Hsa_circ_0010957 level is increased and sponges microRNA‑125b in CD4<sup>+</sup> T cells of patients with systemic lupus erythematosus

He,Shan; Du,Hongwei; Wang,Yingfang; Shi,Xiaowei; Zhou,Yongwei

doi:10.3892/mmr.2021.12108

Hsa_circ_0010957 level is increased and sponges microRNA‑125b in CD4⁺ T cells of patients with systemic lupus erythematosus

Authors:
- Shan He
- Hongwei Du
- Yingfang Wang
- Xiaowei Shi
- Yongwei Zhou
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Affiliations: Department of Rheumatology and Immunology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China, Department of Joint Surgery, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang 321000, P.R. China
Published online on: April 20, 2021 https://doi.org/10.3892/mmr.2021.12108
Article Number: 469
Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Systemic lupus erythematosus (SLE) is a severe autoimmune disorder, the pathogenesis of which remains largely unknown. The present study aimed to investigate the role and mechanism of circular RNAs in the etiopathogenesis of SLE. CD4⁺ T cells in patients with SLE expressed higher levels of hsa_circ_0010957 compared with healthy individuals and was a good differentiator of the active from inactive SLE disease. It was also determined that hsa_circ_0010957 mediated microRNA (miR)‑125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)‑18, IL‑6 and IL‑17, which are important factors in the process of SLE. Hsa_circ_0010957 abrogated the proinflammatory effect of IL‑6 via the blockade of STAT3 signaling. In conclusion, increased hsa_circ_0010957 may be involved in SLE pathogenesis via miR‑125b/STAT3 signaling. Hsa_circ_0010957 promises to be a potential biomarker and therapeutic target for SLE.

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