![Open Access](/resources/images/iconopenaccess.png)
Shuttling of cellular proteins between the plasma membrane and nucleus (Review)
- Authors:
- Hua-Chuan Zheng
- Hua-Mao Jiang
-
Affiliations: Department of Oncology, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, P.R. China, Department of Urology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China - Published online on: November 10, 2021 https://doi.org/10.3892/mmr.2021.12530
- Article Number: 14
-
Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Alber AB and Suter DM: Dynamics of protein synthesis and degradation through the cell cycle. Cell Cycle. 18:784–794. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Soniat M and Chook YM: Nuclear localization signals for four distinct karyopherin-beta nuclear import systems. Biochem J. 468:353–362. 2015. View Article : Google Scholar : PubMed/NCBI |
|
Meinema AC, Laba JK, Hapsari RA, Otten R, Mulder FA, Kralt A, van den Bogaart G, Lusk CP, Poolman B and Veenhoff LM: Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science. 333:90–93. 2011. View Article : Google Scholar : PubMed/NCBI |
|
Borlido J, Zecchini V and Mills IG: Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis. Traffic. 10:1209–1220. 2009. View Article : Google Scholar : PubMed/NCBI |
|
Moroianu J: Nuclear import and export pathways. J Cell Biochem Suppl 32-33. S76–S83. 1999. View Article : Google Scholar : PubMed/NCBI |
|
Etienne-Manneville S and Lammerding J: Connecting the plasma membrane to the nucleus by intermediate filaments. Mol Biol Cell. 28:695–696. 2017. View Article : Google Scholar : PubMed/NCBI |
|
Pan D and Lin X: Epithelial growth factor receptor-activated nuclear factor κB signaling and its role in epithelial growth factor receptor-associated tumors. Cancer J. 19:461–467. 2013. View Article : Google Scholar : PubMed/NCBI |
|
Packham S, Lin Y, Zhao Z, Warsito D, Rutishauser D and Larsson O: The nucleus-localized epidermal growth factor receptor is SUMOylated. Biochemistry. 54:5157–5166. 2015. View Article : Google Scholar : PubMed/NCBI |
|
De Angelis Campos AC, Rodrigues MA, de Andrade C, de Goes AM, Nathanson MH and Gomes DA: Epidermal growth factor receptors destined for the nucleus are internalized via a clathrin-dependent pathway. Biochem Biophys Res Commun. 412:341–346. 2011. View Article : Google Scholar : PubMed/NCBI |
|
Reif R, Adawy A, Vartak N, Schröder J, Günther G, Ghallab A, Schmidt M, Schormann W and Hengstler JG: Activated ErbB3 translocates to the nucleus via clathrin-independent endocytosis, which is associated with proliferating cells. J Biol Chem. 291:3837–3847. 2016. View Article : Google Scholar : PubMed/NCBI |
|
Gururaj AE, Gibson L, Panchabhai S, Bai M, Manyam G, Lu Y, Latha K, Rojas ML, Hwang Y, Liang S and Bogler O: Access to the nucleus and functional association with c-Myc is required for the full oncogenic potential of ΔEGFR/EGFRvIII. J Biol Chem. 288:3428–3438. 2013. View Article : Google Scholar : PubMed/NCBI |
|
Bryant DM and Stow JL: Nuclear translocation of cell-surface receptors: Lessons from fibroblast growth factor. Traffic. 6:947–954. 2005. View Article : Google Scholar : PubMed/NCBI |
|
Tuzon CT, Rigueur D and Merrill AE: Nuclear fibroblast growth factor receptor signaling in skeletal development and disease. Curr Osteoporos Rep. 17:138–146. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Zhou L, Yao LT, Liang ZY, Zhou WX, You L, Shao QQ, Huang S, Guo JC and Zhao YP: Nuclear translocation of fibroblast growth factor receptor 3 and its significance in pancreatic cancer. Int J Clin Exp Pathol. 8:14640–14648. 2015.PubMed/NCBI |
|
Narla ST, Klejbor I, Birkaya B, Lee YW, Morys J, Stachowiak EK, Prokop D, Bencherif M and Stachowiak MK: Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by α7 nicotinic receptor agonist. Stem Cells Transl Med. 2:776–788. 2013. View Article : Google Scholar : PubMed/NCBI |
|
Zhang Y, Xia M, Jin K, Wang S, Wei H, Fan C, Wu Y, Li X, Li X, Li G, et al: Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities. Mol Cancer. 17:452018. View Article : Google Scholar : PubMed/NCBI |
|
Gomes DA, Rodrigues MA, Leite MF, Gomez MV, Varnai P, Balla T, Bennett AM and Nathanson MH: c-Met must translocate to the nucleus to initiate calcium signals. J Biol Chem. 283:4344–4351. 2008. View Article : Google Scholar : PubMed/NCBI |
|
Chen Y, Huang L, Qi X and Chen C: Insulin receptor trafficking: Consequences for insulin sensitivity and diabetes. Int J Mol Sci. 20:50072019. View Article : Google Scholar : PubMed/NCBI |
|
Kesten D, Horovitz-Fried M, Brutman-Barazani T and Sampson SR: Insulin-induced translocation of IR to the nucleus in insulin responsive cells requires a nuclear translocation sequence. Biochim Biophys Acta Mol Cell Res. 1865:551–559. 2018. View Article : Google Scholar : PubMed/NCBI |
|
Kabuta T, Hakuno F, Asano T and Takahashi S: Insulin receptor substrate-3 functions as transcriptional activator in the nucleus. J Biol Chem. 277:6846–6851. 2002. View Article : Google Scholar : PubMed/NCBI |
|
Kim JW, Kim HS, Kim SD and Park JY: Insulin phosphorylates tyrosine residue 464 of tub and translocates tubby into the nucleus in HIRcB cells. Endocrinol Metab (Seoul). 29:163–168. 2014. View Article : Google Scholar : PubMed/NCBI |
|
Guégan JP, Ginestier C, Charafe-Jauffret E, Ducret T, Quignard JF, Vacher P and Legembre P: CD95/Fas and metastatic disease: What does not kill you makes you stronger. Semin Cancer Biol. 60:121–131. 2020. View Article : Google Scholar : PubMed/NCBI |
|
Garofalo T, Tinari A, Matarrese P, Giammarioli AM, Manganelli V, Ciarlo L, Misasi R, Sorice M and Malorni W: Do mitochondria act as ‘cargo boats’ in the journey of GD3 to the nucleus during apoptosis? FEBS Lett. 581:3899–3903. 2007. View Article : Google Scholar : PubMed/NCBI |
|
Sheikh MS and Huang Y: The FADD is going nuclear. Cell Cycle. 2:346–347. 2003. View Article : Google Scholar : PubMed/NCBI |
|
Amarante-Mendes GP and Griffith TS: Therapeutic applications of TRAIL receptor agonists in cancer and beyond. Pharmacol Ther. 155:117–131. 2015. View Article : Google Scholar : PubMed/NCBI |
|
Mert U, Adawy A, Scharff E, Teichmann P, Willms A, Haselmann V, Colmorgen C, Lemke J, von Karstedt S, Fritsch J and Trauzold A: TRAIL induces nuclear translocation and chromatin localization of TRAIL death receptors. Cancer (Basel). 11:11672019. View Article : Google Scholar |
|
Adlere I, Caspar B, Arimont M, Dekkers S, Visser K, Stuijt J, de Graaf C, Stocks M, Kellam B, Briddon S, et al: Modulators of CXCR4 and CXCR7/ACKR3 function. Mol Pharmacol. 96:737–752. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Don-Salu-Hewage AS, Chan SY, McAndrews KM, Chetram MA, Dawson MR, Bethea DA and Hinton CV: Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells. PLoS One. 8:e571942013. View Article : Google Scholar : PubMed/NCBI |
|
Kamal A, Fain C, Park A, Wang P, Gonzalez-Velez E, Leffler DA and Hutfless SM: Angiotensin II receptor blockers and gastrointestinal adverse events of resembling sprue-like enteropathy: A systematic review. Gastroenterol Rep (Oxf). 7:162–167. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Bundalo M, Djordjevic A, Bursac B, Zivkovic M, Koricanac G and Stanković A: Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue. Appl Physiol Nutr Metab. 42:1254–1263. 2017. View Article : Google Scholar : PubMed/NCBI |
|
Hogan KA, Chini CCS and Chini EN: The multi-faceted ecto-enzyme CD38: Roles in immunomodulation, cancer, aging, and metabolic diseases. Front Immunol. 10:11872019. View Article : Google Scholar : PubMed/NCBI |
|
Orciani M, Trubiani O, Guarnieri S, Ferrero E and Di Primio R: CD38 is constitutively expressed in the nucleus of human hematopoietic cells. J Cell Biochem. 105:905–912. 2008. View Article : Google Scholar : PubMed/NCBI |
|
Sharma V and O'Halloran DM: Recent structural and functional insights into the family of sodium calcium exchangers. Genesis. 52:93–109. 2014. View Article : Google Scholar : PubMed/NCBI |
|
Ledeen RW and Wu G: Sodium-calcium exchangers in the nucleus: An unexpected locus and an unusual regulatory mechanism. Ann N Y Acad Sci. 1099:494–506. 2007. View Article : Google Scholar : PubMed/NCBI |
|
Philippova M, Joshi MB, Kyriakakis E, Pfaff D, Erne P and Resink TJ: A guide and guard: The many faces of T-cadherin. Cell Signal. 21:1035–1044. 2009. View Article : Google Scholar : PubMed/NCBI |
|
Andreeva AV, Kutuzov MA, Tkachuk VA and Voyno-Yasenetskaya TA: T-cadherin is located in the nucleus and centrosomes in endothelial cells. Am J Physiol Cell Physiol. 297:C1168–C1177. 2009. View Article : Google Scholar : PubMed/NCBI |
|
Bauer H, Zweimueller-Mayer J, Steinbacher P, Lametschwandtner A and Bauer HC: The dual role of zonula occludens ZO) proteins. J Biomed Biotechnol. 2010:4025932010. View Article : Google Scholar : PubMed/NCBI |
|
Traweger A, Lehner C, Farkas A, Krizbai IA, Tempfer H, Klement E, Guenther B, Bauer HC and Bauer H: Nuclear Zonula occludens-2 alters gene expression and junctional stability in epithelial and endothelial cells. Differentiation. 76:99–106. 2008. View Article : Google Scholar : PubMed/NCBI |
|
Bonacquisti EE and Nguyen J: Connexin 43 (Cx43) in cancer: Implications for therapeutic approaches via gap junctions. Cancer Lett. 442:439–444. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Dang X, Doble BW and Kardami E: The carboxy-tail of connexin-43 localizes to the nucleus and inhibits cell growth. Mol Cell Biochem. 242:35–38. 2003. View Article : Google Scholar : PubMed/NCBI |
|
Chen X, Kong X, Zhuang W, Teng B, Yu X, Hua S, Wang S, Liang F, Ma D, Zhang S, et al: Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells. Sci Rep. 6:212242016. View Article : Google Scholar : PubMed/NCBI |
|
Dzobo K, Thomford NE and Senthebane DA: Targeting the versatile Wnt/β-Catenin pathway in cancer biology and therapeutics: From concept to actionable strategy. OMICS. 23:517–538. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Kim W, Kim M and Jho EH: Wnt/β-catenin signalling: From plasma membrane to nucleus. Biochem J. 450:9–21. 2013. View Article : Google Scholar : PubMed/NCBI |
|
Johnson M, Sharma M, Jamieson C, Henderson JM, Mok MT, Bendall L and Henderson BR: Regulation of beta-catenin trafficking to the membrane in living cells. Cell Signal. 21:339–348. 2009. View Article : Google Scholar : PubMed/NCBI |
|
Neufeld KL: Nuclear APC. Adv Exp Biol. 656:13–29. 2009. View Article : Google Scholar : PubMed/NCBI |
|
Daniel JM: Dancing in and out of the nucleus: p120(ctn) and the transcription factor Kaiso. Biochim Biophys Acta. 1773:59–68. 2007. View Article : Google Scholar : PubMed/NCBI |
|
Wang YX, Wang DY, Guo YC and Guo J: Zyxin: A mechanotransductor to regulate gene expression. Eur Rev Med Pharmacol Sci. 23:413–425. 2019.PubMed/NCBI |
|
Nix DA, Fradelizi J, Bockholt S, Menichi B, Louvard D, Friederich E and Beckerle MC: Targeting of zyxin to sites of actin membrane interaction and to the nucleus. J Biol Chem. 276:34759–34767. 2001. View Article : Google Scholar : PubMed/NCBI |
|
Hohenester E: Laminin G-like domains: Dystroglycan-specific lectins. Curr Opin Struct Biol. 56:56–63. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Gracida-Jiménez V, Mondragón-González R, Vélez-Aguilera G, Vásquez-Limeta A, Laredo-Cisneros MS, Gómez-López JD, Vaca L, Gourlay SC, Jacobs LA, Winder SJ and Cisneros B: Publisher Correction: Retrograde trafficking of β-dystroglycan from the plasma membrane to the nucleus. Sci Rep. 8:177852018. View Article : Google Scholar : PubMed/NCBI |
|
Guo X, Elkashef SM, Loadman PM, Patterson LH and Falconer RA: Recent advances in the analysis of polysialic acid from complex biological systems. Carbohydr Polym. 224:1151452019. View Article : Google Scholar : PubMed/NCBI |
|
Westphal N, Loers G, Lutz D, Theis T, Kleene R and Schachner M: Generation and intracellular trafficking of a polysialic acid-carrying fragment of the neural cell adhesion molecule NCAM to the cell nucleus. Sci Rep. 7:86222017. View Article : Google Scholar : PubMed/NCBI |
|
Bianchi G and Cusi D: Association and linkage analysis of alpha-adducin polymorphism: Is the glass half full or half empty? Am J Hypertens. 13((6 Pt 1)): 739–743. 2000. View Article : Google Scholar : PubMed/NCBI |
|
Chen CL, Lin YP, Lai YC and Chen HC: α-Adducin translocates to the nucleus upon loss of cell-cell adhesions. Traffic. 12:1327–1340. 2011. View Article : Google Scholar : PubMed/NCBI |
|
Zhou J, Yi Q and Tang L: The roles of nuclear focal adhesion kinase (FAK) on cancer: A focused review. J Exp Clin Cancer Res. 38:2502019. View Article : Google Scholar : PubMed/NCBI |
|
Jones G and Stewart G: Nuclear import of N-terminal FAK by activation of the FcepsilonRI receptor in RBL-2H3 cells. Biochem Biophys Res Commun. 314:39–45. 2004. View Article : Google Scholar : PubMed/NCBI |
|
Tanos BE, Yeaman C and Rodriguez-Boulan E: An emerging role for IQGAP1 in tight junction control. Small GTPases. 9:375–383. 2018. View Article : Google Scholar : PubMed/NCBI |
|
Johnson M, Sharma M, Brocardo MG and Henderson BR: IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. Int J Biochem Cell Biol. 43:65–73. 2011. View Article : Google Scholar : PubMed/NCBI |
|
Yang X and Liu K: P-gp inhibition-based strategies for modulating pharmacokinetics of anticancer drugs: An update. Curr Drug Metab. 17:806–826. 2016. View Article : Google Scholar : PubMed/NCBI |
|
Tome ME, Herndon JM, Schaefer CP, Jacobs LM, Zhang Y, Jarvis CK and Davis TP: P-glycoprotein traffics from the nucleus to the plasma membrane in rat brain endothelium during inflammatory pain. J Cereb Blood Flow Metab. 36:1913–1928. 2016. View Article : Google Scholar : PubMed/NCBI |
|
Khot MI, Downey CL, Armstrong G, Svavarsdottir HS, Jarral F, Andrew H and Jayne DG: The role of ABCG2 in modulating responses to anti-cancer photodynamic therapy. Photodiagnosis Photodyn Ther. 29:1015792020. View Article : Google Scholar : PubMed/NCBI |
|
Liang SC, Yang CY, Tseng JY, Wang HL, Tung CY, Liu HW, Chen CY, Yeh YC, Chou TY, Yang MH, et al: ABCG2 localizes to the nucleus and modulates CDH1 expression in lung cancer cells. Neoplasia. 17:265–278. 2015. View Article : Google Scholar : PubMed/NCBI |
|
Crino PB: Mechanistic target of rapamycin (mTOR) signaling in status epilepticus. Epilepsy Behav. 101((Pt B)): 1065502019. View Article : Google Scholar : PubMed/NCBI |
|
Zhang X, Shu L, Hosoi H, Murti KG and Houghton PJ: Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. J Biol Chem. 277:28127–28134. 2002. View Article : Google Scholar : PubMed/NCBI |
|
Rusciano MR, Sommariva E, Douin-Echinard V, Ciccarelli M, Poggio P and Maione AS: CaMKII activity in the inflammatory response of cardiac diseases. Int J Mol Sci. 20:43742019. View Article : Google Scholar : PubMed/NCBI |
|
Ma H, Groth RD, Cohen SM, Emery JF, Li B, Hoedt E, Zhang G, Neubert TA and Tsien RW: γCaMKII shuttles Ca2+/CaM to the nucleus to trigger CREB phosphorylation and gene expression. Cell. 159:281–294. 2014. View Article : Google Scholar : PubMed/NCBI |
|
O'Brien JB, Wilkinson JC and Roman DL: Regulator of G protein signaling (RGS) proteins as drug targets: Progress and future potentials. J Biol Chem. 294:18571–18585. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Hepler JR: R7BP: A surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain. Sco STKE. 2005:pe382005.PubMed/NCBI |
|
Thomas MP, Erneux C and Potter BV: SHIP2: Structure, function and inhibition. Chembiochem. 18:233–247. 2017. View Article : Google Scholar : PubMed/NCBI |
|
Elong Edimo W, Vanderwinden JM and Erneux C: SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts. Adv Biol Regul. 53:28–37. 2013. View Article : Google Scholar : PubMed/NCBI |
|
Bill CA and Vines CM: Phospholipase C. Adv Exp Med Biol. 1131:215–242. 2020. View Article : Google Scholar : PubMed/NCBI |
|
Pan G, Cao X, Liu B, Li C, Li D, Zheng J, Lai C, Olkkonen VM, Zhong W and Yan D: OSBP-related protein 4L promotes phospholipase Cβ3 translocation from the nucleus to the plasma membrane in Jurkat T-cells. J Biol Chem. 293:17430–17441. 2018. View Article : Google Scholar : PubMed/NCBI |
|
Mérida I, Arranz-Nicolás J, Rodríguez-Rodríguez C and Ávila-Flores A: Diacylglycerol kinase control of protein kinase C. Biochem J. 476:1205–1219. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Divecha N, Treagus J, Vann L and D'santos C: Phospholipases in the nucleus. Semin Cell Dev Biol. 8:323–331. 1997. View Article : Google Scholar : PubMed/NCBI |
|
Cheng Y, Duan C and Zhang C: New perspective on SH2B1: An accelerator of cancer progression. Biomed Pharmacother. 121:1096512020. View Article : Google Scholar : PubMed/NCBI |
|
Maures TJ, Chen L and Carter-Su C: Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes. Mol Endocrinol. 23:1077–1091. 2009. View Article : Google Scholar : PubMed/NCBI |
|
Venken T, Schillinger AS, Fuglebakk E and Reuter N: Interactions stabilizing the C-terminal helix of human phospholipid scramblase 1 in lipid bilayers: A computational study. Biochim Biophys Acta Biomembr. 1859:1200–1210. 2017. View Article : Google Scholar : PubMed/NCBI |
|
Wiedmer T, Zhao J, Nanjundan M and Sims PJ: Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane. Biochemistry. 42:1227–1233. 2003. View Article : Google Scholar : PubMed/NCBI |
|
Xi S, Tie Y, Lu K, Zhang M, Yin X, Chen J, Xing G, Tian C, Zheng X, He F and Zhang L: N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its nucleus-plasma membrane shuttling. FEBS Lett. 584:1223–1230. 2010. View Article : Google Scholar : PubMed/NCBI |
|
Zhou F, Li F, Xie F, Zhang Z, Huang H and Zhang L: TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer. Sci China Life Sci. 57:1172–1176. 2014. View Article : Google Scholar : PubMed/NCBI |
|
Kédinger V, Alpy F, Baguet A, Polette M, Stoll I, Chenard MP, Tomasetto C and Rio MC: Tumor necrosis factor receptor-associated factor 4 is a dynamic tight junction-related shuttle protein involved in epithelium homeostasis. PLoS One. 3:e35182008. View Article : Google Scholar : PubMed/NCBI |
|
Zheng Y and Tyner AL: Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer. Eur J Clin Invest. 43:397–404. 2013. View Article : Google Scholar : PubMed/NCBI |
|
Ie Kim H and Lee ST: Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus. J Biochem. 146:133–139. 2009. View Article : Google Scholar : PubMed/NCBI |
|
Yau MK, Lim J, Liu L and Fairlie DP: Protease activated receptor 2 (PAR2) modulators: A patent review (2010–2015). Expert Opin Ther Pat. 26:471–483. 2016. View Article : Google Scholar : PubMed/NCBI |
|
Joyal JS, Nim S, Zhu T, Sitaras N, Rivera JC, Shao Z, Sapieha P, Hamel D, Sanchez M, Zaniolo K, et al: Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med. 20:1165–1173. 2014. View Article : Google Scholar : PubMed/NCBI |
|
Pekar O, Benjamin S, Weidberg H, Smaldone S, Ramirez F and Horowitz M: EHD2 shuttles to the nucleus and represses transcription. Biochem J. 444:383–394. 2012. View Article : Google Scholar : PubMed/NCBI |
|
Takahashi M, Tsukamoto Y, Kai T, Tokunaga A, Nakada C, Hijiya N, Uchida T, Daa T, Nomura T, Sato F, et al: Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma. Cancer Sci. 107:417–423. 2016. View Article : Google Scholar : PubMed/NCBI |
|
Olazabal-Herrero A, Sendino M, Arganda-Carreras I and Rodríguez JA: WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus. Eur J Cell Biol. 98:12–26. 2019. View Article : Google Scholar : PubMed/NCBI |
|
Ugrinova I, Petrova M, Chalabi-Dchar M and Bouvet P: Multifaceted nucleolin protein and its molecular partners in oncogenesis. Adv Protein Chem Struct Biol. 111:133–164. 2018. View Article : Google Scholar : PubMed/NCBI |
|
Hovanessian AG, Soundaramourty C, El Khoury D, Nondier I, Svab J and Krust B: Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization. PLoS One. 5:e157872010. View Article : Google Scholar : PubMed/NCBI |
|
Chen X, Kube DM, Cooper MJ and Davis PB: Cell surface nucleolin serves as receptor for DNA nanoparticles composed of pegylated polylysine and DNA. Mol Ther. 16:333–342. 2008. View Article : Google Scholar : PubMed/NCBI |
|
McQuown SC and Wood MA: HDAC3 and the molecular brake pad hypothesis. Neurobiol Learn Mem. 96:27–34. 2011. View Article : Google Scholar : PubMed/NCBI |
|
Longworth MS and Laimins LA: Histone deacetylase 3 localizes to the plasma membrane and is a substrate of Src. Oncogene. 25:4495–4500. 2006. View Article : Google Scholar : PubMed/NCBI |