Open Access

Hesperetin treatment attenuates glycation of lens proteins and advanced‑glycation end products generation

  • Authors:
    • Yuri Doki
    • Yosuke Nakazawa
    • Naoki Morishita
    • Shin Endo
    • Noriaki Nagai
    • Naoki Yamamoto
    • Hiroomi Tamura
    • Megumi Funakoshi‑Tago
  • View Affiliations

  • Published online on: March 30, 2023     https://doi.org/10.3892/mmr.2023.12990
  • Article Number: 103
  • Copyright: © Doki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Advanced glycation end products (AGEs) in lens proteins increase with aging, thus inducing cataracts and/or presbyopia. Hesperetin (Hst), which is an abundant plant flavanone largely derived from citrus species, and its derivatives attenuate cataracts and presbyopia in vivo and in vitro; however, no reports have described its effects on AGE formation in lens proteins. The present study demonstrated that AGEs in lens proteins increase with age in mice. Additionally, it showed that Hst can prevent AGEs and N(ε)‑carboxymethyl‑lysine generation and modification of lens proteins using in vitro in human lens epithelial cell lines and ex vivo in mouse lens organ cultures. Furthermore, treatment with Hst prevented lens hardening and decreased chaperone activity in lens proteins. These results suggested that Hst and its derivatives are good candidates for the prevention of presbyopia and cataracts.
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May-2023
Volume 27 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Doki Y, Nakazawa Y, Morishita N, Endo S, Nagai N, Yamamoto N, Tamura H and Funakoshi‑Tago M: Hesperetin treatment attenuates glycation of lens proteins and advanced‑glycation end products generation. Mol Med Rep 27: 103, 2023.
APA
Doki, Y., Nakazawa, Y., Morishita, N., Endo, S., Nagai, N., Yamamoto, N. ... Funakoshi‑Tago, M. (2023). Hesperetin treatment attenuates glycation of lens proteins and advanced‑glycation end products generation. Molecular Medicine Reports, 27, 103. https://doi.org/10.3892/mmr.2023.12990
MLA
Doki, Y., Nakazawa, Y., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Tamura, H., Funakoshi‑Tago, M."Hesperetin treatment attenuates glycation of lens proteins and advanced‑glycation end products generation". Molecular Medicine Reports 27.5 (2023): 103.
Chicago
Doki, Y., Nakazawa, Y., Morishita, N., Endo, S., Nagai, N., Yamamoto, N., Tamura, H., Funakoshi‑Tago, M."Hesperetin treatment attenuates glycation of lens proteins and advanced‑glycation end products generation". Molecular Medicine Reports 27, no. 5 (2023): 103. https://doi.org/10.3892/mmr.2023.12990