tsang SH: Revolution in gene medicine therapy and genome surgery. Genes. 9:5752018. View Article : Google Scholar | |
|
Boyce VS and Mendell LM: Neurotrophic factors in spinal cord injury. Handb Exp Pharmacol. 220:443–460. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Hodgetts SI and Harvey AR: Neurotrophic factors used to treat spinal cord injury. Vitam Horm. 104:405–457. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Campbell JD and Burnett AL: Neuroprotective and nerve regenerative approaches for treatment of erectile dysfunction after cavernous nerve injury. Int J Mol Sci. 18:17942017. View Article : Google Scholar | |
|
Doll DN, Barr TL and Simpkins JW: Cytokines: Their role in stroke and potential use as biomarkers and therapeutic targets. Aging Dis. 5:294–306. 2014.PubMed/NCBI | |
|
Emsley HC and Tyrrell PJ: Inflammation and infection in clinical stroke. J Cereb Blood Flow Metab. 22:1399–1419. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Huebner EA and Strittmatter SM: Axon regeneration in the peripheral and central nervous systems. Results Probl Cell Differ. 48:339–351. 2009.PubMed/NCBI | |
|
Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, McMahon SB and Bradbury EJ: Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci. 26:10856–10867. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Caggiano AO, Zimber MP, Ganguly A, Blight AR and Gruskin EA: Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord. J Neurotrauma. 22:226–239. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Iaci JF, Vecchione AM, Zimber MP and Caggiano AO: Chondroitin sulfate proteoglycans in spinal cord contusion injury and the effects of chondroitinase treatment. J Neurotrauma. 24:1743–1759. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Iseda T, Okuda T, Kane-Goldsmith N, Mathew M, Ahmed S, Chang YW, Young W and Grumet M: Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion. J Neurotrauma. 25:334–349. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kwok JC, Afshari F, Garcia-Alias G and Fawcett JW: Proteoglycans in the central nervous system: Plasticity, regeneration and their stimulation with chondroitinase ABC. Restor Neurol Neurosci. 26:131–145. 2008.PubMed/NCBI | |
|
Grimpe B and Silver J: A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord. J Neurosci. 24:1393–1397. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
McRae PA and Porter BE: The perineuronal net component of the extracellular matrix in plasticity and epilepsy. Neurochem Int. 61:963–972. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Moon LD, Asher RA, Rhodes KE and Fawcett JW: Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC. Nat Neurosci. 4:465–466. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW and McMahon SB: Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature. 416:636–640. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Wang D, Ichiyama RM, Zhao R, Andrews MR and Fawcett JW: Chondroitinase combined with rehabilitation promotes recovery of forelimb function in rats with chronic spinal cord injury. J Neurosci. 31:9332–9344. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Hu HZ, Granger N, Pai SB, Bellamkonda RV and Jeffery ND: Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury. Brain. 141:1017–1027. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rosenzweig ES, Courtine G, Jindrich DL, Brock JH, Ferguson AR, Strand SC, Nout YS, Roy RR, Miller DM, Beattie MS, et al: Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci. 13:1505–1510. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Lawrence DG and Kuypers HG: The functional organization of the motor system in the monkey. I. The effects of bilateral pyramidal lesions. Brain. 91:1–14. 1968. View Article : Google Scholar : PubMed/NCBI | |
|
Nout YS, Ferguson AR, Strand SC, Moseanko R, Hawbecker S, Zdunowski S, Nielson JL, Roy RR, Zhong H, Rosenzweig ES, et al: Methods for functional assessment after C7 spinal cord hemisection in the rhesus monkey. Neurorehabil Neural Repair. 26:556–569. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Jefferson SC, Tester NJ and Howland DR: Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection. J Neuroscience. 31:5710–5720. 2011. View Article : Google Scholar | |
|
Ma R, Liu X, Clark J, Williams GM and Doi SA: The impact of acupuncture on neurological recovery in spinal cord injury: A systematic review and Meta-analysis. J Neurotrauma. 32:1943–1957. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Zhai Y, Wu J, Zhao S, Zhou J and Liu Z: Acupuncture for chronic urinary retention due to spinal cord injury: A systematic review. Evid Based Complement Alternat Med. 2016:92451862016.PubMed/NCBI | |
|
Dyson-Hudson TA, Kadar P, LaFountaine M, Emmons R, Kirshblum SC, Tulsky D and Komaroff E: Acupuncture for chronic shoulder pain in persons with spinal cord injury: A small-scale clinical trial. Arch Phys Med Rehabil. 88:1276–1283. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Liu F, Zou Y, Liu S, Liu J and Wang T: Electro-acupuncture treatment improves neurological function associated with downregulation of PDGF and inhibition of astrogliosis in rats with spinal cord transection. J Mol Neurosci. 51:629–635. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Tu WZ, Jiang SH, Zhang L, Li SS, Gu PP, He R, Hu J, Gao LP and Sun QS: Electro-acupuncture at Governor Vessel improves neurological function in rats with spinal cord injury. Chin J Integr Med. Jul 31–2017.(Epub ahead of print). doi: 10.1007/s11655-017-2968-9. View Article : Google Scholar | |
|
Lovas J, Tran Y, Middleton J, Bartrop R, Moore N and Craig A: Managing pain and fatigue in people with spinal cord injury: A randomized controlled trial feasibility study examining the efficacy of massage therapy. Spinal Cord. 55:162–166. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Diego MA, Field T, Hernandez-Reif M, Hart S, Brucker B, Field T and Burman I: Spinal cord patients benefit from massage therapy. Int J Neurosci. 112:133–142. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Field T: Massage therapy research review. Complement Ther Clin Pract. 24:19–31. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Moyer CA, Rounds J and Hannum JW: A meta-analysis of massage therapy research. Psychol Bull. 130:3–18. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Field T, Hernandez-Reif M, Diego M, Schanberg S and Kuhn C: Cortisol decreases and serotonin and dopamine increase following massage therapy. Int J Neurosci. 115:1397–1413. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Campeau MP, Gaboriault R, Drapeau M, Van Nguyen T, Roy I, Fortin B, Marois M and Nguyen-Tân PF: Impact of massage therapy on anxiety levels in patients undergoing radiation therapy: Randomized controlled trial. J Soc Integr Oncol. 5:133–138. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Sliwinski MM, Smith R and Wood A: Spinal cord injury rehabilitation patient and physical therapist perspective: A pilot study. Spinal Cord Ser Cases. 2:150362016. View Article : Google Scholar : PubMed/NCBI | |
|
DeSantana JM, Walsh DM, Vance C, Rakel BA and Sluka KA: Effectiveness of transcutaneous electrical nerve stimulation for treatment of hyperalgesia and pain. Curr Rheumatol Rep. 10:492–499. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Gozani SN: Remote analgesic effects of conventional transcutaneous electrical nerve stimulation: A scientific and clinical review with a focus on chronic pain. J Pain Res. 12:3185–3201. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Gibson W, Wand BM and O'Connell NE: Transcutaneous electrical nerve stimulation (TENS) for neuropathic pain in adults. Cochrane Database Syst Rev. 9:CD0119762017.PubMed/NCBI | |
|
Bi X, Lv H, Chen BL, Li X and Wang XQ: Effects of transcutaneous electrical nerve stimulation on pain in patients with spinal cord injury: A randomized controlled trial. J Phys Ther Sci. 27:23–25. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Dailey DL, Rakel BA, Vance CG, Liebano RE, Amrit AS, Bush HM, Lee KS, Lee JE and Sluka KA: Transcutaneous electrical nerve stimulation reduces pain, fatigue and hyperalgesia while restoring central inhibition in primary fibromyalgia. Pain. 154:2554–2562. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Vance CG, Dailey DL, Rakel BA and Sluka KA: Using TENS for pain control: The state of the evidence. Pain Manage. 4:197–209. 2014. View Article : Google Scholar | |
|
Zeb A, Arsh A, Bahadur S and Ilyas SM: Effectiveness of transcutaneous electrical nerve stimulation in management of neuropathic pain in patients with post traumatic incomplete spinal cord injuries. Pak J Med Sci. 34:1177–1180. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hagen EM and Rekand T: Management of neuropathic pain associated with spinal cord injury. Pain Ther. 4:51–65. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Guanziroli E, Cazzaniga M, Colombo L, Basilico S, Legnani G and Molteni F: Assistive powered exoskeleton for complete spinal cord injury: Correlations between walking ability and exoskeleton control. Eur J Phys Rehabil Med. 55:209–216. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Louie DR, Eng JJ and Lam T: Gait speed using powered robotic exoskeletons after spinal cord injury: A systematic review and correlational study. J Neuroeng Rehabil. 12:822015. View Article : Google Scholar : PubMed/NCBI | |
|
Miller LE, Zimmermann AK and Herbert WG: Clinical effectiveness and safety of powered exoskeleton-assisted walking in patients with spinal cord injury: Systematic review with meta-analysis. Med Devices. 9:455–466. 2016. View Article : Google Scholar | |
|
Lajeunesse V, Vincent C, Routhier F, Careau E and Michaud F: Exoskeletons' design and usefulness evidence according to a systematic review of lower limb exoskeletons used for functional mobility by people with spinal cord injury. Disabil Rehabil Assist Technol. 11:535–547. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Nas K, Yazmalar L, Şah V, Aydın A and Öneş K: Rehabilitation of spinal cord injuries. World J Orthopedics. 6:8–16. 2015. View Article : Google Scholar | |
|
Grasmücke D, Zieriacks A, Jansen O, Fisahn C, Sczesny-Kaiser M, Wessling M, Meindl RC, Schildhauer TA and Aach M: Against the odds: What to expect in rehabilitation of chronic spinal cord injury with a neurologically controlled Hybrid Assistive Limb exoskeleton. A subgroup analysis of 55 patients according to age and lesion level. Neurosurg Focus. 42:E152017. View Article : Google Scholar | |
|
Karelis AD, Carvalho LP, Castillo MJ, Gagnon DH and Aubertin-Leheudre M: Effect on body composition and bone mineral density of walking with a robotic exoskeleton in adults with chronic spinal cord injury. J Rehabil Med. 49:84–87. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Gorgey AS, Wade R, Sumrell R, Villadelgado L, Khalil RE and Lavis T: Exoskeleton training may improve level of physical activity after spinal cord injury: A case series. Top Spinal Cord Inj Rehabil. 23:245–255. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Cirnigliaro CM, Myslinski MJ, La Fountaine MF, Kirshblum SC, Forrest GF and Bauman WA: Bone loss at the distal femur and proximal tibia in persons with spinal cord injury: Imaging approaches, risk of fracture, and potential treatment options. Osteoporosis Int. 28:747–765. 2017. View Article : Google Scholar | |
|
Escalona MJ, Brosseau R, Vermette M, Comtois AS, Duclos C, Aubertin-Leheudre M and Gagnon DH: Cardiorespiratory demand and rate of perceived exertion during overground walking with a robotic exoskeleton in long-term manual wheelchair users with chronic spinal cord injury: A cross-sectional study. Ann Phys Rehabil Med. 61:215–223. 2018. View Article : Google Scholar : PubMed/NCBI |
