Small‑molecule PKR‑like endoplasmic reticulum kinase inhibitors as a novel targeted therapy for Parkinson's disease
- Authors:
- Weronika Lusa
- Wioletta Rozpędek-Kamińska
- Natalia Siwecka
- Grzegorz Galita
- Ireneusz Majsterek
- Ewa Kucharska
-
Affiliations: Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 92-213 Lodz, Poland, Department of Geriatrics and Social Work, Jesuit University Ignatianum in Krakow, 31-501 Krakow, Poland - Published online on: March 30, 2023 https://doi.org/10.3892/mmr.2023.12989
- Article Number: 102
This article is mentioned in:
Abstract
2H‑tetrazolium‑5‑carboxanilide assay and apoptosis was assessed using a caspase‑3 assay. Moreover, cell cycle progression was evaluated using flow cytometry. The results indicated that LDN‑87357 treatment induced a significant decrease in ER stress markers gene expression in SH‑SY5Y cells exposed to ER stress. Furthermore, LDN‑87357 significantly increased viability, diminished apoptosis and restored the normal cell cycle distribution of SH‑SY5Y cells after ER stress induction. Therefore, the evaluation of small‑molecule PERK inhibitors, such as LDN‑87357, may lead to the development of novel therapeutic strategies against PD.
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