Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)
- Authors:
- Huihui Yao
- Songbing He
-
Affiliations: Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China - Published online on: October 20, 2021 https://doi.org/10.3892/mmr.2021.12506
- Article Number: 866
-
Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
 |
|
Laplane L, Duluc D, Larmonier N, Pradeu T and Bikfalvi A: The multiple layers of the tumor environment. Trends Cancer. 4:802–809. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Elia I and Haigis MC: Metabolites and the tumour microenvironment: From cellular mechanisms to systemic metabolism. Nat Metab. 3:21–32. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen Q, Liu G, Liu S, Su H, Wang Y, Li J and Luo C: Remodeling the tumor microenvironment with emerging nanotherapeutics. Trends Pharmacol Sci. 39:59–74. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Lazar I, Clement E, Attane C, Muller C and Nieto L: A new role for extracellular vesicles: How small vesicles can feed tumors' big appetite. J Lipid Res. 59:1793–1804. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Q, Li B, Li Z, Li J and Sun S and Sun S: Cancer-associated adipocytes: Key players in breast cancer progression. J Hematol Oncol. 12:952019. View Article : Google Scholar : PubMed/NCBI | |
|
Dirat B, Bochet L, Dabek M, Daviaud D, Dauvillier S, Majed B, Wang YY, Meulle A, Salles B, Le Gonidec S, et al: Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 71:2455–2465. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Vaupel H, Schmidberger A and Mayer A: The Warburg effect: Essential part of metabolic reprogramming and central contributor to cancer progression. Int J Radiat Biol. 95:912–919. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Hoxhaj G and Manning BD: The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. Nat Rev Cancer. 20:74–88. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Nieman KM, Romero IL, Van Houten B and Lengyel E: Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta. 1831:1533–1541. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, Flanagan L, Tenniswood MP, Guha C, Lisanti MP, et al: Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene. 22:6408–6423. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Park J, Morley TS, Kim M, Clegg DJ and Scherer PE: Obesity and cancer-mechanisms underlying tumour progression and recurrence. Nat Rev Endocrinol. 10:455–465. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Donohoe CL, Lysaght J, O'sullivan J and Reynolds JV: Emerging concepts linking obesity with the hallmarks of cancer. Trends Endocrinol Metab. 28:46–62. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Kahn CR, Wang G and Lee KY: Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J Clin Invest. 129:3990–4000. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Scheja L and Heeren J: The endocrine function of adipose tissues in health and cardiometabolic disease. Nat Rev Endocrinol. 15:507–524. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Fujisaki K, Fujimoto H, Sangai T, Nagashima T, Sakakibara M, Shiina N, Kuroda M, Aoyagi Y and Miyazaki M: Cancer-mediated adipose reversion promotes cancer cell migration via IL-6 and MCP-1. Breast Cancer Res Treat. 150:255–263. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao C, Wu M, Zeng N, Xiong M, Hu W, Lv W, Yi Y, Zhang Q and Wu Y: Cancer-associated adipocytes: Emerging supporters in breast cancer. J Exp Clin Cancer Res. 39:1562020. View Article : Google Scholar : PubMed/NCBI | |
|
Choi J, Cha YJ and Koo JS: Adipocyte biology in breast cancer: From silent bystander to active facilitator. Prog Lipid Res. 69:11–20. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rybinska I, Agresti R, Trapani A, Tagliabue E and Triulzi T: Adipocytes in breast cancer, the thick and the thin. Cells. 9:5602020. View Article : Google Scholar : PubMed/NCBI | |
|
Pérez-Escuredo J, Van Hée VF, Sboarina M, Falces J, Payen VL, Pellerin L and Sonveaux P: Monocarboxylate transporters in the brain and in cancer. Biochim Biophys Acta. 1863:2481–2497. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yang E, Wang X, Gong Z, Yu M, Wu H and Zhang D: Exosome-mediated metabolic reprogramming: The emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduct Target Ther. 5:2422020. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong X, Wen YA, Fairchild R, Zaytseva YY, Weiss HL, Evers BM and Gao T: Upregulation of CPT1A is essential for the tumor-promoting effect of adipocytes in colon cancer. Cell Death Dis. 11:7362020. View Article : Google Scholar : PubMed/NCBI | |
|
Schlaepfer IR, Rider L, Rodrigues LU, Gijón MA, Pac CT, Romero L, Cimic A, Sirintrapun SJ, Glodé LM, Eckel RH and Cramer SD: Lipid catabolism via CPT1 as a therapeutic target for prostate cancer. Mol Cancer Ther. 13:2361–2371. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Tabuso M, Homer-Vanniasinkam S, Adya R and Arasaradnam RP: Role of tissue microenvironment resident adipocytes in colon cancer. World J Gastroenterol. 23:5829–5835. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ko JH, Um JY, Lee SG, Yang WM, Sethi G and Ahn KS: Conditioned media from adipocytes promote proliferation, migration, and invasion in melanoma and colorectal cancer cells. J Cell Physiol. 234:18249–18261. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Fontana L, Eagon JC, Trujillo ME, Scherer PE and Klein S: Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Diabetes. 56:1010–1013. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Silva C, Rotellar F, Hernández-Lizoain JL, Baixauli J, Valentí V, Pardo F, et al: Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. J Nutr Biochem. 22:634–641. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Peterson JE, Zurakowski D, Italiano JE Jr, Michel LV, Connors S, Oenick M, D'Amato RJ, Klement GL and Folkman J: VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients. Angiogenesis. 15:265–273. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lumeng CN, Deyoung SM, Bodzin JL and Saltiel AR: Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 56:16–23. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA and Chen H: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 112:1821–1830. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Harvey AE, Lashinger LM and Hursting SD: The growing challenge of obesity and cancer: An inflammatory issue. Ann N Y Acad Sci. 1229:45–52. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wagner M, Bjerkvig R, Wiig H, Melero-Martin JM, Lin RZ, Klagsbrun M and Dudley AC: Inflamed tumor-associated adipose tissue is a depot for macrophages that stimulate tumor growth and angiogenesis. Angiogenesis. 15:481–495. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Amor S, Iglesias-de la Cruz MC, Ferrero E, García-Villar O, Barrios V, Fernandez N, Monge L, García-Villalón AL and Granado M: Peritumoral adipose tissue as a source of inflammatory and angiogenic factors in colorectal cancer. Int J Colorectal Dis. 31:365–375. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ye P, Xi Y, Huang Z and Xu P: Linking obesity with colorectal cancer: Epidemiology and mechanistic insights. Cancers (Basel). 12:14082020. View Article : Google Scholar : PubMed/NCBI | |
|
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, et al: Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling. Cancer Res. 74:6806–6819. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
D'Esposito V, Liguoro D, Ambrosio MR, Collina F, Cantile M, Spinelli R, Raciti GA, Miele C, Valentino R, Campiglia P, et al: Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5. Oncotarget. 7:24495–24509. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
De Palma M, Biziato D and Petrova TV: Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 17:457–474. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang YY, Attané C, Milhas D, Dirat B, Dauvillier S, Guerard A, Gilhodes J, Lazar I, Alet N, Laurent V, et al: Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells. JCI Insight. 2:e874892017. View Article : Google Scholar : PubMed/NCBI | |
|
Attane C, Milhas D, Hoy AJ and Muller C: Metabolic remodeling induced by adipocytes: A new Achille heels in invasive breast cancer? Curr Med Chem. 27:3984–4001. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Bussard KM, Mutkus L, Stumpf K, Gomez-Manzano C and Marini FC: Tumor associated stromal cells as key contributors to the tumor microenvironment. Breast Cancer Res. 18:842016. View Article : Google Scholar : PubMed/NCBI | |
|
Lengyel E: Ovarian cancer development and metastasis. Am J Pathol. 177:1053–1064. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
John B, Naczki C, Patel C, Ghoneum A, Qasem S, Salih Z and Said N: Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC. Oncogene. 38:4366–4383. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Mukherjee A, Chiang CY, Daifotis HA, Nieman KM, Fahrmann JF, Lastra RR, Romero IL, Fiehn O and Lengyel E: Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance. Cancer Res. 80:1748–1761. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Sun C, Li X, Guo E, Li N, Zhou B, Lu H, Huang J, Xia M, Shan W, Wang B, et al: MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis. Oncogene. 39:1681–1695. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, et al: Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 17:1498–1503. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Coburn CT, Knapp FF Jr, Febbraio M, Beets AL, Silverstein RL and Abumrad NA: Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J Biol Chem. 275:32523–32529. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Au Yeung CL, Co NN, Tsuruga T, Yeung TL, Kwan SY, Leung CS, Li Y, Lu ES, Kwan K, Wong KK, et al: Exosomal transfer of stroma-derived miR21 confers paclitaxel resistance in ovarian cancer cells through targeting APAF1. Nat Commun. 7:111502016. View Article : Google Scholar : PubMed/NCBI | |
|
Renehan AG, Tyson M, Egger M, Heller RF and Zwahlen M: Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies. Lancet. 371:569–578. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Sun X, Wang M, Wang M, Yu X, Guo J, Sun T, Li X, Yao L, Dong H and Xu Y: Metabolic reprogramming in triple-negative breast cancer. Front Oncol. 10:4282020. View Article : Google Scholar : PubMed/NCBI | |
|
Santander AM, Lopez-Ocejo O, Casas O, Agostini T, Sanchez L, Lamas-Basulto E, Carrio R, Cleary MP, Gonzalez-Perez RR and Torroella-Kouri M: Paracrine interactions between adipocytes and tumor cells recruit and modify macrophages to the mammary tumor microenvironment: The role of obesity and inflammation in breast adipose tissue. Cancers (Basel). 7:143–178. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Cairns RA, Harris IS and Mak TW: Regulation of cancer cell metabolism. Nat Rev Cancer. 11:85–95. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Warburg O: On the origin of cancer cells. Science. 123:309–314. 1956. View Article : Google Scholar : PubMed/NCBI | |
|
Vander Heiden MG, Cantley LC and Thompson CB: Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science. 324:1029–1033. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Corn KC, Windham MA and Rafat M: Lipids in the tumor microenvironment: From cancer progression to treatment. Prog Lipid Res. 80:1010552020. View Article : Google Scholar : PubMed/NCBI | |
|
Pallegar NK and Christian SL: Adipocytes in the tumour microenvironment. Adv Exp Med Biol. 1234:1–13. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Dias AS, Almeida CR, Helguero LA and Duarte IF: Metabolic crosstalk in the breast cancer microenvironment. Eur J Cancer. 121:154–171. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Balaban S, Shearer RF, Lee LS, van Geldermalsen M, Schreuder M, Shtein HC, Cairns R, Thomas KC, Fazakerley DJ, Grewal T, et al: Adipocyte lipolysis links obesity to breast cancer growth: Adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab. 5:12017. View Article : Google Scholar : PubMed/NCBI | |
|
Yang D, Li Y, Xing L, Tan Y, Sun J, Zeng B, Xiang T, Tan J, Ren G and Wang Y: Utilization of adipocyte-derived lipids and enhanced intracellular trafficking of fatty acids contribute to breast cancer progression. Cell Commun Signal. 16:322018. View Article : Google Scholar : PubMed/NCBI | |
|
Zaoui M, Morel M, Ferrand N, Fellahi S, Bastard JP, Lamazière A, Larsen AK, Béréziat V, Atlan M and Sabbah M: Breast-associated adipocytes secretome induce fatty acid uptake and invasiveness in breast cancer cells via CD36 independently of body mass index, menopausal status and mammary density. Cancers (Basel). 11:20122019. View Article : Google Scholar : PubMed/NCBI | |
|
Ladanyi A, Mukherjee A, Kenny HA, Johnson A, Mitra AK, Sundaresan S, Nieman KM, Pascual G, Benitah SA, Montag A, et al: Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis. Oncogene. 37:2285–2301. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang M, Di Martino JS, Bowman RL, Campbell NR, Baksh SC, Simon-Vermot T, Kim IS, Haldeman P, Mondal C, Yong-Gonzales V, et al: Adipocyte-derived lipids mediate melanoma progression via FATP proteins. Cancer Discov. 8:1006–1025. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Lopes-Coelho F, Andre S, Felix A and Serpa J: Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids. Mol Cell Endocrinol. 462:93–106. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Wang T, Fahrmann JF, Lee H, Li YJ, Tripathi SC, Yue C, Zhang C, Lifshitz V, Song J, Yuan Y, et al: JAK/STAT3-regulated fatty acid β-oxidation is critical for breast cancer stem cell self-renewal and chemoresistance. Cell Metab. 27:136–150.e5. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang C, Yue C, Herrmann A, Song J, Egelston C, Wang T, Zhang Z, Li W, Lee H, Aftabizadeh M, et al: STAT3 activation-induced fatty acid oxidation in CD8+ T effector cells is critical for obesity-promoted breast tumor growth. Cell Metab. 31:148–161.e5. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, et al: Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction. Cell Metab. 20:368–375. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Ye H, Adane B, Khan N, Sullivan T, Minhajuddin M, Gasparetto M, Stevens B, Pei S, Balys M, Ashton JM, et al: Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche. Cell Stem Cell. 19:23–37. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, et al: A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discov. 9:617–627. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Benesch MG, Tang X, Maeda T, Ohhata A, Zhao YY, Kok BP, Dewald J, Hitt M, Curtis JM, McMullen TP and Brindley DN: Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice. FASEB J. 28:2655–2666. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yang L, Yu X and Yang Y: Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms. Endocr Connect. 7:1299–1307. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Azare J, Doane A, Leslie K, Chang Q, Berishaj M, Nnoli J, Mark K, Al-Ahmadie H, Gerald W, Hassimi M, et al: Stat3 mediates expression of autotaxin in breast cancer. PLoS One. 6:e278512011. View Article : Google Scholar : PubMed/NCBI | |
|
Schmid R, Wolf K, Robering JW, Strauß S, Strissel PL, Strick R, Rübner M, Fasching PA, Horch RE, Kremer AE, et al: ADSCs and adipocytes are the main producers in the autotaxin-lysophosphatidic acid axis of breast cancer and healthy mammary tissue in vitro. BMC Cancer. 18:12732018. View Article : Google Scholar : PubMed/NCBI | |
|
Corbet C and Feron O: Emerging roles of lipid metabolism in cancer progression. Curr Opin Clin Nutr Metab Care. 20:254–260. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, et al: Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. 541:41–45. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wculek SK and Malanchi I: Neutrophils support lung colonization of metastasis-initiating breast cancer cells. Nature. 528:413–417. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Poltavets V, Kochetkova M, Pitson SM and Samuel MS: The role of the extracellular matrix and its molecular and cellular regulators in cancer cell plasticity. Front Oncol. 8:4312018. View Article : Google Scholar : PubMed/NCBI | |
|
Bacac M and Stamenkovic I: Metastatic cancer cell. Annu Rev Pathol. 3:221–247. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Quail DF and Joyce JA: Microenvironmental regulation of tumor progression and metastasis. Nat Med. 19:1423–1437. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Tsai JH and Yang J: Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev. 27:2192–2206. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Ribeiro RJ, Monteiro CP, Cunha VF, Azevedo AS, Oliveira MJ, Monteiro R, Fraga AM, Príncipe P, Lobato C, Lobo F, et al: Tumor cell-educated periprostatic adipose tissue acquires an aggressive cancer-promoting secretory profile. Cell Physiol Biochem. 29:233–240. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Lee SG, Kim JS, Kim HJ, Schlaepfer DD, Kim IS and Nam JO: Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI. Sci Rep. 11:96442021. View Article : Google Scholar : PubMed/NCBI | |
|
Campo-Verde-Arbocco F, López-Laur JD, Romeo LR, Giorlando N, Bruna FA, Contador DE, López-Fontana G, Santiano FE, Sasso CV, Zyla LE, et al: Human renal adipose tissue induces the invasion and progression of renal cell carcinoma. Oncotarget. 8:94223–94234. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Iyengar P, Espina V, Williams TW, Lin Y, Berry D, Jelicks LA, Lee H, Temple K, Graves R, Pollard J, et al: Adipocyte-derived collagen VI affects early mammary tumor progression in vivo, demonstrating a critical interaction in the tumor/stroma microenvironment. J Clin Invest. 115:1163–1176. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Bochet L, Meulle A, Imbert S, Salles B, Valet P and Muller C: Cancer-associated adipocytes promotes breast tumor radioresistance. Biochem Biophys Res Commun. 411:102–106. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Tennant DA, Durán RV and Gottlieb E: Targeting metabolic transformation for cancer therapy. Nat Rev Cancer. 10:267–277. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Ueda S, Saeki T, Osaki A, Yamane T and Kuji I: Bevacizumab induces acute hypoxia and cancer progression in patients with refractory breast cancer: Multimodal functional imaging and multiplex cytokine analysis. Clin Cancer Res. 23:5769–5778. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Levitsky A, Brismar K, Hafström I, Hambardzumyan K, Lourdudoss C, van Vollenhoven RF and Saevarsdottir S: Obesity is a strong predictor of worse clinical outcomes and treatment responses in early rheumatoid arthritis: Results from the SWEFOT trial. RMD Open. 3:e0004582017. View Article : Google Scholar : PubMed/NCBI | |
|
Castillo JJ, Mulkey F, Geyer S, Kolitz JE, Blum W, Powell BL, George SL, Larson RA and Stone RM: Relationship between obesity and clinical outcome in adults with acute myeloid leukemia: A pooled analysis from four CALGB (alliance) clinical trials. Am J Hematol. 91:199–204. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Laurent V, Guérard A, Mazerolles C, Le Gonidec S, Toulet A, Nieto L, Zaidi F, Majed B, Garandeau D, Socrier Y, et al: Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity. Nat Commun. 7:102302016. View Article : Google Scholar : PubMed/NCBI | |
|
Osman MA and Hennessy BT: Obesity correlation with metastases development and response to first-line metastatic chemotherapy in breast cancer. Clin Med Insights Oncol. 9:105–112. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Engin A: Obesity-associated breast cancer: Analysis of risk factors. Adv Exp Med Biol. 960:571–606. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Cao Y: Tumor angiogenesis and molecular targets for therapy. Front Biosci (Landmark Ed). 14:3962–3973. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Iwamoto H, Abe M, Yang Y, Cui D, Seki T, Nakamura M, Hosaka K, Lim S, Wu J, He X, et al: Cancer lipid metabolism confers antiangiogenic drug resistance. Cell Metab. 28:104–117.e5. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hedlund EM, Yang X, Zhang Y, Yang Y, Shibuya M, Zhong W, Sun B, Liu Y, Hosaka K and Cao Y: Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs. Proc Natl Acad Sci USA. 110:654–659. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Honek J, Seki T, Iwamoto H, Fischer C, Li J, Lim S, Samani NJ, Zang J and Cao Y: Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues. Proc Natl Acad Sci USA. 111:14906–14911. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Zhang Y, Iwamoto H, Hosaka K, Seki T, Andersson P, Lim S, Fischer C, Nakamura M, Abe M, et al: Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism. Nat Commun. 7:126802016. View Article : Google Scholar : PubMed/NCBI | |
|
Levine AJ and Puzio-Kuter AM: The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science. 330:1340–1344. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat VB, Bhowmik SK, Gupta V, Arora K, et al: Fatty acid oxidation-driven src links mitochondrial energy reprogramming and oncogenic properties in triple-negative breast cancer. Cell Rep. 14:2154–2165. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Trédan O, Lacroix-Triki M, Guiu S, Mouret-Reynier MA, Barrière J, Bidard FC, Braccini AL, Mir O, Villanueva C and Barthélémy P: Angiogenesis and tumor microenvironment: Bevacizumab in the breast cancer model. Target Oncol. 10:189–198. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, et al: Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. Sci Transl Med. 10:eaag09452018. View Article : Google Scholar : PubMed/NCBI | |
|
Casanovas O, Hicklin DJ, Bergers G and Hanahan D: Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell. 8:299–309. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Dimou NL, Papadimitriou N, Mariosa D, Johansson M, Brennan P, Peters U, Chanock SJ, Purdue M, Bishop DT, Gago-Dominquez M, et al: Circulating adipokine concentrations and risk of five obesity-related cancers: A mendelian randomization study. Int J Cancer. 148:1625–1636. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Cha YJ, Kim ES and Koo JS: Tumor-associated macrophages and crown-like structures in adipose tissue in breast cancer. Breast Cancer Res Treat. 170:15–25. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R and Weinberg RA: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 449:557–563. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Lee JO, Kim N, Lee HJ, Lee YW, Kim SJ, Park SH and Kim HS: Resistin, a fat-derived secretory factor, promotes metastasis of MDA-MB-231 human breast cancer cells through ERM activation. Sci Rep. 6:189232016. View Article : Google Scholar : PubMed/NCBI | |
|
Xiong Y, Russell DL, McDonald LT, Cowart LA and LaRue AC: Hematopoietic stem cell-derived adipocytes promote tumor growth and cancer cell migration. Int J Cancer Res Mol Mech. 3:102017.PubMed/NCBI | |
|
Wang C, Gao C, Meng K, Qiao H and Wang Y: Human adipocytes stimulate invasion of breast cancer MCF-7 cells by secreting IGFBP-2. PLoS One. 10:e01193482015. View Article : Google Scholar : PubMed/NCBI | |
|
Sánchez-Jiménez F, Pérez-Pérez A, de la Cruz-Merino L and Sánchez-Margalet V: Obesity and breast cancer: Role of leptin. Front Oncol. 9:5962019. View Article : Google Scholar : PubMed/NCBI | |
|
Ando S, Barone I, Giordano C, Bonofiglio D and Catalano S: The multifaceted mechanism of leptin signaling within tumor microenvironment in driving breast cancer growth and progression. Front Oncol. 4:3402014.PubMed/NCBI | |
|
Gnerlich JL, Yao KA, Fitchev PS, Goldschmidt RA, Bond MC, Cornwell M and Crawford SE: Peritumoral expression of adipokines and fatty acids in breast cancer. Ann Surg Oncol. 20 (Suppl 3):S731–S738. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Okumura M, Yamamoto M, Sakuma H, Kojima T, Maruyama T, Jamali M, Cooper DR and Yasuda K: Leptin and high glucose stimulate cell proliferation in MCF-7 human breast cancer cells: Reciprocal involvement of PKC-alpha and PPAR expression. Biochim Biophys Acta. 1592:107–116. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou W, Guo S and Gonzalez-Perez RR: Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling. Br J Cancer. 104:128–137. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Wei L, Li K, Pang X, Guo B, Su M, Huang Y, Wang N, Ji F, Zhong C, Yang J, et al: Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2. J Exp Clin Cancer Res. 35:1662016. View Article : Google Scholar : PubMed/NCBI | |
|
Juárez-Cruz JC, Zuñiga-Eulogio MD, Olea-Flores M, Castañeda-Saucedo E, Mendoza-Catalán MÁ, Ortuño-Pineda C, Moreno-Godínez ME, Villegas-Comonfort S, Padilla-Benavides T and Navarro-Tito N: Leptin induces cell migration and invasion in a FAK-Src-dependent manner in breast cancer cells. Endocr Connect. 8:1539–1552. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Endo H, Hosono K, Uchiyama T, Sakai E, Sugiyama M, Takahashi H, Nakajima N, Wada K, Takeda K, Nakagama H and Nakajima A: Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis. Gut. 60:1363–1371. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
He JY, Wei XH, Li SJ, Liu Y, Hu HL, Li ZZ, Kuang XH, Wang L, Shi X, Yuan ST and Sun L: Adipocyte-derived IL-6 and leptin promote breast cancer metastasis via upregulation of Lysyl Hydroxylase-2 expression. Cell Commun Signal. 16:1002018. View Article : Google Scholar : PubMed/NCBI | |
|
Li K, Wei L, Huang Y, Wu Y, Su M, Pang X, Wang N, Ji F, Zhong C and Chen T: Leptin promotes breast cancer cell migration and invasion via IL-18 expression and secretion. Int J Oncol. 48:2479–2487. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Maroni P: Leptin, adiponectin, and Sam68 in bone metastasis from breast cancer. Int J Mol Sci. 21:10512020. View Article : Google Scholar : PubMed/NCBI | |
|
Sultana R, Kataki AC, Borthakur BB, Basumatary TK and Bose S: Imbalance in leptin-adiponectin levels and leptin receptor expression as chief contributors to triple negative breast cancer progression in Northeast India. Gene. 621:51–58. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chung SJ, Nagaraju GP, Nagalingam A, Muniraj N, Kuppusamy P, Walker A, Woo J, Győrffy B, Gabrielson E, Saxena NK and Sharma D: ADIPOQ/adiponectin induces cytotoxic autophagy in breast cancer cells through STK11/LKB1-mediated activation of the AMPK-ULK1 axis. Autophagy. 13:1386–1403. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Q, Li B and Sun S and Sun S: Unraveling adipocytes and cancer links: Is there a role for senescence? Front Cell Dev Biol. 8:2822020. View Article : Google Scholar : PubMed/NCBI | |
|
Hardie DG: AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy. Nat Rev Mol Cell Biol. 8:774–785. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kim J, Kundu M, Viollet B and Guan KL: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol. 13:132–141. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Theriau CF, Sauvé OS, Beaudoin MS, Wright DC and Connor MK: Proliferative endocrine effects of adipose tissue from obese animals on MCF7 cells are ameliorated by resveratrol supplementation. PLoS One. 12:e01838972017. View Article : Google Scholar : PubMed/NCBI | |
|
Tae CH, Kim SE, Jung SA, Joo YH, Shim KN, Jung HK, Kim TH, Cho MS, Kim KH and Kim JS: Involvement of adiponectin in early stage of colorectal carcinogenesis. BMC Cancer. 14:8112014. View Article : Google Scholar : PubMed/NCBI | |
|
Li W, Saud SM, Young MR, Chen G and Hua B: Targeting AMPK for cancer prevention and treatment. Oncotarget. 6:7365–7378. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Park SY, Kim D and Kee SH: Metformin-activated AMPK regulates β-catenin to reduce cell proliferation in colon carcinoma RKO cells. Oncol Lett. 17:2695–2702. 2019.PubMed/NCBI | |
|
Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, et al: Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Sci Signal. 9:ra1092016. View Article : Google Scholar : PubMed/NCBI | |
|
Waldner MJ, Foersch S and Neurath MF: Interleukin-6-a key regulator of colorectal cancer development. Int J Biol Sci. 8:1248–1253. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Semaan J, Pinon A, Rioux B, Hassan L, Limami Y, Pouget C, Fagnère C, Sol V, Diab-Assaf M, Simon A and Liagre B: Resistance to 3-HTMC-induced apoptosis through activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 pathways in human HT-29 and HCT116 colorectal cancer cells. J Cell Biochem. 117:2875–2885. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yoshimura T: The chemokine MCP-1 (CCL2) in the host interaction with cancer: A foe or ally? Cell Mol Immunol. 15:335–345. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Bonapace L, Coissieux MM, Wyckoff J, Mertz KD, Varga Z, Junt T and Bentires-Alj M: Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature. 515:130–133. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Tsuyada A, Chow A, Wu J, Somlo G, Chu P, Loera S, Luu T, Li AX, Wu X, Ye W, et al: CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res. 72:2768–2779. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Saji H, Koike M, Yamori T, Saji S, Seiki M, Matsushima K and Toi M: Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer. 92:1085–1091. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Dommel S and Blüher M: Does C-C motif chemokine ligand 2 (CCL2) link obesity to a pro-inflammatory state? Int J Mol Sci. 22:15002021. View Article : Google Scholar : PubMed/NCBI | |
|
Faria SS, Corrêa LH, Heyn GS, de Sant'Ana LP, Almeida RDN and Magalhães KG: Obesity and breast cancer: The role of crown-like structures in breast adipose tissue in tumor progression, prognosis, and therapy. J Breast Cancer. 23:233–245. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Hsieh CC and Huang YS: Aspirin breaks the crosstalk between 3T3-L1 adipocytes and 4T1 breast cancer cells by regulating cytokine production. PLoS One. 11:e01471612016. View Article : Google Scholar : PubMed/NCBI | |
|
Kuziel G, Thompson V, D'Amato JV and Arendt LM: Stromal CCL2 signaling promotes mammary tumor fibrosis through recruitment of myeloid-lineage cells. Cancers (Basel). 12:20832020. View Article : Google Scholar : PubMed/NCBI | |
|
Kranjc MK, Novak M, Pestell RG and Lah TT: Cytokine CCL5 and receptor CCR5 axis in glioblastoma multiforme. Radiol Oncol. 53:397–406. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Suárez-Nájera LE, Chanona-Pérez JJ, Valdivia-Flores A, Marrero-Rodríguez D, Salcedo-Vargas M, García-Ruiz DI and Castro-Reyes MA: Morphometric study of adipocytes on breast cancer by means of photonic microscopy and image analysis. Microsc Res Tech. 81:240–249. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zazo S, González-Alonso P, Martín-Aparicio E, Chamizo C, Luque M, Sanz-Álvarez M, Mínguez P, Gómez-López G, Cristóbal I, Caramés C, et al: Autocrine CCL5 effect mediates trastuzumab resistance by ERK pathway activation in HER2-positive breast cancer. Mol Cancer Ther. 19:1696–1707. 2020.PubMed/NCBI | |
|
Song X, Zhou X, Qin Y, Yang J, Wang Y, Sun Z, Yu K, Zhang S and Liu S: Emodin inhibits epithelial-mesenchymal transition and metastasis of triple negative breast cancer via antagonism of CC-chemokine ligand 5 secreted from adipocytes. Int J Mol Med. 42:579–588. 2018.PubMed/NCBI | |
|
Gao D, Rahbar R and Fish EN: CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells. Open Biol. 6:1601222016. View Article : Google Scholar : PubMed/NCBI | |
|
Sax MJ, Gasch C, Athota VR, Freeman R, Rasighaemi P, Westcott DE, Day CJ, Nikolic I, Elsworth B, Wei M, et al: Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer. Oncotarget. 7:85437–85449. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Velasco-Velazquez M and Pestell RG: The CCL5/CCR5 axis promotes metastasis in basal breast cancer. Oncoimmunology. 2:e236602013. View Article : Google Scholar : PubMed/NCBI | |
|
Velasco-Velázquez M, Jiao X, De La Fuente M, Pestell TG, Ertel A, Lisanti MP and Pestell RG: CCR5 antagonist blocks metastasis of basal breast cancer cells. Cancer Res. 72:3839–3850. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kim EJ, Kim YK, Kim S, Kim JE, Tian YD, Doh EJ, Lee DH and Chung JH: Adipochemokines induced by ultraviolet irradiation contribute to impaired fat metabolism in subcutaneous fat cells. Br J Dermatol. 178:492–501. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Keophiphath M, Rouault C, Divoux A, Clement K and Lacasa D: CCL5 promotes macrophage recruitment and survival in human adipose tissue. Arterioscler Thromb Vasc Biol. 30:39–45. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Shao L, Feng B, Zhang Y, Zhou H, Ji W and Min W: The role of adipose-derived inflammatory cytokines in type 1 diabetes. Adipocyte. 5:270–274. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Brett E, Sauter M, Timmins É, Azimzadeh O, Rosemann M, Merl-Pham J, Hauck SM, Nelson PJ, Becker KF, Schunn I, et al: Oncogenic linear collagen VI of invasive breast cancer is induced by CCL5. J Clin Med. 9:9912020. View Article : Google Scholar : PubMed/NCBI | |
|
Guo Y, Xu F, Lu T, Duan Z and Zhang Z: Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev. 38:904–910. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Kim HS, Jung M, Choi SK, Woo J, Piao YJ, Hwang EH, Kim H, Kim SJ and Moon WK: IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression. J Exp Clin Cancer Res. 37:2002018. View Article : Google Scholar : PubMed/NCBI | |
|
Lee J, Hong BS, Ryu HS, Lee HB, Lee M, Park IA, Kim J, Han W, Noh DY and Moon HG: Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism. PLoS One. 12:e01741262017. View Article : Google Scholar : PubMed/NCBI | |
|
Bachelot T, Ray-Coquard I, Menetrier-Caux C, Rastkha M, Duc A and Blay JY: Prognostic value of serum levels of interleukin 6 and of serum and plasma levels of vascular endothelial growth factor in hormone-refractory metastatic breast cancer patients. Br J Cancer. 88:1721–1726. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Deng T, Lyon CJ, Bergin S, Caligiuri MA and Hsueh WA: Obesity, inflammation, and cancer. Annu Rev Pathol. 11:421–449. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Liu S, Lee JS, Jie C, Park MH, Iwakura Y, Patel Y, Soni M, Reisman D and Chen H: HER2 overexpression triggers an IL1α proinflammatory circuit to drive tumorigenesis and promote chemotherapy resistance. Cancer Res. 78:2040–2051. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Banerjee K and Resat H: Constitutive activation of STAT3 in breast cancer cells: A review. Int J Cancer. 138:2570–2578. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Nickel A, Blücher C, Kadri OA, Schwagarus N, Müller S, Schaab M, Thiery J, Burkhardt R and Stadler SC: Adipocytes induce distinct gene expression profiles in mammary tumor cells and enhance inflammatory signaling in invasive breast cancer cells. Sci Rep. 8:94822018. View Article : Google Scholar : PubMed/NCBI | |
|
Gyamfi J, Lee YH, Eom M and Choi J: Interleukin-6/STAT3 signalling regulates adipocyte induced epithelial-mesenchymal transition in breast cancer cells. Sci Rep. 8:88592018. View Article : Google Scholar : PubMed/NCBI | |
|
Jin K, Pandey NB and Popel AS: Simultaneous blockade of IL-6 and CCL5 signaling for synergistic inhibition of triple-negative breast cancer growth and metastasis. Breast Cancer Res. 20:542018. View Article : Google Scholar : PubMed/NCBI | |
|
Guo C, Chen Y, Gao W, Chang A, Ye Y, Shen W, Luo Y, Yang S, Sun P, Xiang R and Li N: Liposomal nanoparticles carrying anti-IL6R antibody to the tumour microenvironment inhibit metastasis in two molecular subtypes of breast cancer mouse models. Theranostics. 7:775–788. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Gyamfi J, Lee YH, Min BS and Choi J: Niclosamide reverses adipocyte induced epithelial-mesenchymal transition in breast cancer cells via suppression of the interleukin-6/STAT3 signalling axis. Sci Rep. 9:113362019. View Article : Google Scholar : PubMed/NCBI |
